Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Kenny Roose"'
Autor:
Delphine Diana Acar, Wojciech Witkowski, Magdalena Wejda, Ruifang Wei, Tim Desmet, Bert Schepens, Sieglinde De Cae, Koen Sedeyn, Hannah Eeckhaut, Daria Fijalkowska, Kenny Roose, Sandrine Vanmarcke, Anne Poupon, Dirk Jochmans, Xin Zhang, Rana Abdelnabi, Caroline S. Foo, Birgit Weynand, Dirk Reiter, Nico Callewaert, Han Remaut, Johan Neyts, Xavier Saelens, Sarah Gerlo, Linos Vandekerckhove
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104960- (2024)
Summary: Background: SARS-CoV-2-neutralizing antibodies (nABs) showed great promise in the early phases of the COVID-19 pandemic. The emergence of resistant strains, however, quickly rendered the majority of clinically approved nABs ineffective. This
Externí odkaz:
https://doaj.org/article/d61b439c0eca42cfae0b6e3405d320a1
Autor:
Emiel Michiels, Kenny Roose, Rodrigo Gallardo, Ladan Khodaparast, Laleh Khodaparast, Rob van der Kant, Maxime Siemons, Bert Houben, Meine Ramakers, Hannah Wilkinson, Patricia Guerreiro, Nikolaos Louros, Suzanne J. F. Kaptein, Lorena Itatí Ibañez, Anouk Smet, Pieter Baatsen, Shu Liu, Ina Vorberg, Guy Bormans, Johan Neyts, Xavier Saelens, Frederic Rousseau, Joost Schymkowitz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/c25558682e604351be0ae8e8c8234335
Autor:
Lien Van Hoecke, Kenny Roose, Marlies Ballegeer, Zifu Zhong, Niek N. Sanders, Stefaan De Koker, Xavier Saelens, Sandra Van Lint
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 22, Iss , Pp 373-381 (2020)
mRNA-lipoplex vaccines are currently being explored in phase II clinical trials for the treatment of patients with advanced solid tumors. Mechanistically, these mRNA-lipoplex vaccines are characterized by the induction of type I interferon (IFN) cent
Externí odkaz:
https://doaj.org/article/0d322f9a8baa46c59fd0f61a81777a2c
Autor:
Robbert Boudewijns, Hendrik Jan Thibaut, Suzanne J. F. Kaptein, Rong Li, Valentijn Vergote, Laura Seldeslachts, Johan Van Weyenbergh, Carolien De Keyzer, Lindsey Bervoets, Sapna Sharma, Laurens Liesenborghs, Ji Ma, Sander Jansen, Dominique Van Looveren, Thomas Vercruysse, Xinyu Wang, Dirk Jochmans, Erik Martens, Kenny Roose, Dorien De Vlieger, Bert Schepens, Tina Van Buyten, Sofie Jacobs, Yanan Liu, Joan Martí-Carreras, Bert Vanmechelen, Tony Wawina-Bokalanga, Leen Delang, Joana Rocha-Pereira, Lotte Coelmont, Winston Chiu, Pieter Leyssen, Elisabeth Heylen, Dominique Schols, Lanjiao Wang, Lila Close, Jelle Matthijnssens, Marc Van Ranst, Veerle Compernolle, Georg Schramm, Koen Van Laere, Xavier Saelens, Nico Callewaert, Ghislain Opdenakker, Piet Maes, Birgit Weynand, Christopher Cawthorne, Greetje Vande Velde, Zhongde Wang, Johan Neyts, Kai Dallmeier
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
SARS-CoV-2 infection can result in severe lung inflammation and pathology, but host response remains incompletely understood. Here the authors show in Syrian hamsters that STAT2 signaling restricts systemic virus dissemination but also drives severe
Externí odkaz:
https://doaj.org/article/4bd55434a94243038b030da67ad476bb
Autor:
Emiel Michiels, Kenny Roose, Rodrigo Gallardo, Ladan Khodaparast, Laleh Khodaparast, Rob van der Kant, Maxime Siemons, Bert Houben, Meine Ramakers, Hannah Wilkinson, Patricia Guerreiro, Nikolaos Louros, Suzanne J. F. Kaptein, Lorena Itatí Ibañez, Anouk Smet, Pieter Baatsen, Shu Liu, Ina Vorberg, Guy Bormans, Johan Neyts, Xavier Saelens, Frederic Rousseau, Joost Schymkowitz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Abstract Human amyloids have been shown to interact with viruses and interfere with viral replication. Based on this observation, we employed a synthetic biology approach in which we engineered virus-specific amyloids against influenza A and Zika pro
Externí odkaz:
https://doaj.org/article/ffcec336575043bba6212cbf4b6b3b72
Autor:
Lien Van Hoecke, Rein Verbeke, Dorien De Vlieger, Heleen Dewitte, Kenny Roose, Sharon Van Nevel, Olga Krysko, Claus Bachert, Bert Schepens, Ine Lentacker, Xavier Saelens
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 20, Iss , Pp 777-787 (2020)
To date, mRNA-based biologics have mainly been developed for prophylactic and therapeutic vaccination to combat infectious diseases or cancer. In the past years, optimization of the characteristics of in vitro transcribed mRNA has led to significant
Externí odkaz:
https://doaj.org/article/decaab1f652f4c3390dafc7e91faf84c
Autor:
Silvie Van den Hoecke, Marlies Ballegeer, Bram Vrancken, Lei Deng, Emma R. Job, Kenny Roose, Bert Schepens, Lien Van Hoecke, Philippe Lemey, Xavier Saelens
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT The ectodomain of matrix protein 2 (M2e) of influenza A viruses is a universal influenza A vaccine candidate. Here, we report potential evasion strategies of influenza A viruses under in vivo passive anti-M2e IgG immune selection pressure in
Externí odkaz:
https://doaj.org/article/d51386aa0cb244889e4bdf58c40d32b6
Autor:
Lien Van Hoecke, Kenny Roose
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-14 (2019)
Abstract In 1975, Milstein and Köhler revolutionized the medical world with the development of the hybridoma technique to produce monoclonal antibodies. Since then, monoclonal antibodies have entered almost every branch of biomedical research. Antib
Externí odkaz:
https://doaj.org/article/c8e578a5b7b248fbb7b328378c2d5418
Autor:
Lien Van Hoecke, Sandra Van Lint, Kenny Roose, Alexander Van Parys, Peter Vandenabeele, Johan Grooten, Jan Tavernier, Stefaan De Koker, Xavier Saelens
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Necroptosis has immunogenic cell death properties. Here, the authors show that the intra-tumor delivery of mRNA that codes for the necroptosis effector MLKL triggers neo-epitope-specific anti-tumor T cell responses and inhibits primary tumor growth a
Externí odkaz:
https://doaj.org/article/8238d6be45a64c8a92375d54457b3e83
Autor:
Jonathan Maelfait, Kenny Roose, Lars Vereecke, Conor Mc Guire, Mozes Sze, Martijn J Schuijs, Monique Willart, Lorena Itati Ibañez, Hamida Hammad, Bart N Lambrecht, Rudi Beyaert, Xavier Saelens, Geert van Loo
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005410 (2016)
A20 negatively regulates multiple inflammatory signalling pathways. We here addressed the role of A20 in club cells (also known as Clara cells) of the bronchial epithelium in their response to influenza A virus infection. Club cells provide a niche f
Externí odkaz:
https://doaj.org/article/b353388aaad34cc2808b975704730a7d