Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Kenny Bravo Rodriguez"'
Autor:
Nathalie Beaufort, Linda Ingendahl, Melisa Merdanovic, Andree Schmidt, David Podlesainski, Tim Richter, Thorben Neumann, Michael Kuszner, Ingrid R. Vetter, Patricia Stege, Steven G. Burston, Anto Filipovic, Yasser B. Ruiz-Blanco, Kenny Bravo-Rodriguez, Joel Mieres-Perez, Christine Beuck, Stephan Uebel, Monika Zobawa, Jasmin Schillinger, Rainer Malik, Katalin Todorov-Völgyi, Juliana Rey, Annabell Roberti, Birte Hagemeier, Benedikt Wefers, Stephan A. Müller, Wolfgang Wurst, Elsa Sanchez-Garcia, Alexander Zimmermann, Xiao-Yu Hu, Tim Clausen, Robert Huber, Stefan F. Lichtenthaler, Carsten Schmuck, Michael Giese, Markus Kaiser, Michael Ehrmann, Martin Dichgans
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Loss-of-function mutations in the homotrimeric serine protease HTRA1 cause cerebral vasculopathy. Here, we establish independent approaches to achieve the functional correction of trimer assembly defects. Focusing on the prototypical R274Q m
Externí odkaz:
https://doaj.org/article/ecefd6f18eff4edf90c7e557870791d5
Autor:
Andreas Sprengel, Pascal Lill, Pierre Stegemann, Kenny Bravo-Rodriguez, Elisa-C. Schöneweiß, Melisa Merdanovic, Daniel Gudnason, Mikayel Aznauryan, Lisa Gamrad, Stephan Barcikowski, Elsa Sanchez-Garcia, Victoria Birkedal, Christos Gatsogiannis, Michael Ehrmann, Barbara Saccà
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Current strategies for protein encapsulation in DNA vessels for controlled enzymatic catalysis or therapeutic delivery rely on formation of covalent complexes. Here, the authors design a system that mimics natural reversible non-covalent host–guest
Externí odkaz:
https://doaj.org/article/5226d94ebae64287be29caae8f6fe6be
Autor:
Anup Arumughan, Yvette Roske, Carolin Barth, Laura Lleras Forero, Kenny Bravo-Rodriguez, Alexandra Redel, Simona Kostova, Erik McShane, Robert Opitz, Katja Faelber, Kirstin Rau, Thorsten Mielke, Oliver Daumke, Matthias Selbach, Elsa Sanchez-Garcia, Oliver Rocks, Daniela Panáková, Udo Heinemann, Erich E. Wanker
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The AAA+ ATPase p97 is an essential hexameric protein with multiple protein interaction partners and cellular functions. Here, the authors use interaction mapping to examine partner proteins of this large complex, and assess the effects of these prot
Externí odkaz:
https://doaj.org/article/c05c3467f02d4df0b4320632445b06fa
Autor:
Stephan Klopries, Kenny Bravo-Rodriguez, Kyra R.M. Koopmans, Uschi Sundermann, Samir Yahiaoui, Julia Arens, Susanna Kushnir, Elsa Sanchez-Garcia, Frank Schulz
Publikováno v:
Data in Brief, Vol 5, Iss C, Pp 528-536 (2015)
Enzyme-directed mutasynthesis is an emerging strategy for the targeted derivatization of natural products. Here, data on the synthesis of malonic acid derivatives for feeding studies in Saccharopolyspora erythraea , the mutagenesis of DEBS and bioana
Externí odkaz:
https://doaj.org/article/50f2172f437340e9a54167062ede0435
Autor:
Jasmin Schillinger, Michelle Koci, Kenny Bravo-Rodriguez, Geronimo Heilmann, Farnusch Kaschani, Markus Kaiser, Christine Beuck, Hartmut Luecke, Robert Huber, Doris Hellerschmied, Steven G. Burston, Michael Ehrmann
Proteolysis is a key catalytic event in protein and thus cellular homeostasis. Despite the importance and wide implications of proteolytic processing and degradation, methods describing the degradation of folded proteins at high temporal and spatial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e1a8f5a84e6a4dd124d2c8969f22e16
https://doi.org/10.1101/2022.03.24.485615
https://doi.org/10.1101/2022.03.24.485615
Autor:
Richard Kosinski, Joel Mieres Perez, Elisa-C. Schöneweiß, Yasser B. Ruiz-Blanco, Irene Ponzo, Kenny Bravo-Rodriguez, Michael Erkelenz, Sebastian Schlücker, Guido Uhlenbrock, Elsa Sanchez-Garcia, Barbara Saccà
Publikováno v:
Science Advances
Description
DNA nanostructures invert the catalytic response of thrombin to substrates of opposite net charge.
DNA-scaffolded enzymes typically show altered kinetic properties; however, the mechanism behind this phenomenon is still poorly u
DNA nanostructures invert the catalytic response of thrombin to substrates of opposite net charge.
DNA-scaffolded enzymes typically show altered kinetic properties; however, the mechanism behind this phenomenon is still poorly u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ee34d06ead4acff2dfcd9e6d9add5a
https://doi.org/10.1126/sciadv.abk0425
https://doi.org/10.1126/sciadv.abk0425
Autor:
Juliana Rey, Maike Breiden, Vanda Lux, Anika Bluemke, Maike Steindel, Kamilla Ripkens, Bastian Möllers, Kenny Bravo Rodriguez, Prisca Boisguerin, Rudolf Volkmer, Joel Mieres-Perez, Tim Clausen, Elsa Sanchez-Garcia, Michael Ehrmann
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (14), pp.e2113520119. ⟨10.1073/pnas.2113520119⟩
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (14), pp.e2113520119. ⟨10.1073/pnas.2113520119⟩
Significance Classic serine proteases are synthesized as inactive precursors that are proteolytically processed, resulting in irreversible activation. We report an alternative and reversible mechanism of activation that is executed by an inactive pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bffd9bbaeb049d992fcf1c102e5723
https://hal.science/hal-03625904
https://hal.science/hal-03625904
Autor:
Edina Lump, Laura M Castellano, Christoph Meier, Janine Seeliger, Nelli Erwin, Benjamin Sperlich, Christina M Stürzel, Shariq Usmani, Rebecca M Hammond, Jens von Einem, Gisa Gerold, Florian Kreppel, Kenny Bravo-Rodriguez, Thomas Pietschmann, Veronica M Holmes, David Palesch, Onofrio Zirafi, Drew Weissman, Andrea Sowislok, Burkhard Wettig, Christian Heid, Frank Kirchhoff, Tanja Weil, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan, Elsa Sanchez-Garcia, Roland Winter, James Shorter, Jan Münch
Publikováno v:
eLife, Vol 4 (2015)
Semen is the main vector for HIV transmission and contains amyloid fibrils that enhance viral infection. Available microbicides that target viral components have proven largely ineffective in preventing sexual virus transmission. In this study, we es
Externí odkaz:
https://doaj.org/article/0c9550c7aa694a08a411342bf36bd1d9
Autor:
Florian Kreppel, Janis A. Müller, Jens von Einem, Tatjana Weil, Elsa Sanchez-Garcia, Clarissa Read, Sina Lippold, Gal Bitan, Christina M. Stürzel, Thomas Schrader, Michael Ehrmann, Marco Hebel, Frank-Gerrit Klärner, Roland Winter, Paul Bates, Mridula Dwivedi, Andrea Sowislok, Tanja Weil, Annika Röcker, Jan Münch, Rüdiger Groß, Konstantin M. J. Sparrer, Lukas Wettstein, Yasser B. Ruiz-Blanco, Paul Walther, Kenny Bravo-Rodriguez, My Hue Le, James Shorter, Nelli Erwin, Mirja Harms, Stephen M. Bart, Christian Heid
Publikováno v:
Journal of the American Chemical Society, vol 142, iss 40
Journal of the American Chemical Society
Journal of the American Chemical Society
Broad-spectrum antivirals are powerful weapons against dangerous viruses where no specific therapy exists, as in the case of the ongoing SARS-CoV-2 pandemic. We discovered that a lysine- and arginine-specific supramolecular ligand (CLR01) destroys en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946cf9bab288e137126d44b6bb9cf2e0
https://escholarship.org/uc/item/3049q3fv
https://escholarship.org/uc/item/3049q3fv
Autor:
Christian Heid, Elsa Sanchez-Garcia, Christian Ottmann, Andrea Sowislok, David Bier, Jeroen Briels, Sumit Mittal, Kenny Bravo-Rodriguez, Burkhard Wettig, Thomas Schrader, Luc Brunsveld, Maria Bartel, Xavier Guillory
Publikováno v:
Journal of the American Chemical Society, 139(45), 16256-16263. American Chemical Society
Journal of the American Chemical Society
Journal of the American Chemical Society
Protein regions that are involved in protein-protein interactions (PPIs) very often display a high degree of intrinsic disorder, which is reduced during the recognition process. A prime example is binding of the rigid 14-3-3 adapter proteins to their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d165aca90e8713bcfc687052f0628b4
https://doi.org/10.1021/jacs.7b07939
https://doi.org/10.1021/jacs.7b07939