Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Kenning M. Anderson"'
Publikováno v:
Medical Hypotheses. 67:1375-1380
Antisense oligonucleotides (oligos) directed against transforming growth factor-alpha (TGF-alpha) and its binding site, the epidermal growth factor receptor (EGFR), have demonstrated in vitro and in vivo efficacy against both the PC-3 and LNCaP prost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37382127aaaf21786640df12bed25c13
https://doi.org/10.1016/j.mehy.2006.05.055
https://doi.org/10.1016/j.mehy.2006.05.055
Autor:
S. Jadko, D. Ou, Kenning M. Anderson, Jules E. Harris, P.K. Dudeja, Philip Bonomi, W.A. Alrefai, Y. Hu
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). 66:443-452
MK 886, an arachidonic acid-related analog which inhibits the enzyme, 5-lipoxygenase by an indirect mechanism involving the 5-lipoxygenase activating protein, rapidly increased U937 cytosol Ca 2+ , much of which localized around the cell nuclei. Five
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1d1ab3a727b3210c12d210bb90dcf9
https://doi.org/10.1054/plef.2001.0372
https://doi.org/10.1054/plef.2001.0372
Publikováno v:
Leukemia Research. 23:51-56
Whether 5- (and the 12- or 15-) lipoxygenases participate in normal or malignantly transformed hematopoietic cell proliferation and differentiation, or contribute to programmed or necrotic cell death has been difficult to decide. Recent evidence conc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935e85d08873ee15e7d06d1d228f8436
https://doi.org/10.1016/s0145-2126(98)00130-1
https://doi.org/10.1016/s0145-2126(98)00130-1
Publikováno v:
Medical Hypotheses. 52:53-57
Free radical spin traps exhibit properties consistent with a role in the prevention or amelioration of diseases mediated by the formation of free radical species in excess of optimum constitutive requirements. At first view, it may be surprising that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dca11d626b4b216af64441d47c5bbc2
https://doi.org/10.1054/mehy.1997.0627
https://doi.org/10.1054/mehy.1997.0627
Autor:
D. Ou, J. Meng, T. Seed, W.A. Alrefai, James L. Mulshine, Jules E. Harris, Kenning M. Anderson, Michele D. Vos
Publikováno v:
The Prostate. 37:161-173
BACKGROUND Products of the arachidonic acid-metabolizing enzyme, 5-lipoxygenase, stimulate the growth of several cell types. Selective inhibitors of the enzyme, including SC41661A and MK886, reduce PC-3 prostate cell proliferation. With continued cul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fc3ba793005cba807a879c0e5a7d022
https://doi.org/10.1002/(sici)1097-0045(19981101)37:3<161::aid-pros5>3.0.co
https://doi.org/10.1002/(sici)1097-0045(19981101)37:3<161::aid-pros5>3.0.co
Autor:
Kenning M. Anderson, Thomas M. Seed, D. Sawlani, D. Ou, Jules E. Harris, J. Meng, T. Buyn, Philip Bonomi, Pradeep K. Dudeja
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids. 56:69-77
Micromolar MK886, a selective inhibitor of 5-lipoxygenase at nanomolar concentration, induces physiologic cell death in U937 and chronic myelogenous leukemia blast cells. When U937 cells were challenged with 10 microM MK886, an acute, biphasic and su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599df9084a459d34509fe3a7f11dee10
https://doi.org/10.1016/s0952-3278(97)90527-5
https://doi.org/10.1016/s0952-3278(97)90527-5
Publikováno v:
Medical Hypotheses. 47:31-34
Presently, identified signal transduction pathways do not alter normal stem-cell survival. With prostate cancer as a model, the argument is advanced that an inability to eradicate normal androgen-dependent prostate stem-cells precludes successful tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73473f98a4ae1a887afc6cc48a1c4fa1
https://doi.org/10.1016/s0306-9877(96)90039-0
https://doi.org/10.1016/s0306-9877(96)90039-0
Publikováno v:
Leukemia Research. 19:789-801
Inhibitors of the arachidonic acid metabolizing enzyme, 5-lipoxygenase, reduce the rate of proliferation of chronic myelogenous leukemia blast cells. The inhibitory agents studied were ETYA, A63162 and SC41661A. These reagents induced differentiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7281ce305b872c537484d02a4b9136
https://doi.org/10.1016/0145-2126(95)00043-7
https://doi.org/10.1016/0145-2126(95)00043-7
Publikováno v:
Medical Hypotheses. 43:207-213
Recent information about apoptosis or programmed cell death, the anti-apoptotic gene, BCL2, its interaction with reactive oxygen species and the role of these agents in senescence and apoptosis, suggests a discussion of their relationships could be o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2319a4ecb4bb67148e40b71bf4b4f67
https://doi.org/10.1016/0306-9877(94)90067-1
https://doi.org/10.1016/0306-9877(94)90067-1
Autor:
Kenning M. Anderson, Jules E. Harris
Publikováno v:
Medical Hypotheses. 59:76-78
Much like mathematics, the biological and medical sciences seem unreasonably successful, considering many potential obstacles to this outcome. A recent suggestion that data should be viewed as `quantized', that each `elementary system' contains a sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9af5f41fe58aa2bb63bd78714222660
https://doi.org/10.1016/s0306-9877(02)00112-3
https://doi.org/10.1016/s0306-9877(02)00112-3