Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kennie R. Shepherd"'
Autor:
Kennie R. Shepherd, Shelley Cobb
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1733d44e05099d6a750f941464c77738
https://doi.org/10.1096/fasebj.2018.32.1_supplement.553.3
https://doi.org/10.1096/fasebj.2018.32.1_supplement.553.3
Autor:
Kennie R. Shepherd, Jae-Kyung Lee, Jianjun Chang, Chenere P. Ramsey, Isadora Porter, Malú G. Tansey, Jaegwon Chung, Danielle Oliver, George T. Kannarkat
Publikováno v:
Neurobiology of Aging. 36:1982-1993
Inflammation in the aging brain increases risk for neurodegenerative disease. In humans, the Regulator of G-protein Signaling (RGS) 10 locus has been associated with age-related maculopathy. Chronic peripheral administration of lipopolysaccharide in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5054a703aae1cc7806e09b26dcd22047
https://doi.org/10.1016/j.neurobiolaging.2015.02.006
https://doi.org/10.1016/j.neurobiolaging.2015.02.006
Autor:
Roberto Pattarini, Chunxu Qu, Yun Jiao, James I. Morgan, Kennie R. Shepherd, Richard J. Smeyne, Yongqi Rong
Publikováno v:
Neuroscience. 214:84-105
Parkinson’s disease (PD) is a progressive neurodegenerative disorder whose etiology is thought to have environmental (toxin) and genetic contributions. The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine (MPTP) induces pathological featur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63b7f2a3839b9d9d6b0a31bffbabda8
https://doi.org/10.1016/j.neuroscience.2012.03.047
https://doi.org/10.1016/j.neuroscience.2012.03.047
Autor:
Ge Xiao, Bruno Blanchi, Manuel Yepes, Yi E. Sun, Sung-Wuk Jang, W. David Wilson, Kennie R. Shepherd, Gary W. Miller, Yang Liu, Xia Liu, Keqiang Ye
Publikováno v:
Proceedings of the National Academy of Sciences. 107:2687-2692
Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis. However, BDNF has a poor pharmacokinetic profile that l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ade047dc627723498401870cc28e641
https://doi.org/10.1073/pnas.0913572107
https://doi.org/10.1073/pnas.0913572107
Autor:
Robert G. Webster, K. M. Sturm-Ramirez, David A. Boltz, Richard J. Smeyne, Yun Jiao, Kennie R. Shepherd, Haeman Jang
Publikováno v:
Proceedings of the National Academy of Sciences. 106:14063-14068
One of the greatest influenza pandemic threats at this time is posed by the highly pathogenic H5N1 avian influenza viruses. To date, 61% of the 433 known human cases of H5N1 infection have proved fatal. Animals infected by H5N1 viruses have demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a0c5f064713d45b96e61285d97fa76
https://doi.org/10.1073/pnas.0900096106
https://doi.org/10.1073/pnas.0900096106
Autor:
Justin D. Boyd, Ciaran J. Faherty, Richard J. Smeyne, Kennie R. Shepherd, Sally Slack, Yun Jiao, Haeman Jang
Publikováno v:
Brain Research. 1175:107-116
Parkinson's disease (PD) is a neurodegenerative disease whose hallmark pathological features include a selective loss of dopaminergic neurons in the midbrain. Recent studies have described the activation of a stress-induced signal cascade, c-Jun N-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9578f6cd821bb5130ed5c0c01eab9be
https://doi.org/10.1016/j.brainres.2007.07.067
https://doi.org/10.1016/j.brainres.2007.07.067
Autor:
Thomas S. Guillot, Kristen A. Stout, Kennie R. Shepherd, Tonya N. Taylor, Gary W. Miller, Minzheng Wang, Shawn P. Alter, Kelly M. Lohr
We previously demonstrated that mice with reduced expression of the vesicular monoamine transporter 2 (VMAT2 LO) undergo age-related degeneration of the catecholamine-producing neurons of the substantia nigra pars compacta and locus ceruleus and exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb91343389c27e50dd29519a06105ba
https://europepmc.org/articles/PMC4793730/
https://europepmc.org/articles/PMC4793730/
Publikováno v:
Glia. 52:144-152
Free radical damage has been shown to play a significant role in the pathogenesis of a number of neurodegenerative diseases including Parkinson's disease. One model of experimental parkinsonism is the loss of substantia nigra cells following administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba828fca2338286608ec9be3327459d
https://doi.org/10.1002/glia.20233
https://doi.org/10.1002/glia.20233
Autor:
Nazarius S. Lamango, Selina Darling-Reed, Zakia R. Williams, Clivel G. Charlton, Kennie R Shepherd, Eun Sook Lee, Wan-Qian Zhao, Jayne S. Reuben, Karam F.A. Soliman
Publikováno v:
Journal of Neuroscience Research. 69:519-529
Our previous studies showed that S-adenosyl-methionine (SAM) induced Parkinson's disease-like changes in rat. It caused death to dopamine neurons in the substantia nigra, which appeared shrunken and fragmented, indicative of apoptosis-like changes (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f36b60a830fe2faa796944d6553e59
https://doi.org/10.1002/jnr.10314
https://doi.org/10.1002/jnr.10314
Autor:
Kennie R. Shepherd, Hua She, Yoland Smith, Zixu Mao, Qian Yang, Gary W. Miller, Claudia M. Testa
Publikováno v:
The Journal of clinical investigation. 121(3)
The transcription factors in the myocyte enhancer factor 2 (MEF2) family play important roles in cell survival by regulating nuclear gene expression. Here, we report that MEF2D is present in rodent neuronal mitochondria, where it can regulate the exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21ab87b9c3fe57240287881268c4046
https://pubmed.ncbi.nlm.nih.gov/21393861
https://pubmed.ncbi.nlm.nih.gov/21393861