Výsledky vyhledávání - "Kennidy K. Takehara"

Transcriptional programming of CD4 + T RM differentiation in viral infection balances effector- and memory-associated gene expression

Autor: Quynh P. Nguyen, Kennidy K. Takehara, Tianda Z. Deng, Shannon O’Shea, Maximilian Heeg, Kyla D. Omilusik, J. Justin Milner, Sara Quon, Matthew E. Pipkin, Jinyong Choi, Shane Crotty, Ananda W. Goldrath

Publikováno v: Science Immunology. 8

After resolution of infection, T cells differentiate into long-lived memory cells that recirculate through secondary lymphoid organs or establish residence in tissues. In contrast to CD8 + tissue-resident memory T cells (T RM ), the developmental ori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8942a3bd04073df75435c1a7b19599bd
https://doi.org/10.1126/sciimmunol.abq7486

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Id3 expression identifies CD4 + memory Th1 cells

Autor: Laura A. Shaw, Tianda Z. Deng, Kyla D. Omilusik, Kennidy K. Takehara, Quynh P. Nguyen, Ananda W. Goldrath

Publikováno v: Proceedings of the National Academy of Sciences. 119

Memory CD4 + T cells play a pivotal role in mediating long-term protective immunity, positioning them as an important target in vaccine development. However, multiple functionally distinct helper CD4 + T-cell subsets can arise in response to a single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2ebf0f94fb17551568f109cf42575b7
https://doi.org/10.1073/pnas.2204254119

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Corrigendum to: SARS-CoV-2 Serologic Assays in Control and Unknown Populations Demonstrate the Necessity of Virus Neutralization Testing

Autor: Tien-Ying Hsiang, Marion Pepper, Kennidy K Takehara, Michael Gale, Zhaoqi Li, Jennifer A Rathe, Caleb Stokes, Julie Eggenberger, Jason Netland, Megan Knoll, Emily A. Hemann

Publikováno v: The Journal of Infectious Diseases

To determine how serologic antibody testing outcome links with virus neutralization of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we evaluated individuals for SARS-CoV-2 antibody level and viral neutralization.We compared serum Ig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f429e3cc037b8d19b706ab3e91f8138e
http://europepmc.org/articles/PMC8344695

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Multimeric antibodies from antigen-specific human IgM+ memory B cells restrict Plasmodium parasites

Autor: Christopher D. Thouvenel, Silvia Portugal, Eric M. Lynch, Mary F. Fontana, Marie Pancera, Suruchi Singh, Jason Netland, Kennidy K Takehara, Marion Pepper, Neil P. King, Peter D. Crompton, Gladys J. Keitany, Yu Chen, Carole A. Long, Akshay T. Krishnamurty, Kazutoyo Miura, David J. Rawlings, Marcos C. Miranda, Justin M. Kollman

Publikováno v: The Journal of Experimental Medicine

Thouvenel et al. isolate BCR sequences from Plasmodium-specific IgM+ human memory B cells, expressing them as both IgM and IgG molecules. Multimerization confers superior antigen binding and parasite restriction, highlighting an important role for me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05081f2f23d9d75c33be1816f0e6e347
https://doi.org/10.1084/jem.20200942

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SARS-CoV-2 Serologic Assays in Control and Unknown Populations Demonstrate the Necessity of Virus Neutralization Testing

Autor: Tien-Ying Hsiang, Emily A. Hemann, Julie Eggenberger, Caleb Stokes, Kennidy K Takehara, Jason Netland, Jennifer A Rathe, Michael Gale, Marion Pepper, Megan Knoll, Zhaoqi Li

Publikováno v: The Journal of Infectious Diseases

BackgroundTo determine how serologic antibody testing outcome links with virus neutralization of SARS-CoV-2 to ascertain immune protection status, we evaluated a unique set of individuals for SARS-CoV-2 antibody detection and viral neutralization.Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4420ebe29db09e4e09657b460b34d19d

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Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19

Publikováno v: Research Square
article-version (status) pre
article-version (number) 1
Cell

The SARS-CoV-2 virus is causing a global pandemic and cases continue to rise. Most infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that could c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f96f0c73740575efc8f305b85b0ec9
https://pubmed.ncbi.nlm.nih.gov/32818218

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Functional SARS-CoV-2-specific immune memory persists after mild COVID-19

Publikováno v: medRxiv

SummaryThe recently emerged SARS-CoV-2 virus is currently causing a global pandemic and cases continue to rise. The majority of infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85035c382474ae4765e0ba21e72655d

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The Development of Optimally Responsive Plasmodium-specific CD73+CD80+ IgM+ Memory B cells Requires Intrinsic BCL6 expression but not CD4+ Tfh cells

Autor: Gretchen Harms Pritchard, Kennidy K Takehara, Akshay T. Krishnamurty, Marion Pepper, Jason Netland, Arroyo En

SummaryHumoral immunity depends upon the development of long-lived, antibody-secreting plasma cells and rapidly responsive memory B cells (MBCs). The differentiation of high affinity, class-switched MBCs after immunization is critically dependent upo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f47a1d265a8683956f26ce39fd3041

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