Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kenneth Y. Zhu"'
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-12 (2019)
Abstract Background Neuroblastoma (NB) is the most common extracranial solid tumor found in children. The frequent gain/loss of many chromosome bands in tumor cells and absence of mutations found at diagnosis suggests that NB is a copy number-driven
Externí odkaz:
https://doaj.org/article/2c3cb04dba314d4b8a92b82fe79b335a
Publikováno v:
JCI Insight, Vol 6, Iss 11 (2021)
β3-Adrenergic receptors (β3-ARs) are the predominant regulators of rodent brown adipose tissue (BAT) thermogenesis. However, in humans, the physiological relevance of BAT and β3-AR remains controversial. Herein, using primary human adipocytes from
Externí odkaz:
https://doaj.org/article/76331fef2122485d889d38be91fd6594
Autor:
Frederick S. Varn, Evelien Schaafsma, Yanding Zhao, Chao Cheng, Kenneth Y. Zhu, Huan Yang, Yue Wang
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
Developing prognostic biomarkers for specific cancer types that accurately predict patient survival is increasingly important in clinical research and practice. Despite the enormous potential of prognostic signatures, proposed models have found limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab1350cb7cb914a7552b14fc7c847ac
https://doi.org/10.1038/s41374-020-0413-8
https://doi.org/10.1038/s41374-020-0413-8
Autor:
Laura A. Fletcher, Hannah J. Lea, Thomas M. Cassimatis, Kong Y. Chen, Kenneth Y. Zhu, Joyce D. Linderman, Robert J. Brychta, Alana E O'Mara, Aaron M. Cypess, Nikita Sanjay Israni, Zahraa Abdul Sater, James W. Johnson, Cheryl Cero
Publikováno v:
Journal of Biological Chemistry. 295:1926-1942
The current obesity pandemic results from a physiological imbalance in which energy intake chronically exceeds energy expenditure (EE), and prevention and treatment strategies remain generally ineffective. Approaches designed to increase EE have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ce7e977b40b8f34f50371959265053
https://doi.org/10.1074/jbc.rev119.007363
https://doi.org/10.1074/jbc.rev119.007363
Publikováno v:
Diabetes. 69
Recent clinical trials show that chronic activation of the β3-adrenergic receptor (AR) by mirabegron leads to numerous beneficial physiological responses, including increased energy expenditure, insulin sensitivity, and improved lipoprotein profile.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2f59195340f519aff5a3f18e21a7ee6
https://doi.org/10.2337/db20-208-lb
https://doi.org/10.2337/db20-208-lb
2020-P: ß3-Adrenergic Receptors Regulate Lipolysis and Thermogenesis in Human Brown/Beige Adipocytes
Publikováno v:
Diabetes. 69
Activation of rodent brown adipose tissue (BAT) via pharmacological stimulation of β3-adrenergic receptors (β3-AR) leads to metabolic benefit, however in humans, the physiological relevance of BAT and β3-AR remain controversial. To investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7bdf8dc836b4678508ec36772570eec
https://doi.org/10.2337/db20-2020-p
https://doi.org/10.2337/db20-2020-p
Publikováno v:
Diabetes. 69
Beyond enabling digestion of fats, bile acids (BA) are now known to be receptor ligands that improve glucose and lipoprotein metabolism. Classically, regulation of BA synthesis has thought to be exclusively hepatic, but emerging evidence in rodents i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1791f8d43c96ba68ff35e675e7a898f
https://doi.org/10.2337/db20-232-lb
https://doi.org/10.2337/db20-232-lb
Publikováno v:
JCI Insight
β3-Adrenergic receptors (β3-ARs) are the predominant regulators of rodent brown adipose tissue (BAT) thermogenesis. However, in humans, the physiological relevance of BAT and β3-AR remains controversial. Herein, using primary human adipocytes from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8759380da4475da6d896a4111f0153d9
https://pubmed.ncbi.nlm.nih.gov/34100382
https://pubmed.ncbi.nlm.nih.gov/34100382
Publikováno v:
BMC Medical Genomics
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-12 (2019)
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-12 (2019)
Background Neuroblastoma (NB) is the most common extracranial solid tumor found in children. The frequent gain/loss of many chromosome bands in tumor cells and absence of mutations found at diagnosis suggests that NB is a copy number-driven cancer. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a273f873e4aa9e5cee06b5c038ba197
http://europepmc.org/articles/PMC6909636
http://europepmc.org/articles/PMC6909636