Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Kenneth Y. Kwan"'
Autor:
Hao Liu, René N. Caballero-Florán, Ty Hergenreder, Tao Yang, Jacob M. Hull, Geng Pan, Ruonan Li, Macy W. Veling, Lori L. Isom, Kenneth Y. Kwan, Z. Josh Huang, Peter G. Fuerst, Paul M. Jenkins, Bing Ye
Publikováno v:
PLoS Biology, Vol 21, Iss 4 (2023)
Down syndrome (DS) is caused by the trisomy of human chromosome 21 (HSA21). A major challenge in DS research is to identify the HSA21 genes that cause specific symptoms. Down syndrome cell adhesion molecule (DSCAM) is encoded by a HSA21 gene. Previou
Externí odkaz:
https://doaj.org/article/74b66cc531524704bb62e3a0ac57b5a2
Autor:
Jason M. Keil, Daniel Z. Doyle, Adel Qalieh, Mandy M. Lam, Owen H. Funk, Yaman Qalieh, Lei Shi, Nitesh Mohan, Alice Sorel, Kenneth Y. Kwan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Chromatin mediates transcription and DNA repair. Here, the authors show distinct roles of chromatin remodeler INO80 in expression of YY1-regulated genes and repair of DNA breaks by homologous recombination, a DNA repair pathway important for symmetri
Externí odkaz:
https://doaj.org/article/340883430271499d8929db958f2df645
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The brain is a genomic mosaic shaped by somatic mutations and cellular responses that correct or purge these mutations. Here, by manipulating genome stability during embryonic brain development, authors revealed robust mechanisms that eliminate cells
Externí odkaz:
https://doaj.org/article/fc3234fbb7164890a3113aeffc7bddda
Autor:
Shigeki Iwase, Emily Brookes, Saurabh Agarwal, Aimee I. Badeaux, Hikaru Ito, Christina N. Vallianatos, Giulio Srubek Tomassy, Tomas Kasza, Grace Lin, Andrew Thompson, Lei Gu, Kenneth Y. Kwan, Chinfei Chen, Maureen A. Sartor, Brian Egan, Jun Xu, Yang Shi
Publikováno v:
Cell Reports, Vol 14, Iss 5, Pp 1000-1009 (2016)
Summary: Mutations in a number of chromatin modifiers are associated with human neurological disorders. KDM5C, a histone H3 lysine 4 di- and tri-methyl (H3K4me2/3)-specific demethylase, is frequently mutated in X-linked intellectual disability (XLID)
Externí odkaz:
https://doaj.org/article/8cb12d3238124adfb25be55f9e66ebd4
Autor:
Ikenna P. Njoku, Kenneth Y. Kwan
Publikováno v:
Neuron. 111:1168-1170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10f64bdd4f492cfbf6a97062c16accbc
https://doi.org/10.1016/j.neuron.2023.03.026
https://doi.org/10.1016/j.neuron.2023.03.026
Autor:
Tao Yang, Macy W. Veling, Xiao-Feng Zhao, Nicholas P. Prin, Limei Zhu, Ty Hergenreder, Hao Liu, Lu Liu, Zachary S. Rane, Masha G. Savelieff, Peter G. Fuerst, Qing Li, Kenneth Y. Kwan, Roman J. Giger, Yu Wang, Bing Ye
Publikováno v:
J Neurosci
During mammalian neocortex development, nascent pyramidal neurons migrate along radial glial cells and overtake earlier-born neurons to terminate at the front of the developing cortical plate (CP), leading to the outward expansion of the CP border. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e59a4812c375da2b6821018b0289b2
https://doi.org/10.1523/jneurosci.0997-21.2022
https://doi.org/10.1523/jneurosci.0997-21.2022
Autor:
Daniel Z, Doyle, Kenneth Y, Kwan
Publikováno v:
Nature neuroscience. 25(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00a91617374ce2b229eacda586057f9c
https://pubmed.ncbi.nlm.nih.gov/35726058
https://pubmed.ncbi.nlm.nih.gov/35726058
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
The brain is a genomic mosaic shaped by cellular responses to genome damage. Here, we manipulate somatic genome stability by conditional Knl1 deletion from embryonic mouse brain. KNL1 mutations cause microcephaly and KNL1 mediates the spindle assembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8059fb6aabc41fff983fd2ad8c5ce737
https://doaj.org/article/fc3234fbb7164890a3113aeffc7bddda
https://doaj.org/article/fc3234fbb7164890a3113aeffc7bddda
Autor:
Mandy M. Lam, Yaman Qalieh, Alice Sorel, Owen H. Funk, Kenneth Y. Kwan, Daniel Z. Doyle, Adel Qalieh
Publikováno v:
Proc Natl Acad Sci U S A
Loss-of-function mutations in chromatin remodeler gene ARID1A are a cause of Coffin-Siris syndrome, a developmental disorder characterized by dysgenesis of corpus callosum. Here, we characterize Arid1a function during cortical development and find un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6984e4c11f93b59a13dee63e73c0a07
https://europepmc.org/articles/PMC8166177/
https://europepmc.org/articles/PMC8166177/
Autor:
Daniel Z. Doyle, Adel Qalieh, Yaman Qalieh, Owen H. Funk, Kenneth Y. Kwan, Mandy M. Lam, Alice Sorel
Loss-of-function mutations in chromatin remodeler geneARID1Aare a cause of Coffin-Siris syndrome, a developmental disorder characterized by dysgenesis of corpus callosum. Here, we characterizeArid1afunction during cortical development and find unexpe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcc9aec3ba35bd74f68011a532157ae3
https://doi.org/10.1101/2020.12.14.422645
https://doi.org/10.1101/2020.12.14.422645