Evaluating COVID-19 vaccine effectiveness during pre-Delta, Delta and Omicron dominant periods among pregnant people in the U.S.: Retrospective cohort analysis from a nationally sampled cohort in National COVID Collaborative Cohort (N3C)

Autor: Nasia Safdar, Harold Lehmann, Jing Sun, Brijesh Patel, Hongfang Liu, Peter Robinson, Elaine Hill, Justin Guinney, Joel Gagnier, Cavin Ward-Caviness, Noha Sharafeldin, Justin Starren, Amit Saha, Lesley Cottrell, Melissa A Haendel, Vignesh Subbian, Kristin Kostka, Farrukh M Koraishy, Andrew E Williams, Robert Hurley, Steve Johnson, Usman Sheikh, Rishi Kamaleswaran, Christopher Dillon, Rena C Patel, Michele Morris, Randeep Jawa, Hemalkumar Mehta, Benjamin Bates, Tellen D Bennett, Nabeel Qureshi, Qiuyuan Qin, Kenneth Wilkins, Sara E Jones, Katie Rebecca Bradwell, Lauren Chan, Jerrod Anzalone, Qulu Zheng, Michael Liebman, Federico Mariona, Emily A Groene Faherty, Anup P Challa, Adam B Wilcox, Adam M Lee, Alexis Graves, Alfred Anzalone, Amin Manna, Amy Olex, Andrea Zhou, Andrew Southerland, Andrew T Girvin, Anita Walden, Anjali A Sharathkumar, Benjamin Amor, Brian Hendricks, Caleb Alexander, Caroline Signore, Carolyn Bramante, Charisse Madlock-Brown, Christine Suver, Christopher Chute, Chunlei Wu, Clare Schmitt, Cliff Takemoto, Dan Housman, Davera Gabriel, David A Eichmann, Diego Mazzotti, Eilis Boudreau Don Brown, Elizabeth Zampino, Emily Carlson Marti, Emily R Pfaff, Evan French, Fred Prior, George Sokos, Greg Martin, Heidi Spratt, Hythem Sidky, JW Awori Hayanga, Jami Pincavitch, Jaylyn Clark, Jeremy Richard Harper, Jessica Islam, Jin Ge, Joel H Saltz, Joel Saltz, Johanna Loomba, John Buse, Jomol Mathew, Joni L Rutter, Julie A McMurry, Karen Crowley, Kellie M Walters, Ken Wilkins, Kenneth R Gersing, Kenrick Dwain Cato, Kimberly Murray, Lavance Northington, Lee Allan Pyles, Leonie Misquitta, Lili Portilla, Mariam Deacy, Mark M Bissell, Marshall Clark, Mary Emmett, Mary Morrison Saltz, Matvey B Palchuk, Meredith Adams, Meredith Temple-O'Connor, Michael G Kurilla, Nicole Garbarini, Ofer Sadan, Patricia A Francis, Penny Wung Burgoon, Philip RO Payne, Rafael Fuentes, Rebecca Erwin-Cohen, Richard A Moffitt, Richard L Zhu, Robert T Miller, Saiju Pyarajan, Sam G Michael, Samuel Bozzette, Sandeep Mallipattu, Satyanarayana Vedula, Scott Chapman, T Shawn, Soko Setoguchi O'Neil, Stephanie S Hong, Tiffany Callahan, Umit Topaloglu, Valery Gordon, Warren A Kibbe, Wenndy Hernandez, Will Beasley, Will Cooper, William Hillegass, Xiaohan Tanner Zhang

Publikováno v: BMJ Public Health, Vol 2, Iss 1 (2024)

Objectives To evaluate the effectiveness of COVID-19 vaccinations (initial and booster) during pre-Delta, Delta and Omicron dominant periods among pregnant people via (1) COVID-19 incident and severe infections among pregnant people who were vaccinat

Externí odkaz: https://doaj.org/article/8dbc4ccf41e8439fbb2c1e6c27fb4854

Safety and immunogenicity of a recombinant Staphylococcus aureus α-toxoid and a recombinant Panton-Valentine leukocidin subunit, in healthy adults

Autor: Michael L. Landrum, Tahaniyat Lalani, Minoo Niknian, Jason D. Maguire, Duane R. Hospenthal, Ali Fattom, Kimberly Taylor, Jamie Fraser, Kenneth Wilkins, Michael W. Ellis, Paul D. Kessler, Rafaat E. F. Fahim, David R. Tribble

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 13, Iss 4, Pp 791-801 (2017)

We conducted a randomized, double-blind, placebo-controlled dose-escalation study in healthy adults to evaluate the safety and immunogenicity of recombinant Staphylococcus aureus candidate vaccine antigens, recombinant α-toxoid (rAT) and a sub-unit

Externí odkaz: https://doaj.org/article/01597b4a87634f8eb98a080d5a3c34fa

MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective.

Autor: Xiaonan Zhao, Yongwei Zhang, Kenneth Wilkins, Winfried Edelmann, Karen Usdin

Publikováno v: PLoS Genetics, Vol 14, Iss 10, p e1007719 (2018)

The Fragile X-related disorders (FXDs) are Repeat Expansion Diseases resulting from an expansion of a CGG-repeat tract at the 5' end of the FMR1 gene. The mechanism responsible for this unusual mutation is not fully understood. We have previously sho

Externí odkaz: https://doaj.org/article/7f1e17a8d8664fd7bbe97605c7c30466

Metformin is associated with reduced COVID-19 severity in patients with prediabetes

Autor: Lauren E. Chan, Elena Casiraghi, Bryan Laraway, Ben Coleman, Hannah Blau, Adnin Zaman, Nomi L. Harris, Kenneth Wilkins, Blessy Antony, Michael Gargano, Giorgio Valentini, David Sahner, Melissa Haendel, Peter N. Robinson, Carolyn Bramante, Justin Reese

Publikováno v: medRxiv, vol 3, iss 09-09

BackgroundWith the continuing COVID-19 pandemic, identifying medications that improve COVID-19 outcomes is crucial. Studies suggest that use of metformin, an oral antihyperglycemic, is associated with reduced COVID-19 severity in individuals with dia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7795d557e78931fb3d6cc5ce367d0826
https://pubmed.ncbi.nlm.nih.gov/36093353

A Machine Learning Model for Predicting Mortality within 90 Days of Dialysis Initiation

Autor: Summer Rankin, Lucy Han, Rebecca Scherzer, Susan Tenney, Matthew Keating, Kimberly Genberg, Matthew Rahn, Kenneth Wilkins, Michael Shlipak, Michelle Estrella

Publikováno v: Kidney360
Kidney360, vol 3, iss 9

BACKGROUND: The first 90 days after dialysis initiation are associated with high morbidity and mortality in end-stage kidney disease (ESKD) patients. A machine learning–based tool for predicting mortality could inform patient-clinician shared decis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66ae196fdd76f75b9c8091d4b8c98fa0
https://pubmed.ncbi.nlm.nih.gov/36245665