Výsledky vyhledávání - "Kenneth W. Porter"

SYNTHESIS AND PROPERTIES OF NOVEL TRIPHOSPHATE ANALOGUES: RIBONUCLEOSIDE AND DEOXYRIBONUCLEOSIDE (α-P-BORANO, α-P-THIO)TRIPHOSPHATES

Autor: Kenneth W. Porter, Jinlai Lin, Barbara Ramsay Shaw

Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 20:1019-1023

The first ribo- and deoxyribo-nucleoside (alpha-P-borano, alpha-P-thio)triphosphates have been synthesized. The chemical and biochemical properties of adenosine (alpha-P-borano, alpha-P-thio)triphosphate and thymidine (alpha-P-borano, alpha-P-thio) t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65862e8968a7a7a48fccc0e1fac02a1
https://doi.org/10.1081/ncn-100002482

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Direct PCR Sequencing with Boronated Nucleotides

Autor: Kenneth W. Porter, Barbara Ramsay Shaw, J. David Briley

Publikováno v: Nucleic Acids Research. 25:1611-1617

A method is described to simultaneously amplify and sequence DNA using a new class of nucleotides containing boron. During the polymerase chain reaction, boron-modified nucleotides, i.e. 2'-deoxynucleoside 5'-alpha-[P-borano]-triphosphates, are incor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7f7931f7d1d4395c7a1b7f2d58714a
https://doi.org/10.1093/nar/25.8.1611

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N7-Cyanoborane-2'-Deoxyguanosine 5'-Triphosphate Is a Good Substrate for DNA Polymerase

Autor: Anup Sood, Kenneth W. Porter, Jeno Tomasz, Faqing Huang, Barbara Ramsay Shaw

Publikováno v: Biochemistry. 34:11963-11969

The 5{sup {prime}}-triphosphate of the boronated nucleoside analog N{sup 7}-cyanoborane-w{sup 2}-deoxyguanosine ({sup 7b}dGTP) was synthesized, and a series of experiments was initiated to assess the potential of the compound to serve as a substrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e41c821921768a665a403012a41ab31b
https://doi.org/10.1021/bi00037a038

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Synthesis of 5-substituted 2'-deoxycytidine 5'-(alpha-P-borano)triphosphates, their incorporationinto DNA and effects on exonuclease

Autor: Barbara Ramsay Shaw, Kenneth W. Porter, J. David Briley, Kaizhang He, Ahmad Hasan

Direct PCR sequencing with boronated nucleotides provides an alternative to current PCR sequencing methods. The positions of boranophosphate-modified nucleotides incorporated randomly into DNA during PCR can be revealed directly by exonuclease digest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8ad9695df12781062c95739deca741
https://europepmc.org/articles/PMC148385/

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Boron-containing oligodeoxyribonucleotide 14mer duplexes: enzymatic synthesis and melting studies

Autor: Kenneth W. Porter, Faqing Huang, Hong Li, Barbara Ramsay Shaw

A set of three 14mer oligodeoxyribonucleotides of sequence d(5'-CTATGGCCTCAG*CT-3'/3'-GATACCGGAGTCGA-5') containing G* variants either as 2'-deoxyguanosine phosphate (unmodified), N7-cyanoborane 2'-deoxyguanosine phosphate (base-modified) or 2'-deoxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd4f1601150ad8441a86fe2d3c6b4bb
https://europepmc.org/articles/PMC307409/

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