Fibroblast activation protein drives tumor metastasis via a protease-independent role in invadopodia stabilization

Autor: Maurish Bukhari, Navneeta Patel, Rosa Fontana, Miguel Santiago-Medina, Yike Jiang, Dongmei Li, Kersi Pestonjamasp, Victoria J. Christiansen, Kenneth W. Jackson, Patrick A. McKee, Jing Yang

Publikováno v: Cell Reports, Vol 42, Iss 10, Pp 113302- (2023)

Summary: During metastasis, tumor cells invade through the basement membrane and intravasate into blood vessels and then extravasate into distant organs to establish metastases. Here, we report a critical role of a transmembrane serine protease fibro

Externí odkaz: https://doaj.org/article/9eb9fb7b177049c08be28a366975d681

Targeting Inhibition of Fibroblast Activation Protein-α and Prolyl Oligopeptidase Activities on Cells Common to Metastatic Tumor Microenvironments

Autor: Victoria J. Christiansen, Kenneth W. Jackson, Kyung N. Lee, Tamyra D. Downs, Patrick A. McKee

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 4, Pp 348-358 (2013)

Fibroblast activation protein (FAP), a membrane prolyl-specific proteinase with both dipeptidase and endopeptidase activities, is overexpressed by reactive stromal fibroblasts during epithelial-derived cancer growth. FAP digests extracellular matrix

Externí odkaz: https://doaj.org/article/cdf915a2f39f4917a8fb8c88ccb4b310

Supplemental tables and figures from NetH2pan: A Computational Tool to Guide MHC Peptide Prediction on Murine Tumors

Autor: William H. Hildebrand, Morten Nielsen, Alana L. Welm, Kenneth W. Jackson, Vanessa I. Jurtz, Steven J. Cate, Wilfried Bardet, Massimo Andreatta, Christa I. DeVette

Supplemental Table S1: AUC and PPV for NetH2pan network ensemble Supplemental Table S2: AUC and PPV for prediction of ligands by NetH2pan, trained with or without sequence context of five residues flanking the peptide. Supplemental Table S3. Yield (#

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6616f4997ea72dbc15e849566e088011
https://doi.org/10.1158/2326-6066.22539344

Suppression of Tumor Growth in Mice by Rationally Designed Pseudopeptide Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase

Autor: Roy Zhang, Kenneth W. Jackson, Patrick A. McKee, Victoria J. Christiansen, Robert Silasi-Mansat, Vibhudutta Awasthi, Florea Lupu, Vivek R. Yadav

Publikováno v: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 1, Pp 43-54 (2015)

Tumor microenvironments (TMEs) are composed of cancer cells, fibroblasts, extracellular matrix, microvessels, and endothelial cells. Two prolyl endopeptidases, fibroblast activation protein (FAP) and prolyl oligopeptidase (POP), are commonly overexpr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7b739ef3595dc201ef850ce8b80539

The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands

Autor: William H. Hildebrand, Philip Robinson, Wilfred Bardet, David A. Bushnell, Jeroen H. Blokhuis, Juan L. Mendoza, Lisbeth A. Guethlein, Alex S. Han, Hugo G. Hilton, Morten Nielsen, Zakia Djaoud, Michael E. Birnbaum, Amir Horowitz, Jason L. Pugh, K. Christopher Garcia, Curtis McMurtrey, Rico Buchli, Kenneth W. Jackson, Ana Goyos, Peter Parham

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Hilton, H G, McMurtrey, C P, Han, A S, Djaoud, Z, Guethlein, L A, Blokhuis, J H, Pugh, J L, Goyos, A, Horowitz, A, Buchli, R, Jackson, K W, Bardet, W, Bushnell, D A, Robinson, P J, Mendoza, J L, Birnbaum, M E, Nielsen, M, Garcia, K C, Hildebrand, W H & Parham, P 2017, ' The Intergenic Recombinant HLA-B*46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands ', Cell Reports, vol. 19, no. 7, pp. 1394-1405 . https://doi.org/10.1016/j.celrep.2017.04.059
Cell Reports
Cell Reports, Vol 19, Iss 7, Pp 1394-1405 (2017)

HLA-B∗46:01 was formed by an intergenic mini-conversion, between HLA-B∗15:01 and HLA-C∗01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad35a02bff1fcb0d4d600bc391ba9145
https://pubmed.ncbi.nlm.nih.gov/28514659