Zobrazeno 1 - 10 of 366 pro vyhledávání: '"Kenneth W Harder"'
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Akademický článek
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases.
Autor: Marina Tiemi Shio, Stephanie C Eisenbarth, Myriam Savaria, Adrien F Vinet, Marie-Josée Bellemare, Kenneth W Harder, Fayyaz S Sutterwala, D Scott Bohle, Albert Descoteaux, Richard A Flavell, Martin Olivier
Publikováno v: PLoS Pathogens, Vol 5, Iss 8, p e1000559 (2009)
The intraerythrocytic parasite Plasmodium -- the causative agent of malaria -- produces an inorganic crystal called hemozoin (Hz) during the heme detoxification process, which is released into the circulation during erythrocyte lysis. Hz is rapidly i
Externí odkaz: https://doaj.org/article/b98814ba35b5496b9d4c9d2461d8a623
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2
Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling
Autor: Israel Matos, Maunish Barvalia, Manreet K. Chehal, A. Gordon Robertson, Iva Kulic, Jessica A.F.D. Silva, Abhinandan Ranganathan, Amy Short, Yu-Hsuan Huang, Erin Long, John J. Priatel, Salim Dhanji, Brad H. Nelson, Danielle L. Krebs, Kenneth W. Harder
Publikováno v: Cancer Research Communications. 3:404-419
While immunotherapies such as immune checkpoint blockade and adoptive T-cell therapy improve survival for a subset of human malignancies, many patients fail to respond. Phagocytes including dendritic cells (DC), monocytes, and macrophages (MF) orches
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c58b03e0d87c5b4e0ad543399513670
https://doi.org/10.1158/2767-9764.crc-22-0278
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7
Data from Dysregulated Hematopoiesis Caused by Mammary Cancer Is Associated with Epigenetic Changes and Hox Gene Expression in Hematopoietic Cells
Autor: Kenneth W. Harder, Danielle L. Krebs, Tomasz Cierpicki, Jolanta Grembecka, Brad H. Nelson, Morgan E. Roberts, Xueling Fan, Kevin Tsai, Manreet K. Chehal, Alexander Sio
Cancer is associated with immune dysfunction characterized by the presence of proinflammatory and immunosuppressive cells and factors that contribute to tumor growth and progression. Here we show that mammary tumor growth is associated with defects i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1ab1d44a57173c59ef8c3900f46865
https://doi.org/10.1158/0008-5472.c.6504621
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8
An End-to-End Workflow for Interrogating Tumor-Infiltrating Myeloid Cells Using Mass Cytometry
Autor: Maunish, Barvalia, Kenneth W, Harder
Publikováno v: Methods in molecular biology (Clifton, N.J.). 2508
Myeloid cells are a highly heterogeneous group of innate immune cells which include a diverse collection of cell types and cell states. Distinct subsets can impact tumor progression differently, with conventional type 1 DCs important in protective an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf5a4e36f173117d75de382b1e1ec62c
https://pubmed.ncbi.nlm.nih.gov/35737239
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9
Cutting Edge: Intestinal Mucus Limits the Clonal Deletion of Developing T Cells Specific for an Oral Antigen
Autor: Yu-Hsuan Huang, Kevin Tsai, Bruce A. Vallance, Troy A. Baldwin, Kenneth W. Harder, Caixia Ma, John J. Priatel
Publikováno v: The Journal of Immunology. 205:329-334
A layer of mucus functions to segregate contents of the intestinal lumen from the intestinal epithelium. The MUC2 mucin is the primary constituent of intestinal mucus and plays critical protective roles against luminal microbes and other noxious agen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b2aff73aa29137ec96d715819b926e
https://doi.org/10.4049/jimmunol.1900687
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