Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Kenneth W Gross"'
Autor:
Prashant Kumar, Fahad Zadjali, Ying Yao, Daniel Johnson, Brian Siroky, Aristotelis Astrinidis, Peter Vogel, Kenneth W. Gross, John J. Bissler
Publikováno v:
Genes and Diseases, Vol 9, Iss 1, Pp 187-200 (2022)
TSC renal cystic disease is poorly understood and has no approved treatment. In a new principal cell-targeted murine model of Tsc cystic disease, the renal cystic epithelium is mostly composed of type A intercalated cells with an intact Tsc2 gene con
Externí odkaz:
https://doaj.org/article/e9af695b73a243cab858e93e553b7277
Autor:
Christopher J. Greene, Kristopher Attwood, Nitika J. Sharma, Benjamin Balderman, Rongia Deng, Jason B. Muhitch, Gary J. Smith, Kenneth W. Gross, Bo Xu, Eric C. Kauffman
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Iron is a potent catalyst of oxidative stress and cellular proliferation implicated in renal cell carcinoma (RCC) tumorigenesis, yet it also drives ferroptosis that suppresses cancer progression and represents a novel therapeutic target for advanced
Externí odkaz:
https://doaj.org/article/f6b91ca2c5c249dc9afb505e6f186f2e
Autor:
Prashant Kumar, Fahad Zadjali, Ying Yao, Brian Siroky, Aristotelis Astrinidis, Kenneth W. Gross, John J. Bissler
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
In tuberous sclerosis complex (TSC), Tsc2 mutations are associated with more severe disease manifestations than Tsc1 mutations and the role of extracellular vesicles (EVs) in this context is not yet studied. We report a comparative analysis of EVs de
Externí odkaz:
https://doaj.org/article/cfd84fb97743434386200feaede95852
Autor:
Prashant Kumar, Fahad Zadjali, Ying Yao, Michael Köttgen, Alexis Hofherr, Kenneth W. Gross, Darshan Mehta, John J. Bissler
Publikováno v:
Biology, Vol 11, Iss 5, p 709 (2022)
Patients with autosomal dominant polycystic kidney disease (ADPKD) and tuberous sclerosis complex (TSC) are born with normal or near-normal kidneys that later develop cysts and prematurely lose function. Both renal cystic diseases appear to be mediat
Externí odkaz:
https://doaj.org/article/1dbb8840bd5444d7bdfb49117c6c5786
Autor:
Natalya V. Kaverina, Diana G. Eng, Andrea D. Largent, Ilse Daehn, Anthony Chang, Kenneth W. Gross, Jeffrey W. Pippin, Peter Hohenstein, Stuart J. Shankland
Publikováno v:
Stem Cell Reports, Vol 9, Iss 4, Pp 1152-1166 (2017)
Wilms' tumor suppressor 1 (WT1) plays an important role in cell proliferation and mesenchymal-epithelial balance in normal development and disease. Here, we show that following podocyte depletion in three experimental models, and in patients with foc
Externí odkaz:
https://doaj.org/article/baa074c6b6234a0c8dc9b18339e657b9
Autor:
Aristotelis Astrinidis, John J. Bissler, Ying Yao, Fahad Zadjali, Daniel L. Johnson, Prashant Kumar, Kenneth W. Gross, Peter Vogel, Brian Siroky
Publikováno v:
Genes and Diseases, Vol 9, Iss 1, Pp 187-200 (2022)
Genes & Diseases
Genes & Diseases
TSC renal cystic disease is poorly understood and has no approved treatment. In a new principal cell-targeted murine model of Tsc cystic disease, the renal cystic epithelium is mostly composed of type A intercalated cells with an intact Tsc2 gene con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30778696e06d508bbfe267757da40013
https://doi.org/10.1016/j.gendis.2021.03.010
https://doi.org/10.1016/j.gendis.2021.03.010
Autor:
Aaron D McClelland, Julia Lichtnekert, Diana G Eng, Jeffrey W Pippin, Kenneth W Gross, Sina A Gharib, Stuart J Shankland
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189084 (2017)
Renin producing cells of the juxtaglomerulus, herein called cells of renin lineage (CoRL), have garnered recent interest for their propensity to act as a progenitor source for various kidney cell types including podocytes. Despite recent advances, th
Externí odkaz:
https://doaj.org/article/777ee5d35f244b0cb6259e84c58ef626
Autor:
Natalya V Kaverina, Hiroyuki Kadoya, Diana G Eng, Michael E Rusiniak, Maria Luisa S Sequeira-Lopez, R Ariel Gomez, Jeffrey W Pippin, Kenneth W Gross, Janos Peti-Peterdi, Stuart J Shankland
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173891 (2017)
Podocyte depletion plays a major role in focal segmental glomerular sclerosis (FSGS). Because cells of the renin lineage (CoRL) serve as adult podocyte and parietal epithelial cell (PEC) progenitor candidates, we generated Ren1cCre/R26R-ConfettiTG/WT
Externí odkaz:
https://doaj.org/article/377f11c06fb4421e8b9d0334feb3b70e
Autor:
Loïs van der Pluijm, Angela Koudijs, Wendy Stam, Joris Rotmans, Kenneth W Gross, Michael Paul Pieper, Anton Jan van Zonneveld, Roel Bijkerk
Publikováno v:
Nephrology Dialysis Transplantation. 37
BACKGROUND AND AIMS With chronic kidney disease (CKD) prevalence rapidly increasing, the need for novel therapies is rising. Sodium glucose co-transporter-2 (SGLT2) inhibitors were originally developed to treat hyperglycemia in patients with type 2 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::320f41b697ac8f69b82e6cc07d58fda9
https://doi.org/10.1093/ndt/gfac063.026
https://doi.org/10.1093/ndt/gfac063.026
Publikováno v:
BioTechniques, Vol 43, Iss 5, Pp 639-647 (2007)
Formalin-fixed paraffin-embedded (FFPE) tissues are routinely stored by most pathology departments and are a widely available resource for discovery of clinically useful biomarkers. We describe our method for optimizing quantitative reverse transcrip
Externí odkaz:
https://doaj.org/article/7d31261292f34af39b0178fd9ad58db8