Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kenneth W Foreman"'
Autor:
Bryan M. Delfing, Xavier E. Laracuente, Xingyu Luo, Audrey Olson, William Jeffries, Kenneth W. Foreman, Mikell Paige, Kylene Kehn-Hall, Christopher Lockhart, Dmitri K. Klimov
Publikováno v:
ACS Omega, Vol 9, Iss 38, Pp 40259-40268 (2024)
Externí odkaz:
https://doaj.org/article/fa808101ebc248e1b00e2437d38b4502
Autor:
Kenneth W Foreman
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188134 (2017)
Empirical data has shown that bivalent inhibitors can bind a given target protein significantly better than their monomeric counterparts. However, predicting the corresponding theoretical fold improvements has been challenging. The current work build
Externí odkaz:
https://doaj.org/article/ae7c7eee96044232a17ea14e9b68359b
Autor:
Jutta Wanner, Darlene Romashko, Douglas S Werner, Earl W May, Yue Peng, Ryan Schulz, Kenneth W Foreman, Suzanne Russo, Lee D Arnold, Maneesh Pingle, Donald E Bergstrom, Francis Barany, Stuart Thomson
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121793 (2015)
We describe the successful application of a novel approach for generating dimeric Myc inhibitors by modifying and reversibly linking two previously described small molecules. We synthesized two directed libraries of monomers, each comprised of a liga
Externí odkaz:
https://doaj.org/article/a96fd43cf1cf4560b2de89acf1760b8b
Autor:
Kenneth W Foreman, Mark Brown, Frances Park, Spencer Emtage, June Harriss, Chhaya Das, Li Zhu, Andy Crew, Lee Arnold, Salam Shaaban, Philip Tucker
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22290 (2011)
The SET and MYND Domain (SMYD) proteins comprise a unique family of multi-domain SET histone methyltransferases that are implicated in human cancer progression. Here we report an analysis of the crystal structure of the full length human SMYD3 in a c
Externí odkaz:
https://doaj.org/article/8a5e03af3211429fbe1dc1ff4855df90
Autor:
Bryan M. Delfing, Audrey Olson, Xavier E. Laracuente, Kenneth W. Foreman, Mikell Paige, Kylene Kehn-Hall, Christopher Lockhart, Dmitri K. Klimov
Publikováno v:
The Journal of Physical Chemistry B. 127:3175-3186
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74b3b6e1c32d42c54fb17d4e24c024b4
https://doi.org/10.1021/acs.jpcb.3c00429
https://doi.org/10.1021/acs.jpcb.3c00429
Autor:
Kyung Hyeon, Lee, Nadia Fazal, Ali, Soo Hyeon, Lee, Zhimin, Zhang, Marie, Burdick, Zachary J, Beaulac, Greg, Petruncio, Linxia, Li, Jiangdong, Xiang, Ezra M, Chung, Kenneth W, Foreman, Schroeder M, Noble, Yun M, Shim, Mikell, Paige
Publikováno v:
Scientific reports. 12(1)
The aminopeptidase activity (AP) of the leukotriene A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a53b0c62b6a8ce1f296d547c3980c676
https://pubmed.ncbi.nlm.nih.gov/35676292
https://pubmed.ncbi.nlm.nih.gov/35676292
Autor:
Sarah F. Giardina, Douglas S. Werner, Maneesh Pingle, Philip B. Feinberg, Kenneth W. Foreman, Donald E. Bergstrom, Lee D. Arnold, Francis Barany
Publikováno v:
Journal of medicinal chemistry. 63(6)
β-Tryptase, a homotetrameric serine protease, has four identical active sites facing a central pore, presenting an optimized setting for the rational design of bivalent inhibitors that bridge two adjacent sites. Using diol, hydroxymethyl phenols or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e5070c5aa57547e015befeca85ada5
https://pubmed.ncbi.nlm.nih.gov/32057241
https://pubmed.ncbi.nlm.nih.gov/32057241
Autor:
Douglas S. Werner, Lee D. Arnold, Maneesh Pingle, Donald E. Bergstrom, Kenneth W. Foreman, Sarah F Giardina, Francis Barany
Publikováno v:
ACS Medicinal Chemistry Letters
Tryptase, a serine protease released from mast cells, is implicated in many allergic and inflammatory disorders. Human tryptase is a donut-shaped tetramer with the active sites facing inward forming a central pore. Bivalent ligands spanning two activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d226169ab9fee6ac95d8f5adba737956
https://doi.org/10.1021/acsmedchemlett.8b00204
https://doi.org/10.1021/acsmedchemlett.8b00204
Autor:
Chhaya Das, Mark A. Brown, Melissa A. Edwards, Li Zhu, June V. Harriss, Haley O. Tucker, Kenneth W. Foreman, Salam Shaaban
Publikováno v:
Oncotarget
// Mark A. Brown 1, * , Kenneth Foreman 2, * , June Harriss 3 , Chhaya Das 3 , Li Zhu 3 , Melissa Edwards 1, 3 , Salam Shaaban 4 , Haley Tucker 3 1 Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA 2 Coferon Inc.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780030f15dda598155f0911c2dae9545
http://europepmc.org/articles/PMC4414169
http://europepmc.org/articles/PMC4414169
Autor:
Kenneth W. Foreman, David V. Erbe, Yan-Ling Zhang, Steven J. Kirincich, Zhao-Kui Wan, Alessandro Moretto, Eva Binnun, Douglas P. Wilson, Tam Steve Yik-Kai, S.K. Tam, Bruce Follows, Weixin Xu, Diane Joseph-McCarthy, Julie Lee, Michael J. Smith
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:2162-2177
A novel pyridothiophene inhibitor of PTP1B was discovered by rational screening of phosphotyrosine mimics at high micromolar concentrations. The potency of this lead compound has been improved significantly by medicinal chemistry guided by X-ray crys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f3ea9825417e657d8eab4182b3f9bb
https://doi.org/10.1016/j.bmc.2005.11.005
https://doi.org/10.1016/j.bmc.2005.11.005