Zobrazeno 1 - 10 of 38 pro vyhledávání: '"Kenneth W, Walker"'
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Akademický článek
Pharmacokinetic comparison of a diverse panel of non-targeting human antibodies as matched IgG1 and IgG2 isotypes in rodents and non-human primates.
Autor: Kenneth W Walker, Hossein Salimi-Moosavi, Gregory E Arnold, Qing Chen, Marcus Soto, Frederick W Jacobsen, John Hui
Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0217061 (2019)
In this study we compared the pharmacokinetic profile of four unrelated antibodies, which do not bind to mammalian antigens, in IgG1 and IgG2 frameworks in both rats and non-human primates (NHP). This allowed for extensive cross comparison of the imp
Externí odkaz: https://doaj.org/article/14136c151f2d4a898ef46dc3efe9bd87
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4
The serum protein transthyretin as a platform for dimerization and tetramerization of antibodies and Fab fragments to enable target clustering
Autor: Kenneth W. Walker, Ian Foltz, Hossein Salimi-Moosavi, Richele Bruno, Fei Lee, Zhulun Wang, Julie M. Bailis, Stephen Smith, Tina Wang, Phillip An
Publikováno v: J Biol Chem
Transthyretin (TTR) is an abundant homotetrameric serum protein and was selected here for engineering higher-valency molecules because of its compact size, simple structure, and natural propensity to tetramerize. To demonstrate this utility, we fused
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec51fc0568cbbb6b6da4786f5d17f8f
https://doi.org/10.1074/jbc.ra120.013135
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Transthyretin-mediated protein and peptide oligomerization for enhanced target clustering
Autor: Daniel Yoo, Kenneth W. Walker
Publikováno v: Emerging topics in life sciences. 5(5)
Advances in cancer research have led to the development of new therapeutics with significant and durable responses such as immune checkpoint inhibitors. More recent therapies aim to stimulate anti-tumor immune responses by targeting the tumor necrosi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b0b324e3dbdd4de12ff32f09dd53a8
https://pubmed.ncbi.nlm.nih.gov/34282847
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7
High-resolution mass spectrometry confirms the presence of a hydroxyproline (Hyp) post-translational modification in the GGGGP linker of an Fc-fusion protein
Autor: Stone D.-H. Shi, Kannan Gunasekaran, Chris Spahr, Kenneth W. Walker
Publikováno v: mAbs. 9:812-819
Flexible and protease resistant (G4S)n linkers are used extensively in protein engineering to connect various protein domains. Recently, several groups have observed xylose-based O-glycosylation at linker Ser residues that yield unwanted heterogeneit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14a75f9f95edd772a9fd5c2902d2f56
https://doi.org/10.1080/19420862.2017.1325556
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Engineering an IgG Scaffold Lacking Effector Function with Optimized Developability
Autor: Quanzhou Luo, Kenneth W. Walker, Qing Chen, Kannan Gunasekaran, Riki Stevenson, Jie Wen, Frederick W. Jacobsen, Shu-Yin Ho, Lynette Buck, Linda O. Narhi, Kristine M. Daris, Wei Wang, Jette Wypych, Hossein Salimi-Moosavi, Sterling Miller, Ling Liu, Cynthia Li
Publikováno v: Journal of Biological Chemistry. 292:1865-1875
IgG isotypes can differentially bind to Fcγ receptors and complement, making the selection of which isotype to pursue for development of a particular therapeutic antibody important in determining the safety and efficacy of the drug. IgG2 and IgG4 is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2cf1364e96ab1f3b6912d3a7576cf4
https://doi.org/10.1074/jbc.m116.748525
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9
Development of BioRad NGC and GE ÄKTA pure systems for highly automated three column protein purification employing tandem affinity, buffer exchange and size exclusion chromatography
Autor: Daniel Yoo, Dwight Winters, Kenneth W. Walker, Mai Tran
Publikováno v: Protein expression and purification. 165
Affinity purification, such as Protein A (ProA) followed by size exclusion chromatography (SEC) remains a popular method to obtain research scale proteins. With the need for higher throughput protein production increasing for discovery research, ther
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5057ce736847cff798bfa9bb0fa9bd82
https://pubmed.ncbi.nlm.nih.gov/31499166
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A High-Throughput Automated Protein Folding System
Autor: Kenneth W, Walker, Philip, An, Dwight, Winters
Publikováno v: Methods in molecular biology (Clifton, N.J.). 2025
In vitro protein folding can be employed to produce complex proteins expressed as insoluble inclusion bodies in E. coli from laboratory to commercial scale. Often the most challenging step is identification of renaturation conditions that will enable
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96024526abd10af79caa3c909cd03af9
https://pubmed.ncbi.nlm.nih.gov/31267451
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