Zobrazeno 1 - 10
of 475
pro vyhledávání: '"Kenneth W, Kinzler"'
Autor:
Katharine M. Wright, Sarah R. DiNapoli, Michelle S. Miller, P. Aitana Azurmendi, Xiaowei Zhao, Zhiheng Yu, Mayukh Chakrabarti, WuXian Shi, Jacqueline Douglass, Michael S. Hwang, Emily Han-Chung Hsiue, Brian J. Mog, Alexander H. Pearlman, Suman Paul, Maximilian F. Konig, Drew M. Pardoll, Chetan Bettegowda, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Shibin Zhou, Sandra B. Gabelli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Specificity remains a major challenge to current therapeutic strategies for cancer. Mutation associated neoantigens (MANAs) are products of genetic alterations, making them highly specific therapeutic targets. MANAs are HLA-presented (pHLA)
Externí odkaz:
https://doaj.org/article/5c61b5ab3e274b5e8cb75d96c8090383
Autor:
Steve Lu, Austin K. Mattox, P. Aitana Azurmendi, Ilias Christodoulou, Katharine M. Wright, Maria Popoli, Zan Chen, Surojit Sur, Yana Li, Challice L. Bonifant, Chetan Bettegowda, Nickolas Papadopoulos, Shibin Zhou, Sandra B. Gabelli, Bert Vogelstein, Kenneth W. Kinzler
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
The covid pandemic has highlighted the need for rapid antibody development. Here, authors develop an approach called SLISY, which uses NGS with phage display to simultaneously assess millions of clones to rapidly isolate specific antibodies against S
Externí odkaz:
https://doaj.org/article/1dcb103877994cf8b3292eb0a55e545d
Autor:
Michael S. Hwang, Michelle S. Miller, Puchong Thirawatananond, Jacqueline Douglass, Katharine M. Wright, Emily Han-Chung Hsiue, Brian J. Mog, Tihitina Y. Aytenfisu, Michael B. Murphy, P. Aitana Azurmendi, Andrew D. Skora, Alexander H. Pearlman, Suman Paul, Sarah R. DiNapoli, Maximilian F. Konig, Chetan Bettegowda, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Shibin Zhou, Sandra B. Gabelli
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Chimeric antigen receptor T cells in the clinic currently target cell-type-specific extracellular antigens on malignant cells. Here, authors engineer tumor-specific chimeric antigen receptor T cells that target human leukocyte antigen-presented neoan
Externí odkaz:
https://doaj.org/article/fff72ea490f640af8b0aeee032442ea5
Autor:
Ashley L. Cook, Nicolas Wyhs, Surojit Sur, Blair Ptak, Maria Popoli, Laura Dobbyn, Tasos Papadopoulos, Chetan Bettegowda, Nickolas Papadopoulos, Bert Vogelstein, Shibin Zhou, Kenneth W. Kinzler
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104437- (2022)
Summary: We describe the creation of an isogenic cell line panel representing common cancer pathways, with features optimized for high-throughput screening. More than 1,800 cell lines from three normal human cell lines were generated using CRISPR tec
Externí odkaz:
https://doaj.org/article/372f67ce56564615a5e03deb5b7a7da3
Autor:
Nickolas Papadopoulos, Chen Hu, Julie R Brahmer, Patrick M Forde, Evan J Lipson, Jarushka Naidoo, Wei Fu, Joanne Riemer, Chetan Bettegowda, Cesar A Santa-Maria, Matthias Holdhoff, Amanda Barnes, Nafi Aygun, Lawrence Kleinberg, Christopher Douville, Arun Venkatesan, Karisa C Schreck, Alexander Carvajal-Gonzalez, Roisin M Connolly, Kristin J Redmond, Brandi Page, Kenneth W Kinzler, Stuart A Grossman
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
Background The benefit of immune checkpoint inhibitors (ICIs) in patients with leptomeningeal metastases (LMM) is unknown.Methods We undertook a phase II trial of pembrolizumab in patients with LMM from solid tumors. Eligible patients had radiologic/
Externí odkaz:
https://doaj.org/article/5144d6053e5e4af9b489cd9937834ab8
Autor:
Kellie N. Smith, Nicolas J. Llosa, Tricia R. Cottrell, Nicholas Siegel, Hongni Fan, Prerna Suri, Hok Yee Chan, Haidan Guo, Teniola Oke, Anas H. Awan, Franco Verde, Ludmila Danilova, Valsamo Anagnostou, Ada J. Tam, Brandon S. Luber, Bjarne R. Bartlett, Laveet K. Aulakh, John-William Sidhom, Qingfeng Zhu, Cynthia L. Sears, Leslie Cope, William H. Sharfman, Elizabeth D. Thompson, Joanne Riemer, Kristen A. Marrone, Jarushka Naidoo, Victor E. Velculescu, Patrick M. Forde, Bert Vogelstein, Kenneth W. Kinzler, Nickolas Papadopoulos, Jennifer N. Durham, Hao Wang, Dung T. Le, Sune Justesen, Janis M. Taube, Luis A. Diaz, Julie R. Brahmer, Drew M. Pardoll, Robert A. Anders, Franck Housseau
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-8 (2019)
Abstract Background Several predictive biomarkers are currently approved or are under investigation for the selection of patients for checkpoint blockade. Tumor PD-L1 expression is used for stratification of non-small cell lung (NSCLC) patients, with
Externí odkaz:
https://doaj.org/article/1bbf8602f6f8428183fdc7d49f984cca
Autor:
Gary L. Gallia, Ming Zhang, Yi Ning, Michael C. Haffner, Denise Batista, Zev A. Binder, Justin A. Bishop, Christine L. Hann, Ralph H. Hruban, Masaru Ishii, Alison P. Klein, Douglas D. Reh, Lisa M. Rooper, Vafi Salmasi, Rafael J. Tamargo, Qing Wang, Tara Williamson, Tianna Zhao, Ying Zou, Alan K. Meeker, Nishant Agrawal, Bert Vogelstein, Kenneth W. Kinzler, Nickolas Papadopoulos, Chetan Bettegowda
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
Olfactory neuroblastoma (ONB) is a rare malignant tumor whose genetic basis is poorly understood. Here the authors identify recurrent deletions involving dystrophin in the majority of ONB patient tumors examined.
Externí odkaz:
https://doaj.org/article/666203899eb144b58109b82017f4bbe7
Autor:
Jeanne Tie, Yuxuan Wang, Joshua Cohen, Lu Li, Wei Hong, Michael Christie, Hui Li Wong, Suzanne Kosmider, Rachel Wong, Benjamin Thomson, Julian Choi, Adrian Fox, Kathryn Field, Matthew Burge, Jenny Shannon, Dusan Kotasek, Niall C Tebbutt, Christos Karapetis, Craig Underhill, Andrew Haydon, Joy Schaeffer, Janine Ptak, Cristian Tomasetti, Nicholas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein, Peter Gibbs
Publikováno v:
PLoS Medicine, Vol 18, Iss 5, p e1003620 (2021)
BackgroundIn patients with resectable colorectal liver metastases (CRLM), the role of pre- and postoperative systemic therapy continues to be debated. Previous studies have shown that circulating tumor DNA (ctDNA) analysis, as a marker of minimal res
Externí odkaz:
https://doaj.org/article/5fefae544f494349b57c0bd567ac52e2
Autor:
Liam Rose, Laura Graham, Allison Koenecke, Michael Powell, Ruoxuan Xiong, Zhu Shen, Brett Mench, Kenneth W. Kinzler, Chetan Bettegowda, Bert Vogelstein, Susan Athey, Joshua T. Vogelstein, Maximilian F. Konig, Todd H. Wagner
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Effective therapies for coronavirus disease 2019 (COVID-19) are urgently needed, and pre-clinical data suggest alpha-1 adrenergic receptor antagonists (α1-AR antagonists) may be effective in reducing mortality related to hyperinflammation independen
Externí odkaz:
https://doaj.org/article/ab4b9d51ba514d2ba03c96c9867208a1
Autor:
Jeanne, Tie, Joshua D, Cohen, Kamel, Lahouel, Serigne N, Lo, Yuxuan, Wang, Suzanne, Kosmider, Rachel, Wong, Jeremy, Shapiro, Margaret, Lee, Sam, Harris, Adnan, Khattak, Matthew, Burge, Marion, Harris, James, Lynam, Louise, Nott, Fiona, Day, Theresa, Hayes, Sue-Anne, McLachlan, Belinda, Lee, Janine, Ptak, Natalie, Silliman, Lisa, Dobbyn, Maria, Popoli, Ralph, Hruban, Anne Marie, Lennon, Nicholas, Papadopoulos, Kenneth W, Kinzler, Bert, Vogelstein, Cristian, Tomasetti, Peter, Gibbs, Susanne, Kosmider
Publikováno v:
New England Journal of Medicine. 386:2261-2272
The role of adjuvant chemotherapy in stage II colon cancer continues to be debated. The presence of circulating tumor DNA (ctDNA) after surgery predicts very poor recurrence-free survival, whereas its absence predicts a low risk of recurrence. The be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a73799f06b69d01e6f302d570bc06b
https://doi.org/10.1056/nejmoa2200075
https://doi.org/10.1056/nejmoa2200075