Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kenneth W, Foreman"'
Autor:
Bryan M. Delfing, Xavier E. Laracuente, Xingyu Luo, Audrey Olson, William Jeffries, Kenneth W. Foreman, Mikell Paige, Kylene Kehn-Hall, Christopher Lockhart, Dmitri K. Klimov
Publikováno v:
ACS Omega, Vol 9, Iss 38, Pp 40259-40268 (2024)
Externí odkaz:
https://doaj.org/article/fa808101ebc248e1b00e2437d38b4502
Autor:
Kyung Hyeon Lee, Nadia Fazal Ali, Soo Hyeon Lee, Zhimin Zhang, Marie Burdick, Zachary J. Beaulac, Greg Petruncio, Linxia Li, Jiangdong Xiang, Ezra M. Chung, Kenneth W. Foreman, Schroeder M. Noble, Yun M. Shim, Mikell Paige
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The aminopeptidase activity (AP) of the leukotriene A4 hydrolase (LTA4H) enzyme has emerged as a therapeutic target to modulate host immunity. Initial reports focused on the benefits of augmenting the LTA4H AP activity and clearing its putat
Externí odkaz:
https://doaj.org/article/5e035599853c418c91141324ae6d3acc
Autor:
Bryan M. Delfing, Audrey Olson, Xavier E. Laracuente, Kenneth W. Foreman, Mikell Paige, Kylene Kehn-Hall, Christopher Lockhart, Dmitri K. Klimov
Publikováno v:
The Journal of Physical Chemistry B. 127:3175-3186
Autor:
Kenneth W Foreman
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188134 (2017)
Empirical data has shown that bivalent inhibitors can bind a given target protein significantly better than their monomeric counterparts. However, predicting the corresponding theoretical fold improvements has been challenging. The current work build
Externí odkaz:
https://doaj.org/article/ae7c7eee96044232a17ea14e9b68359b
Autor:
Kyung Hyeon, Lee, Nadia Fazal, Ali, Soo Hyeon, Lee, Zhimin, Zhang, Marie, Burdick, Zachary J, Beaulac, Greg, Petruncio, Linxia, Li, Jiangdong, Xiang, Ezra M, Chung, Kenneth W, Foreman, Schroeder M, Noble, Yun M, Shim, Mikell, Paige
Publikováno v:
Scientific reports. 12(1)
The aminopeptidase activity (AP) of the leukotriene A
Autor:
Jutta Wanner, Darlene Romashko, Douglas S Werner, Earl W May, Yue Peng, Ryan Schulz, Kenneth W Foreman, Suzanne Russo, Lee D Arnold, Maneesh Pingle, Donald E Bergstrom, Francis Barany, Stuart Thomson
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121793 (2015)
We describe the successful application of a novel approach for generating dimeric Myc inhibitors by modifying and reversibly linking two previously described small molecules. We synthesized two directed libraries of monomers, each comprised of a liga
Externí odkaz:
https://doaj.org/article/a96fd43cf1cf4560b2de89acf1760b8b
Autor:
Sarah F. Giardina, Douglas S. Werner, Maneesh Pingle, Philip B. Feinberg, Kenneth W. Foreman, Donald E. Bergstrom, Lee D. Arnold, Francis Barany
Publikováno v:
Journal of medicinal chemistry. 63(6)
β-Tryptase, a homotetrameric serine protease, has four identical active sites facing a central pore, presenting an optimized setting for the rational design of bivalent inhibitors that bridge two adjacent sites. Using diol, hydroxymethyl phenols or
Autor:
Douglas S. Werner, Lee D. Arnold, Maneesh Pingle, Donald E. Bergstrom, Kenneth W. Foreman, Sarah F Giardina, Francis Barany
Publikováno v:
ACS Medicinal Chemistry Letters
Tryptase, a serine protease released from mast cells, is implicated in many allergic and inflammatory disorders. Human tryptase is a donut-shaped tetramer with the active sites facing inward forming a central pore. Bivalent ligands spanning two activ
Autor:
Kenneth W Foreman, Mark Brown, Frances Park, Spencer Emtage, June Harriss, Chhaya Das, Li Zhu, Andy Crew, Lee Arnold, Salam Shaaban, Philip Tucker
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22290 (2011)
The SET and MYND Domain (SMYD) proteins comprise a unique family of multi-domain SET histone methyltransferases that are implicated in human cancer progression. Here we report an analysis of the crystal structure of the full length human SMYD3 in a c
Externí odkaz:
https://doaj.org/article/8a5e03af3211429fbe1dc1ff4855df90
Autor:
Chhaya Das, Mark A. Brown, Melissa A. Edwards, Li Zhu, June V. Harriss, Haley O. Tucker, Kenneth W. Foreman, Salam Shaaban
Publikováno v:
Oncotarget
// Mark A. Brown 1, * , Kenneth Foreman 2, * , June Harriss 3 , Chhaya Das 3 , Li Zhu 3 , Melissa Edwards 1, 3 , Salam Shaaban 4 , Haley Tucker 3 1 Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA 2 Coferon Inc.