Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Kenneth Thummel"'
1
Akademický článek
Reversible, Time-Dependent Inhibition of CYP3A-Mediated Metabolism of Midazolam and Tacrolimus by Telaprevir in Human Liver Microsomes
Autor: Brian Chapron, Linda Risler, Brian Phillips, Carol Collins, Kenneth Thummel, Danny Shen
Publikováno v: Journal of Pharmacy & Pharmaceutical Sciences, Vol 18, Iss 1 (2015)
Purpose Telaprevir inhibits CYP3A resulting in drug-drug interactions (DDI) of unprecedented magnitude. We investigated the mechanisms by which telaprevir inhibits the oxidation of midazolam and tacrolimus in human liver microsomes (HLM). Methods We
Externí odkaz: https://doaj.org/article/4b803763d89948729ddf3edbd392cfe3
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2
Values and Practices to Strengthen Genetic Research Partnerships with Indigenous Communities
Autor: Wylie Burke, Julie A. Beans, Mildred K. Cho, Nanibaa’ A. Garrison, Vanessa Hiratsuka, Scarlett Hopkins, Paul G. Spicer, Krystal S. Tsosie, Erica L. Woodahl, Joseph M. Yracheta, Kenneth Thummel, null Participants in the Strengthening P
Publikováno v: Progress in Community Health Partnerships: Research, Education, and Action. 16:583-592
Genetic datasets lack diversity and include very few data from Indigenous populations. Research models based on equitable partnership have the potential to increase Indigenous participation and have led to successful collaborations. We report here on
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac912ca0ecee6b39755d44bbf5b9de0
https://doi.org/10.1353/cpr.2022.0079
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5
Investigation of the mechanistic basis of N,N-dimethylformamide toxicity. Metabolism of N,N-dimethylformamide and its deuterated isotopomers by cytochrome P450 2E1
Autor: Ruth Hyland, Michael D. Threadgill, Andreas Gescher, Kenneth Thummel, Parmjit Jheeta, Jaroslav Mráz
Publikováno v: Chemical Research in Toxicology. 6:197-207
Dimethylformamide (DMF) is an industrial solvent with hepatotoxic properties. The toxicity of DMF has been associated with its metabolism to S-(N-methylcarbamoyl)glutathione (SMG). The major urinary metabolite of DMF is N-(hydroxymethyl)-N-methylform
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453d4b2c09e7744507fb05b407be52bc
https://doi.org/10.1021/tx00032a009
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6
Human liver cytochrome P450 2D6 genotype, full-length messenger ribonucleic acid, and activity assessed with a novel cytochrome P450 2D6 substrate
Autor: Lisa, McConnachie, Miklos, Bodor, Kris, Kowdley, Adam, Levy, Bruce, Tung, Kenneth, Thummel, Brian, Phillips, Manoj, Bajpai, Victor, Chi, Joel D, Esmay, Danny D, Shen, Rodney J Y, Ho
Publikováno v: Clinical pharmacology and therapeutics. 75(4)
The goal of this study was to develop and validate a cytochrome P450 (CYP) 2D6 probe substrate with improved sensitivity to elucidate the relationship of CYP2D6 ribonucleic acid transcript levels, genotype, and enzyme activity in human liver biopsy s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc509154b1cc108273cb17823ce3c907
https://pubmed.ncbi.nlm.nih.gov/15060507
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7
Akademický článek
Responsible Research With Urban American Indians and Alaska Natives.
Autor: James RD; Rosalina D. James, Abigail EchoHawk, Adrian Dominguez, Leah Dodge, and Ralph Forquera are with the Urban Indian Health Institute, Seattle Indian Health Board, Seattle, WA. Kathleen M. West, Maile Taualii, and Wylie Burke are with the Department of Bioethics and Humanities, University of Washington, Seattle. Katrina G. Claw and Kenneth Thummel are with the Department of Pharmaceutics, University of Washington, Seattle., West KM; Rosalina D. James, Abigail EchoHawk, Adrian Dominguez, Leah Dodge, and Ralph Forquera are with the Urban Indian Health Institute, Seattle Indian Health Board, Seattle, WA. Kathleen M. West, Maile Taualii, and Wylie Burke are with the Department of Bioethics and Humanities, University of Washington, Seattle. Katrina G. Claw and Kenneth Thummel are with the Department of Pharmaceutics, University of Washington, Seattle., Claw KG; Rosalina D. James, Abigail EchoHawk, Adrian Dominguez, Leah Dodge, and Ralph Forquera are with the Urban Indian Health Institute, Seattle Indian Health Board, Seattle, WA. Kathleen M. West, Maile Taualii, and Wylie Burke are with the Department of Bioethics and Humanities, University of Washington, Seattle. Katrina G. Claw and Kenneth Thummel are with the Department of Pharmaceutics, University of Washington, Seattle., EchoHawk A; Rosalina D. James, Abigail EchoHawk, Adrian Dominguez, Leah Dodge, and Ralph Forquera are with the Urban Indian Health Institute, Seattle Indian Health Board, Seattle, WA. Kathleen M. West, Maile Taualii, and Wylie Burke are with the Department of Bioethics and Humanities, University of Washington, Seattle. Katrina G. Claw and Kenneth Thummel are with the Department of Pharmaceutics, University of Washington, Seattle., Dodge L; Rosalina D. James, Abigail EchoHawk, Adrian Dominguez, Leah Dodge, and Ralph Forquera are with the Urban Indian Health Institute, Seattle Indian Health Board, Seattle, WA. Kathleen M. West, Maile Taualii, and Wylie Burke are with the Department of Bioethics and Humanities, University of Washington, Seattle. Katrina G. Claw and Kenneth Thummel are with the Department of Pharmaceutics, University of Washington, Seattle., Dominguez A; Rosalina D. James, Abigail EchoHawk, Adrian Dominguez, Leah Dodge, and Ralph Forquera are with the Urban Indian Health Institute, Seattle Indian Health Board, Seattle, WA. Kathleen M. West, Maile Taualii, and Wylie Burke are with the Department of Bioethics and Humanities, University of Washington, Seattle. Katrina G. Claw and Kenneth Thummel are with the Department of Pharmaceutics, University of Washington, Seattle., Taualii M; Rosalina D. James, Abigail EchoHawk, Adrian Dominguez, Leah Dodge, and Ralph Forquera are with the Urban Indian Health Institute, Seattle Indian Health Board, Seattle, WA. Kathleen M. West, Maile Taualii, and Wylie Burke are with the Department of Bioethics and Humanities, University of Washington, Seattle. Katrina G. Claw and Kenneth Thummel are with the Department of Pharmaceutics, University of Washington, Seattle., Forquera R; Rosalina D. James, Abigail EchoHawk, Adrian Dominguez, Leah Dodge, and Ralph Forquera are with the Urban Indian Health Institute, Seattle Indian Health Board, Seattle, WA. Kathleen M. West, Maile Taualii, and Wylie Burke are with the Department of Bioethics and Humanities, University of Washington, Seattle. Katrina G. Claw and Kenneth Thummel are with the Department of Pharmaceutics, University of Washington, Seattle., Thummel K; Rosalina D. James, Abigail EchoHawk, Adrian Dominguez, Leah Dodge, and Ralph Forquera are with the Urban Indian Health Institute, Seattle Indian Health Board, Seattle, WA. Kathleen M. West, Maile Taualii, and Wylie Burke are with the Department of Bioethics and Humanities, University of Washington, Seattle. Katrina G. Claw and Kenneth Thummel are with the Department of Pharmaceutics, University of Washington, Seattle., Burke W; Rosalina D. James, Abigail EchoHawk, Adrian Dominguez, Leah Dodge, and Ralph Forquera are with the Urban Indian Health Institute, Seattle Indian Health Board, Seattle, WA. Kathleen M. West, Maile Taualii, and Wylie Burke are with the Department of Bioethics and Humanities, University of Washington, Seattle. Katrina G. Claw and Kenneth Thummel are with the Department of Pharmaceutics, University of Washington, Seattle.
Publikováno v: American journal of public health [Am J Public Health] 2018 Dec; Vol. 108 (12), pp. 1613-1616. Date of Electronic Publication: 2018 Oct 25.
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