Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kenneth T. Takeoka"'
Autor:
Mina Mostafavi, Lisha Wang, Lili Xie, Kenneth T. Takeoka, Daryl L. Richie, Fergal Casey, Alexey Ruzin, William S. Sawyer, Christopher M. Rath, Jun-Rong Wei, Charles R. Dean
Publikováno v:
mSphere, Vol 3, Iss 5 (2018)
ABSTRACT Tight coordination of inner and outer membrane biosynthesis is very important in Gram-negative bacteria. Biosynthesis of the lipid A moiety of lipopolysaccharide, which comprises the outer leaflet of the outer membrane has garnered interest
Externí odkaz:
https://doaj.org/article/1e5ff2b427e345449955f5246fb5ce69
Autor:
Jun-Rong Wei, Daryl L. Richie, Mina Mostafavi, Louis E. Metzger, Christopher M. Rath, William S. Sawyer, Kenneth T. Takeoka, Charles R. Dean
Publikováno v:
mSphere, Vol 2, Iss 4 (2017)
ABSTRACT Acinetobacter baumannii ATCC 19606 can grow without lipid A, the major component of lipooligosaccharide. However, we previously reported that depletion of LpxH (the fourth enzyme in the lipid A biosynthetic pathway) prevented growth of this
Externí odkaz:
https://doaj.org/article/e288e2e6824e4e1d854b8e90cdc75dee
Autor:
Colin K. Skepper, Robert J. Moreau, Brent A. Appleton, Bret M. Benton, Joseph E. Drumm, Brian Y. Feng, Mei Geng, Cheng Hu, Cindy Li, Andreas Lingel, Yipin Lu, Mulugeta Mamo, Wosenu Mergo, Mina Mostafavi, Christopher M. Rath, Micah Steffek, Kenneth T. Takeoka, Kyoko Uehara, Lisha Wang, Jun-Rong Wei, Lili Xie, Wenjian Xu, Qiong Zhang, Javier de Vicente
Publikováno v:
Journal of Medicinal Chemistry. 61:3325-3349
In the preceding manuscript [ Moreau et al. 2018 , 10.1021/acs.jmedchem.7b01691 ] we described a successful fragment-based lead discovery (FBLD) strategy for discovery of bacterial phosphopantetheine adenylyltransferase inhibitors (PPAT, CoaD). Follo
Autor:
Anke Blechschmidt, Brent A. Appleton, M. Geng, Jun-Rong Wei, J. de Vicente, Colin K. Skepper, Mika Lindvall, Bret Benton, Lili Xie, Brian Y. Feng, Carl J. Balibar, Qiong Zhang, Lisha Wang, Mulugeta Mamo, Valery Polyakov, Andreas Weiss, J.E. Drumm, Cindy Li, Wosenu Mergo, T.M. Smith, Kenneth T. Takeoka, Wenjian Xu, Kyoko Uehara, Yipin Lu, Robert J. Moreau, Andreas Lingel
Publikováno v:
Journal of Medicinal Chemistry. 61:3309-3324
The discovery and development of new antibiotics capable of curing infections due to multidrug-resistant and pandrug-resistant Gram-negative bacteria are a major challenge with fundamental importance to our global healthcare system. Part of our broad
Autor:
Alexey Ruzin, Fergal Casey, Lisha Wang, Charles R. Dean, William S. Sawyer, Kenneth T. Takeoka, Mina Mostafavi, Christopher M. Rath, Daryl L. Richie, Jun-Rong Wei, Lili Xie
Publikováno v:
mSphere, Vol 3, Iss 5 (2018)
Tight coordination of inner and outer membrane biosynthesis is very important in Gram-negative bacteria. Biosynthesis of the lipid A moiety of lipopolysaccharide, which comprises the outer leaflet of the outer membrane has garnered interest for Gram-
Autor:
Richard Colvin, Dita M. Rasper, Johanne Blais, Adriana K. Jones, Ramadevi Prathapam, Alexey Ruzin, Xiaoyu Shen, John Fuller, Anthony Casarez, Jun-Rong Wei, Sara Lopez, Alun Bermingham, Peter Skewes-Cox, Tsuyoshi Uehara, Pramila Tamrakar, David T. Barkan, Fergal Casey, Louis E. Metzger, Mina Mostafavi, Robert Lowell Simmons, Kenneth T. Takeoka, Charles R. Dean, Folkert Reck, Cindy Li, Jacob Shaul
The monobactam scaffold is attractive for the development of new agents to treat infections caused by drug-resistant Gram-negative bacteria because it is stable to metallo-β-lactamases (MBLs). However, the clinically used monobactam aztreonam lacks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b6aef2e61e0d9a42ba314a881df917
https://europepmc.org/articles/PMC6153799/
https://europepmc.org/articles/PMC6153799/
Autor:
Cindy Li, Mei Geng, Xiaoyu Shen, Joseph Drumm, Robert J. Moreau, Jun-Rong Wei, Colin K. Skepper, Bret Benton, Brian Y. Feng, Micah Steffek, Kenneth T. Takeoka, Lisha Wang, Christopher M. Rath, Wenjian Xu, Qiong Zhang, Javier de Vicente
Publikováno v:
ACS infectious diseases. 4(3)
Drug-resistant Gram-negative bacteria are of increasing concern worldwide. Novel antibiotics are needed, but their development is complicated by the requirement to simultaneously optimize molecules for target affinity and cellular potency, which can
Autor:
Angela L. Woods, Kenneth T. Takeoka, Charles R. Dean, Jun-Rong Wei, Ruth E. Caughlan, Adriana K. Jones, Xiaoyu Shen
Argyrins are natural products with antibacterial activity against Gram-negative pathogens, such as Pseudomonas aeruginosa , Burkholderia multivorans , and Stenotrophomonas maltophilia . We previously showed that argyrin B targets elongation factor G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d4fcec4170d625886054141b06f0df
https://europepmc.org/articles/PMC5365729/
https://europepmc.org/articles/PMC5365729/
Autor:
William S. Sawyer, Louis E. Metzger, Daryl L. Richie, Jade Bojkovic, Kenneth T. Takeoka, Christopher M. Rath, Charles R. Dean, Jun-Rong Wei
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 8, p e0160918 (2016)
PLoS ONE, Vol 11, Iss 8, p e0160918 (2016)
The lipid A moiety of lipopolysaccharide (LPS) is the main constituent of the outer leaflet of the Gram-negative bacterial outer membrane (OM) and is essential in many Gram-negative pathogens. An exception is Acinetobacter baumannii ATCC 19606, where
Autor:
Daryl L Richie, Kenneth T Takeoka, Jade Bojkovic, Louis E Metzger, Christopher M Rath, William S Sawyer, Jun-Rong Wei, Charles R Dean
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160918 (2016)
The lipid A moiety of lipopolysaccharide (LPS) is the main constituent of the outer leaflet of the Gram-negative bacterial outer membrane (OM) and is essential in many Gram-negative pathogens. An exception is Acinetobacter baumannii ATCC 19606, where
Externí odkaz:
https://doaj.org/article/ddda739d74a845db853b3b3ed0f64e8c