Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kenneth T. Locke"'
Autor:
Carrie Xu, George C. Morton, Vinayak Hosagrahara, Shung Wu, Denis E. Ryono, Jonathan Lippy, Narayanan Hariharan, Kenneth T. Locke, Xiang-Xang Ye, Wei Wang, Liqun Gu, Yi-Xin Li, Fucheng Qu, Peter T. W. Cheng, Sean S. Chen, Kevin O’Malley, Michael Cap, Robert Zahler, Tao Wang, Lori Kunselman, Charles Z. Ding, Cuixia Chu, Rebecca A. Smirk, Neil Flynn, Pratik Devasthale, Hao Zhang, Nathan Morgan, Atsu Apedo, Thomas Harrity, Lisa Zhang, Dennis Farrelly, Arthur M. Doweyko, Zhi Lai, Tim Herpin, Pathanjali Kadiyala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1196-1205
The design, synthesis and structure–activity relationships of a novel series of 3,4-disubstituted pyrrolidine acid analogs as PPAR ligands is outlined. In both the 1,3- and 1,4-oxybenzyl pyrrolidine acid series, the preferred stereochemistry was sh
Autor:
Lori Kunselman, Narayanan Hariharan, Pathanjali Kadiyala, Kenneth T. Locke, Denis E. Ryono, Thomas Harrity, Wei Wang, Arthur M. Doweyko, Randy Ponticiello, Liqun Gu, Pratik Devasthale, Lisa Zhang, Dennis Farrelly, Rachel Zebo, Michael Cap, Robert Zahler, Jodi K. Muckelbauer, Chiehying Chang, Cuixia Chu, Peter T. W. Cheng, Kevin O’Malley, Nathan Morgan, Litao Zhang, Jonathan Lippy, Vinayak Hosagrahara
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1939-1944
A novel class of azetidinone acid-derived dual PPARalpha/gamma agonists has been synthesized for the treatment of diabetes and dyslipidemia. The preferred stereochemistry in this series for binding and functional agonist activity against both PPARalp
Autor:
Jun Li, Lawrence J. Kennedy, Shung Wu, Carrie Xu, Hossain Monshizadegan, Stanley R. Krystek, Robert Zahler, Thomas Harrity, Huiping Zhang, Daniel Meyers, Debra Search, Yongmi An, Chiehying Chang, Rebecca A. Smirk, Michael Cap, Rongan Zhang, Shiwei Tao, Bang-Chi Chen, Ngiap-Kie Lim, Hao Zhang, Peter T. W. Cheng, Litao Zhang, Lori Kunselman, Stephanie Y. Chen, Pratik Devasthale, Pathanjali Kadiyala, Andres S. Hernandez, Michael A. Blanar, Joseph A. Tino, Ranjan Mukherjee, Ying Wang, Xiang-Yang Ye, Chen Sean, Yan Shi, Kevin O’Malley, Bowman Miao, Scott A. Bolton, Zhi Lai, Rai Ajit Srivastava, Wei Wang, Vinayak Hosagrahara, Kenneth T. Locke, Denis E. Ryono, Denise Grimm, Lisa Zhang, Jodi K. Muckelbauer, Yi-Xin Li
Publikováno v:
Journal of medicinal chemistry. 53(7)
An 1,3-oxybenzylglycine based compound 2 (BMS-687453) was discovered to be a potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist, with an EC(50) of 10 nM for human PPARalpha and approximately 410-fold selectivity vs h
Autor:
Denise Grimm, Lisa Zhang, Daniel Meyers, Peter T. W. Cheng, Raijit Srivastava, Yongmi An, Chiehying Chang, Jonathan Lippy, Debra Search, Jodi K. Muckelbauer, Kenneth T. Locke, Hossain Monshizadegan, Rongan Zhang, Xiang-Yang Ye, Celeste Twamley, Stephanie Y. Chen, T.-J. Yang, Litao Zhang, Joseph A. Tino, Vinayak Hosagrahara, Ranjan Mukherjee, Kevin O’Malley, Bowman Miao, Hao Zhang
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(9)
The synthesis and follow-up SAR studies of our development candidate 1 by incorporating 2-aryl-4-oxazolylmethoxy and 2-aryl-4-thiazolylmethoxy moieties into the oxybenzylglycine framework of the PPARalpha/gamma dual agonist muraglitazar is described.
Autor:
Aneka Bell, Lisa Zhang, Dennis Farrelly, Denis E. Ryono, Robert Zahler, Jodi K. Muckelbauer, Jonathan Lippy, Chiehying Chang, Cuixia Chu, Thomas Harrity, Carrie Xu, Narayanan Hariharan, Neil Flynn, Vinayak Hosagrahara, Wei Wang, Michael Cap, Lisa Moore, Pathanjali Kadiyala, Peter T. W. Cheng, Hao Zhang, Liqun Gu, Litao Zhang, Kevin O’Malley, Arthur M. Doweyko, Nathan Morgan, Pratik Devasthale, Kenneth T. Locke, Lori Kunselman
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(5)
The design, synthesis and structure–activity relationships of a novel series of N-phenyl-substituted pyrrole, 1,2-pyrazole and 1,2,3-triazole acid analogs as PPAR ligands are outlined. The triazole acid analogs 3f and 4f were identified as potent d
Autor:
Kenneth T. Locke, Jonathan Lippy, Dennis Farrelly, Neil Flynn, Narayanan Hariharan, Liqun Gu, Yi-Xin Li, Celeste Twamley, Robert Zahler, Xiang-Yang Ye, Kevin O’Malley, Litao Zhang, Denis E. Ryono, Peter T. W. Cheng
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(12)
Several series of substituted dehydropiperidine and piperidine-4-carboxylic acid analogs have been designed and synthesized as novel, potent dual PPARalpha/gamma agonists. The SAR of these series of analogs is discussed. A rare double bond migration