Acoustic separation in plastic microfluidics for rapid detection of bacteria in blood using engineered bacteriophage

Autor: P. Dow, Jason O. Fiering, Kenneth T. Kotz, Jason Holder, Sarah Gruszka

Publikováno v: Lab on a chip. 18(6)

A more effective treatment of bacteremia requires a diagnostic platform that is both sensitive, accurate and rapid. Currently, clinical laboratory techniques require growth of bacteria prior to diagnosis, take days to complete, and leave empiric ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb537e2a554fd6746ab2a1477b6bdc59
https://pubmed.ncbi.nlm.nih.gov/29445800

Feature issue introduction: biophotonic materials and applications

Autor: Kwang Sup Lee, Chantal Andraud, Konstanting Sokolov, Gang Zheng, Kaoru Tamada, Kenneth T. Kotz

Publikováno v: Optical Materials Express
Optical Materials Express, OSA pub, 2016, 6 (5), pp.1747-1750. ⟨10.1364/OME.6.001747⟩
Biomedical Optics Express
Optical Materials Express, 2016, 6 (5), pp.1747-1750. ⟨10.1364/OME.6.001747⟩

International audience; Biophotonics can be defined as the interplay of light and biological matter. The percolation of new optical technology into the realm of biology has literally shed new light into the inner workings of biological systems. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda9683d291409061cce3060caba46e7
https://hal.archives-ouvertes.fr/hal-01526226

Microfluidics-Based Capture of Human Neutrophils for Expression Analysis in Blood and Bronchoalveolar Lavage

Autor: Alex G. Cuenca, Ricardo Ungaro, Lyle L. Moldawer, Claudia Roberta de Castro Moreno, Larry Martin, Amer Abouhamze, Henry V. Baker, Ronald G. Tompkins, Kerri A. O’Malley, Kenneth T. Kotz, Kindra M. Kelly-Scumpia, Jennifer Lanz, M. Cecilia Lopez, Philip A. Efron, Elizabeth A. Warner, Mehmet Toner

Publikováno v: Laboratory investigation; a journal of technical methods and pathology

Gene expression analysis can be a powerful tool in predicting patient outcomes and identifying patients who may benefit from targeted therapies. However, isolating human blood polymorphonuclear cells (PMNs) for genomic analysis has been challenging.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b26a7564519757c8a0edf71a88d52fa
http://europepmc.org/articles/PMC3957199

Clinical microfluidics for neutrophil genomics and proteomics

Autor: David G. Camp, Wenzong Xiao, Kenneth T. Kotz, Ronald G. Tompkins, Carol L. Miller-Graziano, Brianne O. Petritis, Asit De, Daniel Irimia, Weihong Xu, Julie Wilhelmy, Wei-Jun Qian, Aman Russom, Jeremy Goverman, Michael N. Mindrinos, Shawn P. Fagan, Mehmet Toner, Bernard H. Brownstein, Richard D. Smith, Paul E. Bankey, Alan E. Rosenbach, Elizabeth A. Warner, Ronald W. Davis, Lyle L. Moldawer

Publikováno v: Nature medicine

Neutrophils play critical roles in modulating the immune response. We present a robust methodology for rapidly isolating neutrophils directly from whole blood and develop ‘on-chip’ processing for mRNA and protein isolation for genomics and proteo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f36f4b243f812c0c1ac5c8beaba771
https://doi.org/10.1038/nm.2205

Dynamics of Photosubstitution Reactions of Fe(CO)5: An Ultrafast Infrared Study of High Spin Reactivity

Autor: Sheryl D. Mebane, Christine K. Payne, Preston T. Snee, Kenneth T. Kotz, Charles B. Harris

Publikováno v: Journal of the American Chemical Society. 123:6909-6915

The photosubstitution reactions of Fe(CO)5 with alcohols and triethylphosphine have been studied in room temperature solution using femtosecond UV pump IR probe techniques. The dynamics of Fe(CO)5 in alcohols show that the coordination of the hydroxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cfb0813b7e8bec174d7d88edf5f4e92
https://doi.org/10.1021/ja010648r