Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Kenneth T. Bogen"'
Publikováno v:
Toxicology Reports, Vol 4, Iss , Pp 32-38 (2017)
The in vitro arsenite (AsIII) cytotoxicity dose-response (DR) of human keratinocytes (HEK001) was examined at greater statistical resolution than ever previously reported using the MTT assay to determine cell viability. Fifty-four 96-well plates were
Externí odkaz:
https://doaj.org/article/58ed06cac86c4980abfe2b4726875f45
Autor:
Kenneth T. Bogen
Publikováno v:
Dose-Response, Vol 17 (2019)
Linear-no-threshold (LNT) risk extrapolation has long been applied to estimate risks posed by low-level environmental carcinogen exposures, based on the 60-year-old multistage somatic mutation/clonal expansion (MSM) cancer theory. Recent evidence sup
Externí odkaz:
https://doaj.org/article/9ffed6ea78a94583a853a423b7a43fac
Autor:
Kenneth T. Bogen
Publikováno v:
Dose-Response, Vol 15 (2017)
Kelch-like ECH-associated protein 1 (Keap1), nuclear factor erythroid 2-like factor 2-related factor 2 (Nrf2), and the antioxidant response element (ARE) are interacting components of a master regulatory signaling pathway that coordinates redox homeo
Externí odkaz:
https://doaj.org/article/6c11d88d86ec479892dc37d2ae90aa52
Autor:
Kenneth T. Bogen
Publikováno v:
Dose-Response, Vol 12 (2014)
ED 001 -study data on increased liver and stomach tumor risks in >40,000 trout fed dibenzo[ a,l ]pyrene (DBP), one of the most potently mutagenic chemical carcinogens known, provide the greatest low-dose dose-response resolution of any experimentally
Externí odkaz:
https://doaj.org/article/d546feea31774184a30b6eedaab8ca90
Autor:
Kenneth T. Bogen
Publikováno v:
Dose-Response, Vol 9 (2011)
Benchmark Dose Model software (BMDS), developed by the U.S. Environmental Protection Agency, involves a growing suite of models and decision rules now widely applied to assess noncancer and cancer risk, yet its statistical performance has never been
Externí odkaz:
https://doaj.org/article/62251770af434ebe9986fbe92b90c0ca
Autor:
Louis Anthony Cox, Kenneth T. Bogen, Rory Conolly, Uschi Graham, Suresh Moolgavkar, Günter Oberdörster, Victor L. Roggli, Francesco Turci, Brooke Mossman
Publikováno v:
Environmental Research. 230:115607
Publikováno v:
Human and Ecological Risk Assessment: An International Journal. 27:2015-2037
Worker-specific Biological Exposure Action Levels (BEALs) for nickel (Ni) exposure are a urinary Ni concentration that reflects a dose that can be experienced on a daily basis without adverse syste...
Autor:
Kenneth T. Bogen
Publikováno v:
SSRN Electronic Journal.
Autor:
Melvin E. Andersen, Patrick D. McMullen, Kamala Kannan, Bryan Bals, S. Sathish Kumar, Bhavesh Dhirajlal Patel, Venkataraman Bringi, Neetha Paul, Rance Nault, Seetha Krishnan, James E. Klaunig, Nagesh Kuravadi, Lakshmanan Alagappan, Kenneth T. Bogen, K.C. Jayachandra, Timothy R. Zacharewski, B. Bhaskar Gollapudi, Farzaneh Teymouri, Michael B. Black
Publikováno v:
Toxicology and Applied Pharmacology
Acetamide (CAS 60-35-5) is detected in common foods. Chronic rodent bioassays led to its classification as a group 2B possible human carcinogen due to the induction of liver tumors in rats. We used a toxicogenomics approach in Wistar rats gavaged dai
Autor:
Kenneth T. Bogen
Publikováno v:
Nuclear Receptor Research, Vol 5, Pp 1-12 (2018)
Detailed dose-response data recently archived by the National Center for Biotechnology Information (NCBI) identified 853 human CAR (hCAR) agonists by quantitative high-throughput screening (qHTS) assays applied to >9,000 chemicals tested at ≥14 con