Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Kenneth T, MacLeod"'
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Reduced synchrony of calcium release and t-tubule structure organization in individual cardiomyocytes has been linked to loss of contractile strength and arrhythmia. Compared to confocal scanning techniques widely used for imaging calci
Externí odkaz:
https://doaj.org/article/05cfab0c358b490ab72c980a693ebdcb
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Background: The increased risk of post-menopausal women developing abnormalities of heart function emphasises the requirement to understand the effect of declining oestrogen levels on cardiac electrophysiology and structure, and investigate possible
Externí odkaz:
https://doaj.org/article/11d4aaa2e9674035aa8c18bdb6de14a3
Autor:
Brian X. Wang, Christopher Kane, Laura Nicastro, Oisín King, Worrapong Kit-Anan, Barrett Downing, Graziano Deidda, Liam S. Couch, Christian Pinali, Anna Mitraki, Kenneth T. MacLeod, Cesare M. Terracciano
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10940 (2022)
Engagement of the sarcoplasmic reticulum (SR) Ca2+ stores for excitation–contraction (EC)-coupling is a fundamental feature of cardiac muscle cells. Extracellular matrix (ECM) proteins that form the extracellular scaffolding supporting cardiac cont
Externí odkaz:
https://doaj.org/article/a0c335a772f34dd3b77998664e203c38
Autor:
Brian X. Wang, Laura Nicastro, Liam Couch, Worrapong Kit-Anan, Barrett Downing, Kenneth T. MacLeod, Cesare M. Terracciano
Publikováno v:
Cells, Vol 11, Iss 7, p 1171 (2022)
Cardiac fibroblasts regulate the development of the adult cardiomyocyte phenotype and cardiac remodeling in disease. We investigate the role that cardiac fibroblasts-secreted extracellular vesicles (EVs) have in the modulation of cardiomyocyte Ca2+ c
Externí odkaz:
https://doaj.org/article/31937fd2fba040a6b252d09d12125a8a
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The measurement of the contractile behavior of single cardiomyocytes has made a significant contribution to our understanding of the physiology and pathophysiology of the myocardium. However, the isolation of cardiomyocytes introduces various technic
Externí odkaz:
https://doaj.org/article/58901f24326143c080cf67d9ff4e7539
Autor:
Kenneth T. MacLeod
Publikováno v:
The Journal of Physiology. 601:905-921
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5ab28c2159f8072011e4f2c46c61845
https://doi.org/10.1113/jp283082
https://doi.org/10.1113/jp283082
Autor:
H. Surendran, Alice J. Francis, Jahn M. Firth, T. P. Collins, H.‐Y. Ke, Hsiang-Yu Yang, Anita Alvarez-Laviada, Kenneth T. MacLeod
Publikováno v:
The Journal of Physiology
Key points During compensated hypertrophy in vivo fractional shortening (FS) remains constant until heart failure (HF) develops, when FS decreases from 70% to 39%.Compensated hypertrophy is accompanied by an increase in I Na,late and a decrease in Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c31879d079135842e604cc28412055
https://doi.org/10.1113/jp277038
https://doi.org/10.1113/jp277038
Flecainide is used to treat catecholaminergic polymorphic ventricular tachycardia (CPVT), an arrhythmia caused by disrupted cellular Ca2+ handling following β-adrenergic stimulation. The clinical efficacy of flecainide in this context involves compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01e27c8dfc24c8d53a2a1416b24ecc0
https://cronfa.swan.ac.uk/Record/cronfa58568
https://cronfa.swan.ac.uk/Record/cronfa58568
Publikováno v:
European Heart Journal. 42
Background Post-menopausal women have an enhanced risk of developing cardiovascular disease and disturbances of cardiac rhythm, generally attributed to declining oestrogen levels during menopause. In an animal model that mimics menopause, the long-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dec2093abda5429d6556cf9f6cfca9a7
https://doi.org/10.1093/eurheartj/ehab724.3208
https://doi.org/10.1093/eurheartj/ehab724.3208
Autor:
Priyanthi Dias, Thomas Desplantez, Majd A El-Harasis, Rasheda A Chowdhury, Nina D Ullrich, Alberto Cabestrero de Diego, Nicholas S Peters, Nicholas J Severs, Kenneth T MacLeod, Emmanuel Dupont
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90266 (2014)
The HL-1 atrial line contains cells blocked at various developmental stages. To obtain homogeneous sub-clones and correlate changes in gene expression with functional alterations, individual clones were obtained and characterised for parameters invol
Externí odkaz:
https://doaj.org/article/9aec14f609514ce7a01cc28c9ee5b472