Self-assembly of heterobimetallic d-f hybrid complexes: sensitization of lanthanide luminescence by d-block metal-to-ligand charge-transfer excited states

Autor: Simon J. A. Pope, Xuan Yu, Benjamin J. Coe, Kenneth T. Douglas, Elena V. Bichenkova, Stephen Faulkner

Carboxylate-bearing d-transition metal bipyridyls form ternary complexes with seven-coordinate lanthanide centers. The neodymium,- ytterbium-, and erbium-containing complexes exhibit lanthanide-centered emissions sensitized by the MLCT states of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b341d1481a1b99d06a658618c6a94cc
https://doi.org/10.1021/ja047523h

Incorporation of Basic Side Chains into Cryptolepine Scaffold: Structure−Antimalarial Activity Relationships and Mechanistic Studies

Autor: Daniel J. V. A. dos Santos, Philip J. Rosenthal, Kenneth T. Douglas, Alexandra Paulo, João Lavrado, Rui Moreira, Jiri Gut, Ghislain G. Cabal, Maria M. Mota, Elena V. Bichenkova, Rita C. Guedes, Cecilia Díaz, Miguel Prudêncio

Publikováno v: Journal of Medicinal Chemistry. 54:734-750

The synthesis of cryptolepine derivatives containing basic side-chains at the C-11 position and their evaluations for antiplasmodial and cytotoxicity properties are reported. Propyl, butyl, and cycloalkyl diamine side chains significantly increased a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f01f689ba28437d12fdcdfbcf1b0e8
https://doi.org/10.1021/jm101383f

Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

Autor: Alberto C.C. Frasch, Michael H. Charlton, Paul N. Mortenson, Richard A. Bryce, Horacio Botti, Mark L. Brewer, Pedro M. Alzari, Alejandro Buschiazzo, João Neres, Kenneth T. Douglas, Laura Ratier, Philip Neil Edwards

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2009, 19 (3), pp.589-596. ⟨10.1016/j.bmcl.2008.12.065⟩
Bioorganic and Medicinal Chemistry Letters, 2009, 19 (3), pp.589-596. ⟨10.1016/j.bmcl.2008.12.065⟩

International audience; trans-Sialidase from Trypanosoma cruzi (TcTS) has emerged as a potential drug target for treatment of Chagas disease. Here, we report the results of virtual screening for the discovery of novel TcTS inhibitors, which targeted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d3df2ee80c2f17123994ec9e40de52
https://doi.org/10.1016/j.bmcl.2008.12.065

Molecular probes: insights into design and analysis from computational and physical chemistry

Autor: Richard A. Bryce, Gabriel E. Marks, Elena V. Bichenkova, Felicity L. Mitchell, Kenneth T. Douglas

Publikováno v: Biochemical Society Transactions. 36:46-50

The application of new molecular diagnostics to probe cellular process in vivo is leading to a greater understanding of molecular cytology at a sub-nanoscale level and is opening the way to individualized medicines. We review here three distinct fluo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3db20833136d0b1710181ce204a500b
https://doi.org/10.1042/bst0360046

Molecular Basis of Action of HyBeacon™ Fluorogenic Probes: A Spectroscopic and Molecular Dynamics Study

Autor: Kenneth T. Douglas, David John French, Elena V. Bichenkova, David Gordon Mcdowell, Pranab K. Bhadra, Abigail H. R. Marks, Richard A. Bryce

Publikováno v: Journal of Biomolecular Structure and Dynamics. 23:49-62

HyBeacons, novel DNA probes for ultra-rapid detection of single nucleotide polymorphisms, contain a fluorophore covalently attached via a linker group to an internal nucleotide. As the probe does not require a quencher or self-complementarity to func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995b17efdbed9452cb0e2e1e0a83b997
https://doi.org/10.1080/07391102.2005.10507046