Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Kenneth Steadman"'
Autor:
Kenneth Steadman, Sungyong You, Dustin V. Srinivas, Lila Mouakkad, Yiwu Yan, Minhyung Kim, Smrruthi V. Venugopal, Hisashi Tanaka, Michael R. Freeman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
The transcription factor ONECUT2 (OC2) is a master transcriptional regulator operating in metastatic castration-resistant prostate cancer that suppresses androgen receptor activity and promotes neural differentiation and tumor cell survival. OC2 mRNA
Externí odkaz:
https://doaj.org/article/b03a05dc336141cc9269afbf3a4d4378
Autor:
Michael R. Freeman, Dolores Di Vizio, Andries Zijlstra, Edwin M. Posadas, Amy C. Rowat, Hsian-Rong Tseng, Beatrice S. Knudsen, Wei Yang, Hisashi Tanaka, Leland W.K. Chung, Chia-Yi Chu, Mirja Rotinen, Adel Eskaros, Navjot Kaur Gill, Kenneth Steadman, Samantha Morley, Sungyong You, Tatiana Novitskaya, Jie-Fu Chen, Mariana Reis-Sobreiro
Nuclear membrane blebbing in amoeboid cells. Time-lapse analysis of DU145 DIAPH3-depleted cells treated with EGF and IL6 (exacerbates amoeboid features (13)) and stained with lipid fluorescent dye CellMask Orange.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5257dc55471006509cbe22b926a1dfd3
https://doi.org/10.1158/0008-5472.22420458
https://doi.org/10.1158/0008-5472.22420458
Autor:
Michael R. Freeman, Dolores Di Vizio, Andries Zijlstra, Edwin M. Posadas, Amy C. Rowat, Hsian-Rong Tseng, Beatrice S. Knudsen, Wei Yang, Hisashi Tanaka, Leland W.K. Chung, Chia-Yi Chu, Mirja Rotinen, Adel Eskaros, Navjot Kaur Gill, Kenneth Steadman, Samantha Morley, Sungyong You, Tatiana Novitskaya, Jie-Fu Chen, Mariana Reis-Sobreiro
Abnormalities in nuclear shape are a well-known feature of cancer, but their contribution to malignant progression remains poorly understood. Here, we show that depletion of the cytoskeletal regulator, Diaphanous-related formin 3 (DIAPH3), or the nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::967bf317983074748296f16fb44f9c2c
https://doi.org/10.1158/0008-5472.c.6510651.v1
https://doi.org/10.1158/0008-5472.c.6510651.v1
Autor:
Michael R. Freeman, Dolores Di Vizio, Andries Zijlstra, Edwin M. Posadas, Amy C. Rowat, Hsian-Rong Tseng, Beatrice S. Knudsen, Wei Yang, Hisashi Tanaka, Leland W.K. Chung, Chia-Yi Chu, Mirja Rotinen, Adel Eskaros, Navjot Kaur Gill, Kenneth Steadman, Samantha Morley, Sungyong You, Tatiana Novitskaya, Jie-Fu Chen, Mariana Reis-Sobreiro
Emerin deregulation links nuclear shape instability to metastatic potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41e2de4fe316a6c1f79fd7946e9fdb21
https://doi.org/10.1158/0008-5472.22420452
https://doi.org/10.1158/0008-5472.22420452
Autor:
Michael R. Freeman, Dolores Di Vizio, Andries Zijlstra, Edwin M. Posadas, Amy C. Rowat, Hsian-Rong Tseng, Beatrice S. Knudsen, Wei Yang, Hisashi Tanaka, Leland W.K. Chung, Chia-Yi Chu, Mirja Rotinen, Adel Eskaros, Navjot Kaur Gill, Kenneth Steadman, Samantha Morley, Sungyong You, Tatiana Novitskaya, Jie-Fu Chen, Mariana Reis-Sobreiro
Emerin deregulation links nuclear shape instability to metastatic potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83776de608fdbd98d41dd3ac267b55ee
https://doi.org/10.1158/0008-5472.22420449.v1
https://doi.org/10.1158/0008-5472.22420449.v1
Autor:
Kenneth Steadman, Gregory S. Parker, Geoffray Leriche, Sarah Fish, Julia Toth, Mary E. Spalding, Elizabeth Daniele, Aleksandar Jamborcic, Xiaoming Li, E Adam Kallel, Farhana Barmare, Kenneth Chng, Erika Green, Michael Hocker, Elliot Imler, Yi Zhang, Peggy A. Thompson, Simon Bailey
Publikováno v:
Cancer Research. 82:421-421
Prostate cancer is the second most common cause of cancer related deaths in men in the United States. Pathogenesis is driven by the androgen receptor (AR), which has led to front-line treatment modalities that are based on androgen deprivation therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89979bbcc05eda7e0c41ec9a438709f5
https://doi.org/10.1158/1538-7445.am2022-421
https://doi.org/10.1158/1538-7445.am2022-421
ONECUT2 is a Targetable Master Regulator of Lethal Prostate Cancer that Suppresses the Androgen Axis
Autor:
Michael R. Freeman, Dolores Di Vizio, Kenneth Steadman, Alberto Yáñez, Eva Corey, Colm Morrissey, Wen-Chin Huang, Stephen J. Freedland, Simon G. Coetzee, Dennis J. Hazelett, Fangjin Huang, Mariana Reis-Sobreiro, Ramachandran Murali, Sungyong You, Peter S. Nelson, Beatrice S. Knudsen, Chia-Yi Chu, Leland W.K. Chung, Xinlei Pan, Julie Yang, Isla P. Garraway, Mirja Rotinen
Publikováno v:
Nature medicine, vol 24, iss 12
Treatment of prostate cancer (PC) by androgen suppression promotes the emergence of aggressive variants that are androgen receptor- (AR-) independent. Here we identify the transcription factor ONECUT2 (OC2) as a master regulator of AR networks in met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27158e70c9d6ff1696dfeadfa9cb486f
https://europepmc.org/articles/PMC6614557/
https://europepmc.org/articles/PMC6614557/
Autor:
Tatiana Novitskaya, Edwin M. Posadas, Andries Zijlstra, Navjot Kaur Gill, Michael R. Freeman, Samantha Morley, Adel Eskaros, Amy C. Rowat, Chia-Yi Chu, Wei Yang, Leland W.K. Chung, Mirja Rotinen, Kenneth Steadman, Hisashi Tanaka, Hsian-Rong Tseng, Mariana Reis-Sobreiro, Dolores Di Vizio, Jie-Fu Chen, Sungyong You, Beatrice S. Knudsen
Publikováno v:
Cancer research. 78(21)
Abnormalities in nuclear shape are a well-known feature of cancer, but their contribution to malignant progression remains poorly understood. Here, we show that depletion of the cytoskeletal regulator, Diaphanous-related formin 3 (DIAPH3), or the nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505993d8f2ce436c0dc20163546f6fe8
https://pubmed.ncbi.nlm.nih.gov/30154147
https://pubmed.ncbi.nlm.nih.gov/30154147
Autor:
John L. Marshall, Yiru Wang, Christina E. Urso, John F. Deeken, Hongkun Wang, Jimmy J. Hwang, Corinne Ramos, Kenneth Steadman, Michael J. Pishvaian, Aiwu Ruth He, Deepa S. Subramaniam
Publikováno v:
Cancer. 121:1645-1653
BACKGROUND Acquired resistance to antiepidermal growth factor receptor (anti-EGFR) therapy may be caused by EGFR–v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ErbB2) heterodimerization and pathway reactivation. In preclinical stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5034f2b4dd20057d2aeac2a5b09b74f
https://doi.org/10.1002/cncr.29224
https://doi.org/10.1002/cncr.29224
Autor:
Martin H. Hager, Jiyoung Choi, Dolores Di Vizio, Rosalyn M. Adam, Wei Yang, Sungyong You, Sara Pollan, Jayoung Kim, Kavitha Rajendran, Kenneth Steadman, Cristiana Spinelli, Arkadiusz Gertych, Samantha Morley, Ramaswamy Krishnan, Michael R. Freeman, Beatrice S. Knudsen, Bo Zhou
Publikováno v:
Scientific Reports
Taxanes are widely employed chemotherapies for patients with metastatic prostate and breast cancer. Here, we show that loss of Diaphanous-related formin-3 (DIAPH3), frequently associated with metastatic breast and prostate cancers, correlates with in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b744171a1524f46f8f768ae3fc8bd89
http://europepmc.org/articles/PMC4503992
http://europepmc.org/articles/PMC4503992