Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kenneth Stauderman"'
Autor:
Marilena Letizia, Yin‐Hu Wang, Ulrike Kaufmann, Lorenz Gerbeth, Annegret Sand, Max Brunkhorst, Patrick Weidner, Jörn Felix Ziegler, Chotima Böttcher, Stephan Schlickeiser, Camila Fernández, Megumi Yamashita, Kenneth Stauderman, Katherine Sun, Désirée Kunkel, Murali Prakriya, IBDome Researchers, Ashley Sanders, Britta Siegmund, Stefan Feske, Carl Weidinger
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 9, Pp 1-25 (2022)
Abstract Inflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune responses. Using mass cytometry (CyTOF) to analyze the immune cell composition in the lamina propria (LP) of patients with ulcerative colitis (UC) and Crohn'
Externí odkaz:
https://doaj.org/article/997a99d779c54eab8e997f08e05290f9
Autor:
Charles Bruen, Mukhtar Al-Saadi, Edward A. Michelson, Maged Tanios, Raul Mendoza-Ayala, Joseph Miller, Jeffrey Zhang, Kenneth Stauderman, Sudarshan Hebbar, Peter C. Hou
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-11 (2022)
Abstract Background Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia. Methods CARDEA was a phase 2, ra
Externí odkaz:
https://doaj.org/article/5e65839213ba4503be60065eb8a8192f
Autor:
Joseph Miller, Charles Bruen, Michael Schnaus, Jeffrey Zhang, Sadia Ali, April Lind, Zachary Stoecker, Kenneth Stauderman, Sudarshan Hebbar
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-9 (2020)
Abstract Background Calcium release-activated calcium (CRAC) channel inhibitors stabilize the pulmonary endothelium and block proinflammatory cytokine release, potentially mitigating respiratory complications observed in patients with COVID-19. This
Externí odkaz:
https://doaj.org/article/b98ee325e8b3474dab0f76d9c03d1371
Autor:
Yin-Hu Wang, Lucile Noyer, Sascha Kahlfuss, Dimitrius Raphael, Anthony Y. Tao, Ulrike Kaufmann, Jingjie Zhu, Marisa Mitchell-Flack, Ikjot Sidhu, Fang Zhou, Martin Vaeth, Paul G. Thomas, Sean P. Saunders, Kenneth Stauderman, Maria A. Curotto de Lafaille, Stefan Feske
Publikováno v:
Science Advances. 8
T cell activation and function depend on Ca2+signals mediated by store-operated Ca2+entry (SOCE) through Ca2+release–activated Ca2+(CRAC) channels formed by ORAI1 proteins. We here investigated how SOCE controls T cell function in pulmonary inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97f41a300cd2068b074b4e31d37468a
https://doi.org/10.1126/sciadv.abn6552
https://doi.org/10.1126/sciadv.abn6552
Autor:
Charles Bruen, Mukhtar Al-Saadi, Edward Michelson, Maged Tanios, Raul Mendoza-Ayala, Joseph Miller, Jeffrey Zhang, Kenneth Stauderman, Sudarshan Hebbar, Peter Hou
Background: Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia. Methods: CARDEA was a phase 2, randomize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d5440423f01eead66aa5ce73aed56e9
https://doi.org/10.21203/rs.3.rs-1239555/v1
https://doi.org/10.21203/rs.3.rs-1239555/v1
Autor:
Camila Fernández-Zapata, Britta Siegmund, Max Brunkhorst, Marilena Letizia, Stephan Schlickeiser, Stefan Feske, Ulrike Kaufmann, Carl Weidinger, IBDome researchers, Annegret Sand, Chotima Böttcher, Yin Hu Wang, Kenneth Stauderman, Jörn F. Ziegler, Lorenz Gerbeth, Désirée Kunkel
ObjectiveInflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune responses and constitutes a major clinical challenge in need of new treatment modalities to improve patient care. Store-operated Ca2+ entry (SOCE) is the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b40f1277582899f4f96a491768c8a67
https://doi.org/10.1101/2021.09.11.21263401
https://doi.org/10.1101/2021.09.11.21263401
Autor:
Stephanie Ramos, Lori Butler, Trevor Kimbler, Jianguo Cao, Jonathan Grey, Evan Rogers, Zhijun Wang, Jeffrey Whitten, Jack Roos, Kenneth Stauderman, Gonul Velicelebi
Publikováno v:
The Journal of Immunology. 190:212.5-212.5
Engagement of the T cell receptor (TCR) triggers complex signaling cascades that result in various effector T cell responses. A critical component of TCR signaling is store-operated calcium entry (SOCE) that occurs through the activation of calcium r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92e8646f84a3fae659d1f076d8607f92
https://doi.org/10.4049/jimmunol.190.supp.212.5
https://doi.org/10.4049/jimmunol.190.supp.212.5
Autor:
Stephanie Ramos, Sergey Grigoryev, Evan Rogers, Jack Roos, Jeffrey Whitten, Kenneth Stauderman, Gonul Velicelebi
Publikováno v:
The Journal of Immunology. 188:72.3-72.3
Calcium-release activated calcium (CRAC) channel inhibitors represent a new class of oral immunomodulatory agents with a potential safety profile suitable for chronic dosing to treat autoimmune disorders. Calcium entry through CRAC channels is a crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::113a8002a5bf1a6c01dc7c413bbc59ab
https://doi.org/10.4049/jimmunol.188.supp.72.3
https://doi.org/10.4049/jimmunol.188.supp.72.3