Výsledky vyhledávání - "Kenneth Schooley"

Regulation of nuclear translocation of nuclear factor-kappaB relA: evidence for complex dynamics at the single-cell level

Autor: Eva E. Qwarnstrom, Steven K. Dower, Ping Zhu, Kenneth Schooley

Publikováno v: Biochemical Journal. 369:331-339

We have analysed activation of nuclear factor-kappaB (NF-kappaB) in response to interleukin-1 (IL-1) in human fibroblasts by tracking intracellular distribution and levels of endogenous relA, NF-kappaB1 and inhibitor of kappaB (I-kappaB) alpha using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550187dad22e8863c93ebaff76417d2a
https://doi.org/10.1042/bj20020253

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UL16-Binding Proteins, Novel MHC Class I-Related Proteins, Bind to NKG2D and Activate Multiple Signaling Pathways in Primary NK Cells

Autor: N. Jan Chalupny, Marek Kubin, Claire L. Sutherland, Tim VandenBos, Kenneth Schooley, David Cosman

Publikováno v: The Journal of Immunology. 168:671-679

The UL16-binding proteins (ULBPs) are a novel family of MHC class I-related molecules that were identified as targets of the human CMV glycoprotein, UL16. We have previously shown that ULBP expression renders a relatively resistant target cell sensit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3460f9596cfaacb11830ba0608bd99e7
https://doi.org/10.4049/jimmunol.168.2.671

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Identification of Two Major Sites in the Type I Interleukin-1 Receptor Cytoplasmic Region Responsible for Coupling to Pro-inflammatory Signaling Pathways

Autor: Timothy P. Bonnert, Jennifer L. Mitcham, Kenneth Schooley, Jennifer L. Slack, Eva E. Qwarnstrom, Steven K. Dower, John E. Sims

Publikováno v: Journal of Biological Chemistry. 275:4670-4678

Type I interleukin-1 receptor is the prototype for a family of proteins, which play a central role in early responses to injury and infection. The similarity of function across the family is reflected in similarity in signaling: all members tested co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1d8760019aab5f8f4abff43db242fb
https://doi.org/10.1074/jbc.275.7.4670

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Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit

Autor: G. Duke Virca, Steven K. Dower, Kenneth Schooley, Heidi Hagen, Timothy A. Bird

Publikováno v: The Journal of biological chemistry. 272(51)

In fibroblasts and hepatoma cells, interleukin-1 (IL-1) treatment results in the rapid nuclear accumulation of the transcription factor NF-kappaB, present largely as p65 (RelA)/p50 heterodimers. It is well established that this process is dependent i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99e74e2199bf25fb324de8b714bdb40
https://pubmed.ncbi.nlm.nih.gov/9405476

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