Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Kenneth S. Rehder"'
1
Synthesis of [3 H] and [14 C]genipin
Autor: Scott P. Runyon, Adele.E. Queen, Desong Zhong, David Hesk, David M. Lindsay, William J. Kerr, Timothy R. Fennell, Wayne Mascarella, Kenneth S. Rehder
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 63:196-202
[3 H]Genipin was synthesized in a single step by Ir(I) catalyzed hydrogen isotope exchange. Conditions for selective exchange of the sp2 CH bond ortho to the methyl ester functionality were developed through deuterium modeling studies through a catal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0283f6e7cf473fa399212c4113fd94
https://doi.org/10.1002/jlcr.3832
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2
Synthesis of Carnosine-d7and Anserine-d4for Use as Internal Standards in Liquid Chromatography–Mass Spectrometry
Autor: Madathil B. Gopinathan, Chunyang Jin, Kenneth S. Rehder
Publikováno v: Synthetic Communications. 39:3973-3981
A convenient synthesis of carnosine-d7 and anserine-d4 is described. Coupling of N-Boc-β-alanine-d4 with L-histidine-d3 or 1-methyl-L-histidine using isobutyl chloroformate afforded the corresponding Boc-protected dipeptide. Subsequent Boc group dep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e930f94e590df6e1171a7e5542c53b5
https://doi.org/10.1080/00397910902838987
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3
A Short and Efficient Synthesis of 3-{2-[2-(Bromomethyl)thiazol-4-yl]-ethynyl}-5-fluorobenzonitrile: A Precursor for PET Radioligand [18F]SP203
Autor: Kenneth S. Rehder, Chunyang Jin, Madathil B. Gopinathan
Publikováno v: Synthesis. 2009:1979-1982
An improved synthesis of 3-{2-[2-(bromomethyl)thiazol-4-yl]ethynyl}-5-fluorobenzonitrile, a precursor for PET radioligand [ 18 F]SP203, is described, wherein a new synthon was employed for Sonogashira coupling with 3-bromo-5-fluorobenzonitrile. The n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::861c5551224f52266580bad64340c714
https://doi.org/10.1055/s-0029-1216787
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4
Practical Synthesis ofp‐Aminophenethylspiperone (NAPS), a High‐Affinity, Selective D2‐Dopamine Receptor Antagonist
Autor: George A. Brine, Anita H. Lewin, Kenneth S. Rehder, Louise D. Mayer, Chunyang Jin
Publikováno v: Synthetic Communications. 38:816-823
Because attempts to scale up the published synthetic preparation of p‐aminophenethylspiperone (NAPS) by N‐alkylation of spiperone with 4‐nitrophenethyl bromide followed by reduction gave poor yields and difficulties during purification, an alte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f867144f314910e301bf9805cc65dc76
https://doi.org/10.1080/00397910701821135
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5
Convenient Synthesis of Tolcapone, a Selective Catechol‐O‐methyltransferase Inhibitor
Autor: Kenneth S. Rehder, Chunyang Jin, Govindarajan Manikumar
Publikováno v: Synthetic Communications. 38:810-815
A convenient and efficient synthesis of tolcapone from commercial 4‐benzyloxy‐3‐methoxybenzaldehyde is presented. Grignard reaction of 4‐benzyloxy‐3‐methoxybenzaldehyde (1) with p‐tolylmagnesium bromide followed by Oppenauer oxidation o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60a56b718eeb6bcab4e1154c182a8244
https://doi.org/10.1080/00397910701821077
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6
Design, Synthesis, and Estrogenic Activity of a Novel Estrogen Receptor ModulatorA Hybrid Structure of 17β-Estradiol and Vitamin E in Hippocampal Neurons
Autor: Kenneth S. Rehder, Roberta Diaz Brinton, Madathil B. Gopinathan, Zisu Mao, Chunyang Jin, Liqin Zhao
Publikováno v: Journal of Medicinal Chemistry. 50:4471-4481
We recently discovered that ICI 182,780 (1), an antagonist of estrogen receptor (ER)-dependent proliferation in reproductive tissues, functions as an estrogenic agonist in primary neurons. The present study investigated whether the agonist properties
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90a41af6396ad20d47a83d15209f73d
https://doi.org/10.1021/jm070546x
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7
Improved Syntheses of N‐Desmethylcitalopram and N,N‐Didesmethylcitalopram
Autor: George A. Brine, Chunyang Jin, Kenneth S. Rehder, Karl G. Boldt
Publikováno v: Synthetic Communications. 37:901-908
An improved and efficient synthesis of N‐desmethylcitalopram (2) and N,N‐didesmethylcitalopram (3) is presented. The method involved N‐demethylation of citalopram (1) using 1‐chloroethyl chloroformate to give 2 in 87% yield. Synthesis of 3 wa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d207f71fa5cd2bc245213d77cf3a8812
https://doi.org/10.1080/00397910601163745
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8
An Improved Synthesis of (4-{4-Hydroxy-3-isopropyl-5-[(4-nitrophenyl)ethynyl]benzyl}-3,5-dimethylphenoxy)acetic Acid (NH-3)
Autor: Madathil B. Gopinathan, Kenneth S. Rehder
Publikováno v: Synthesis. 2009:1428-1430
Sonogashira coupling of methyl {4-[3-iodo-5-isopropyl-4-(methoxymethoxy)benzyl]-3,5-dimethylphenoxy}acetate with (trimethylsilyl)acetylene afforded the corresponding (trimethylsilyl)ethynyl derivative in quantitative yield. Copper-free palladium-cata
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76eb829bdfa1e513590aa90f678d2765
https://doi.org/10.1055/s-0028-1088041
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