Výsledky vyhledávání - "Kenneth S. Kilgore"

Use of a portable thermal imaging unit as a rapid, quantitative method of evaluating inflammation and experimental arthritis

Autor: Susan E. Bove, Brian Sanchez, Kenneth S. Kilgore, Melissa Thiel, David Brammer, Mark E. Lesch

Publikováno v: Journal of Pharmacological and Toxicological Methods. 57:169-175

Introduction Thermal imaging has been utilized, both preclinically and clinically, as a tool for assessing inflammation and arthritis. However, previous studies have employed large, relatively immobile devises to obtain the thermal signature of the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ff38707940e5c639c50753c5806d1b
https://doi.org/10.1016/j.vascn.2008.01.003

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Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists

Autor: Jack J. Kinsora, Jared B.J. Milbank, Rachel M. Brooker, Christopher S. Knauer, Kenneth S. Kilgore, Cleo J. C. Connolly, John A. Wendt, Corinne E. Augelli-Szafran, Koji Yamagata, Susan E. Bove, Mickelson John, Paul Galatsis, Roy D. Schwarz

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 17:6525-6528

We describe three novel regioisomeric series of aryl naphthyridine analogs, which are potent antagonists of the Class III GPCR mGlu5 receptor. The synthesis and in vitro and in vivo pharmacological activities of these analogs are discussed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99bb1ead705ce7ec70a6e5c13920183
https://doi.org/10.1016/j.bmcl.2007.09.083

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N-(6,7-Dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-d-aspartate receptor antagonists for the treatment of pain

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 17:4599-4603

It has been hypothesized that peripherally restricted NMDA receptor antagonists may be effective analgesics for osteoarthritis pain. A class of novel quinoxalinedione atropisomers, first discovered for an NMDA receptor antagonist program for the trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcf8a8aa89569f777c79f4224db99ed
https://doi.org/10.1016/j.bmcl.2007.05.083

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Role of inflammation and cellular stress in brain injury and central nervous system diseases

Autor: Frank C. Barone, Kenneth S. Kilgore

Publikováno v: Clinical Neuroscience Research. 6:329-356

The importance of cytokines and the complement system in the propagation and maintenance of the brain inflammatory response to injury are emphasised. Much data supports the case that ischemia and trauma elicit an inflammatory response in the injured

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a2d028e34a847a3f72f529ead1d58b1
https://doi.org/10.1016/j.cnr.2006.09.010

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Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis

Autor: Roberto E. Guzman, Kenneth S. Kilgore, Susan L. Calcaterra, D.J Schrier, Susan E. Bove, C.M Huber, Rachel M. Brooker, P.L. Juneau

Publikováno v: Osteoarthritis and Cartilage. 11:821-830

Objective: To describe an in vivo model in the rat in which change in weight distribution is used as a measure of disease progression and efficacy of acetaminophen and two nonsteroidal anti-inflammatory drugs (NSAIDs) in a model of monosodium iodoace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd130229a0200e8c187af573c05583e5
https://doi.org/10.1016/s1063-4584(03)00163-8

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Role of Inflammatory Mediators in Thrombogenesis

Autor: Ronald J. Shebuski, Kenneth S. Kilgore

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 300:729-735

The role of inflammation in cardiovascular disease and especially in thrombogenesis has become increasingly recognized as an important component of the overall disease process. Plaque rupture promotes activation of the inflammatory response and incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c245c58e8561eb3df082c6b1d06ed85
https://doi.org/10.1124/jpet.300.3.729

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[Untitled]

Autor: Kenneth S. Kilgore, Paul J. Kuipers, Autumn J. Broady, Keith B. Naylor, Nicole L. Tramontini, Colleen M. Huber, Kerri L. Murphy

Publikováno v: Inflammation. 26:311-319

The complement system is thought to be a major physiological mediator of injury in a number of diseases including rheumatoid arthritis (RA). The membrane attack complex (MAC) of complement has been detected in RA tissue, suggesting that the MAC may b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bafe343200188187ed66d3d21c093e9f
https://doi.org/10.1023/a:1021420903355

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Opioids confer myocardial tolerance to ischemia: Interaction of delta opioid agonists and antagonists

Autor: Charles F. Schwartz, Steven F. Bolling, Vinay Badhwar, Tsung-Ping Su, Peter R. Oeltgen, Kenneth S. Kilgore

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 122(3):476-481

Background: Mammalian hibernation biology is now known to be mediated by delta opioids. The altered myocellular physiology of hibernation closely parallels that of hypothermic ischemia used to protect the heart for cardiac surgery. Methods and Result

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