Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Kenneth S. Graham"'
Autor:
Sisi Zhang, Caterina Riccardi, Dane Carlson, Douglas Kamen, Kenneth S. Graham, Mohammed Shameem, Hanne Bak, Hui Xiao, Ning Li
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTPolysorbates (PSs) are a class of surfactants commonly used in the formulation of protein therapeutic agents to provide protection against denaturation and aggregation. When the PS in these drug formulations degrades, loss of stabilization of
Externí odkaz:
https://doaj.org/article/cae28374819141db8e01ae767ca1c6a7
Low pKa of Lys promotes glycation at one complementarity-determining region of a bispecific antibody
Autor:
Xiaobin Xu, Jessica Ann O'Callaghan, Zachary Guarnero, Haibo Qiu, Ning Li, Terra Potocky, Douglas E. Kamen, Kenneth S. Graham, Mohammed Shameem, Teng-Chieh Yang
Publikováno v:
Biophysical Journal. 121:1081-1093
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16f1f7befc26b8b7a2252b3ae6212e7d
https://doi.org/10.1016/j.bpj.2022.02.002
https://doi.org/10.1016/j.bpj.2022.02.002
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Cardiac parasympathetic activity may be non-invasively investigated using heart rate variability (HRV), although HRV is not widely accepted to reflect sympathetic activity. Instead, cardiac sympathetic activity may be investigated using systolic time
Externí odkaz:
https://doaj.org/article/60913847d22042aaa06d3980ce58e6ce
Autor:
Xiaobin, Xu, Jessica Ann, O'Callaghan, Zachary, Guarnero, Haibo, Qiu, Ning, Li, Terra, Potocky, Douglas E, Kamen, Kenneth S, Graham, Mohammed, Shameem, Teng-Chieh, Yang
Publikováno v:
Biophysical journal. 121(6)
Protein glycation is a common, normally innocuous, post-translational modification in therapeutic monoclonal antibodies. However, when glycation occurs on complementarity-determining regions (CDRs) of a therapeutic monoclonal antibody, its biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1247304182fa96cf0b80cdc6994ab8df
https://pubmed.ncbi.nlm.nih.gov/35122736
https://pubmed.ncbi.nlm.nih.gov/35122736
Autor:
Mohammed Shameem, Ashwin Parenky, Hunter H Chen, Kenneth S. Graham, Amardeep S Bhalla, Saurabh Wadhwa
Publikováno v:
AAPS PharmSciTech
Intravitreal (IVT) administration of therapeutics is the standard of care for treatment of back-of-eye disorders. Although a common procedure performed by retinal specialists, IVT administration is associated with unique challenges related to drug pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3aefd9baf4ca4d7a5dbbd546ce8fcbd
http://europepmc.org/articles/PMC7952281
http://europepmc.org/articles/PMC7952281
Autor:
Gitanjali Sharma, Chen Zhou, Saurabh Wadhwa, Ashwin C. Parenky, Kenneth S. Graham, Amardeep S. Bhalla, Dingjiang Liu, Hunter H. Chen, Mohammed Shameem
Publikováno v:
Ophthalmic Product Development ISBN: 9783030763664
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8e363b9163abc177f3d0c51cc3cefc1
https://doi.org/10.1007/978-3-030-76367-1_17
https://doi.org/10.1007/978-3-030-76367-1_17
Autor:
Peter J Clothier, Nathan J Washington, Kenneth S. Graham, Kurt L. Mudie, Clare MacMahon, Kylie A Steel
Background: Some studies show that wearing compression garments (CGs) improves balance performance. However, the overall evidence supporting their use for balance improvement is inconclusive. Objective: This study aimed to further explore the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7a29cda5fa67fa1b9c14594a617801
Publikováno v:
Journal of Science and Medicine in Sport. 21:1079-1084
OBJECTIVES:This study investigated indirect measures of post-exercise parasympathetic reactivation (using heart-rate-variability, HRV) and sympathetic withdrawal (using systolic-time-intervals, STI) following upper- and lower-body exercise. DESIGN:Ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5509861fd3f9956d4f8edbd1223da0c9
https://doi.org/10.1016/j.jsams.2018.01.015
https://doi.org/10.1016/j.jsams.2018.01.015
Autor:
Pamela Krueger, James Shevchuk, Joannie Bautista, Macdonald Lynn, Natasha Levenkova, Saurabh Wadhwa, Cagan Gurer, Johanna Hansen, Douglas MacDonald, Tammy T. Huang, Ashique Rafique, Kenneth S. Graham, Lakeisha Esau, Matthew C. Franklin, George Ehrlich, Ashok Badithe, George D. Yancopoulos, Maggie Zhong, Andrew J. Murphy, Chunguang Guo, Vera Voronina, Robert Babb, Gang Chen, Naxin Tu, Morton Lori C, Craig Grant, William Poueymirou, Karoline A Meagher, Wojtek Auerbach, John Mcwhirter
Publikováno v:
Proc Natl Acad Sci U S A
We describe a Kappa-on-Heavy (KoH) mouse that produces a class of highly diverse, fully human, antibody-like agents. This mouse was made by replacing the germline variable sequences of both the Ig heavy-chain (IgH) and Ig kappa (IgK) loci with the hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce38a80d6c07387d0b8c0cfcb5399c34
https://pubmed.ncbi.nlm.nih.gov/31879340
https://pubmed.ncbi.nlm.nih.gov/31879340
Publikováno v:
European Journal of Applied Physiology. 116:697-706
This study investigated whether short-term heart rate variability (HRV) can be used to differentiate between the immediate recovery periods following three different intensities of preceding exercise. 12 males cycled for 8 min at three intensities: L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0f6fa6b1e6933560190056fe22e494
https://doi.org/10.1007/s00421-016-3327-9
https://doi.org/10.1007/s00421-016-3327-9