Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kenneth S. Cameron"'
Autor:
Kenneth S. Cameron, Jen Konczal, Andrea Gohlke, Gillian Goodwin, Justin Bower, C.G. Gray, Duncan McArthur, Alexander Schuettelkopf, Peter N. Brown, Angelo Pugliese, Martin J. Drysdale, Mokdad Mezna, Heather McKinnon
Publikováno v:
Biophysical Journal. 114:30a-31a
Autor:
John Bruin, William Hamilton, Emma Kinghorn, Kenneth S. Cameron, Paul Westwood, Jiaqiang Cai, Kathryn Everett, Clive Long, Maureen Dempster, Chris Claxton, Xavier Fradera, D. Jonathan Bennett, Robinson John E, Simone Belshaw, Philip Jones, Wullie Arbuckle, Mark Baugh, Iain Martin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:932-935
Based on the theoretical understanding of the in vivo lysosomotropism, by adjusting the pka of basic nitrogen containing cathepsin S inhibitors, a set of compounds with pka 6–8 were identified to have excellent cell based Lip10 activity, yet avoidi
Autor:
D. Jonathan Bennett, Kenneth S. Cameron, John Bruin, Mario van Zeeland, Xavier Fradera, J.C.M. Uitdehaag, Emma Kinghorn, Jiaqiang Cai, Maureen Dempster, Paul Westwood, Lucy Popplestone, Mark Baugh, Robinson John E, William Hamilton, Clive Long
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4507-4510
Using computer aided modelling studies, a new extended P2/S2 interaction was identified. This extended region can accommodate a variety of functional groups, such as aryls and basic amines. It was discovered that the N3 nitrogen of the pyrimidine-2-c
Autor:
T.M. Meulemans, Jonathan Gillespie, D. Jonathan Bennett, Darcey Black, Ann Mitchell, Kenneth S. Cameron, J.C.M. Uitdehaag, Maurice Maidment, Mario van Zeeland, Fiona Elizabeth Andrews, Sylviane Boucharens, Allard Kaptein, Maureen Dempster, Emma Kinghorn, Mark Baugh, Jiaqiang Cai, Philip Jones, Zoran Rankovic, Paul Westwood, Martijn Bastiani, Iain Martin, Iain Cumming, Leon van Berkom, Paul Vink, Paul Scullion, Xavier Fradera, John Bruin, Robinson John E, William Hamilton, Clive Long
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4350-4354
6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile analogues were identified as potent and selective cathepsin S inhibitor against both purified enzyme and in human JY cell based cellular assays. This core has a very stable thio-trapping nitrile war-h
Publikováno v:
Magnetic Resonance in Chemistry. 43:647-653
The solution-state NMR spectra of a per-6-substituted γ-cyclodextrin show some interesting dynamic properties. At high temperature (353 K), the 1H NMR spectrum shows dynamic averaging of the different conformations. This averaging is no longer obser
Autor:
Lee Fielding, Kenneth S. Cameron
Publikováno v:
Magnetic Resonance in Chemistry. 40:S106-S109
The complexes formed by the steroid rocuronium bromide with four different cyclodextrins (β-cyclodextrin, γ-cyclodextrin, Org 26054 and Org 25969) were investigated. The diffusion coefficients of the steroid–cyclodextrin complexes were 6–15% lo
Autor:
M.-q. Zhang, J. K. Clark, L. Fielding, Kenneth S. Cameron, Alan Cooper, Palin R, Rutherford Sj
Publikováno v:
Organic Letters. 4:3403-3406
A series of per-6-substituted cyclodextrin derivatives was synthesized as synthetic host molecules for rocuronium, a steroidal muscle relaxant. By forming host-guest complexes with rocuronium, these cyclodextrin derivatives reverse the muscle relaxat
Publikováno v:
Journal of Combinatorial Chemistry. 4:199-203
A study into the effect of reaction variables on the quaternization of REM resin-bound tertiary amines was undertaken. The influence of resin matrix, solvent, reaction time, temperature, and amount of quaternization agent on the outcome of reaction w
Publikováno v:
Magnetic Resonance in Chemistry. 40:251-260
The interaction of Rocuronium Bromide, and a model steroid Org 7402, with three cyclodextrins (β-cyclodextrin, γ-cyclodextrin and Org 25969) was studied by solution state NMR experiments. Stoichiometries and binding constants were determined from 1
Publikováno v:
Journal of the American Chemical Society. 119:7555-7560
13C CP/MAS NMR studies were carried out on trans-1,2-cyclopentanediol, on 4,4-dimethyl-trans-1,2-cyclopentanediol, and on sulfolane at variable temperatures. The spectra showed evidence of three dynamic solid-state processes: hydrogen bond exchange,