Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Kenneth S, Chen"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The recent progress in the prediction of protein structures marked a historical milestone. AlphaFold predicted 200 million protein models with an accuracy comparable to experimental methods. Protein structures are widely used to understand e
Externí odkaz:
https://doaj.org/article/27726e4358d04793a10ff059fe94d8d6
Autor:
Lin Xu, Joshua L. Pierce, Angelica Sanchez, Kenneth S. Chen, Abhay A. Shukla, Nicholas J. Fustino, Sarai H. Stuart, Aditya Bagrodia, Xue Xiao, Lei Guo, Mark D. Krailo, Furqan Shaikh, Deborah F. Billmire, Farzana Pashankar, Jessica Bestrashniy, J. Wolter Oosterhuis, Ad J. M. Gillis, Yang Xie, Lisa Teot, Jaume Mora, Jenny N. Poynter, Dinesh Rakheja, Leendert H. J. Looijenga, Bruce W. Draper, A. Lindsay Frazier, James F. Amatruda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Germ cell tumors (GCTs) are neoplasms of the testis, ovary and extragonadal sites that occur in infants, children, adolescents and adults. Post-pubertal (type II) malignant GCTs may present as seminoma, non-seminoma or mixed histologies. In
Externí odkaz:
https://doaj.org/article/7de0ec00eddb4344af90c7a9512816da
Autor:
Kris Ann P. Schultz, Murali Chintagumpala, Jin Piao, Kenneth S. Chen, Rachana Shah, Robyn D. Gartrell, Emily Christison-Lagay, Farzana Pashnakar, Jesse L. Berry, Allison F. O’Neill, Lauren M. Vasta, Ashley Flynn, Sarah G. Mitchell, Brittani KN. Seynnaeve, Jeremy Rosenblum, Samara L. Potter, Junne Kamihara, Carlos Rodriguez-Galindo, Douglas S. Hawkins, Theodore W. Laetsch
Publikováno v:
EJC Paediatric Oncology, Vol 2, Iss , Pp 100024- (2023)
While all childhood cancers are rare, tumors that are particularly infrequent or underrepresented within pediatrics are studied under the umbrella of the Children’s Oncology Group Rare Tumor committee, divided into the Retinoblastoma and Infrequent
Externí odkaz:
https://doaj.org/article/1d78ae7efc7f48d693fb7d9771fddd5b
Autor:
Kirill E Medvedev, Anna V Savelyeva, Kenneth S Chen, Aditya Bagrodia, Liwei Jia, Nick V Grishin
Publikováno v:
Cancer Informatics, Vol 21 (2022)
Objective: Testicular germ cell tumors (TGCT) are the most common solid malignancy in adolescent and young men, with a rising incidence over the past 20 years. Overall, TGCTs are second in terms of the average life years lost per person dying of canc
Externí odkaz:
https://doaj.org/article/751fd8a7bb3a49669b1093a57121bf76
Autor:
James F. Amatruda, Dinesh Rakheja, Theodore W. Laetsch, Leendert H.J. Looijenga, Lawrence Lum, A. Lindsay Frazier, Payal Kapur, Kiyoshi Yamaguchi, Sarai H. Stuart, Christina Ateek, Albert Budhipramono, Emily K. Stroup, Abhay A. Shukla, Nicholas J. Fustino, Kenneth S. Chen
Germ cell tumors (GCT) are malignant tumors that arise from pluripotent embryonic germ cells and occur in children and young adults. GCTs are treated with cisplatin-based regimens which, while overall effective, fail to cure all patients and cause si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d02f346e8bfa5d168d6fbe51a99d23af
https://doi.org/10.1158/1535-7163.c.6538071.v1
https://doi.org/10.1158/1535-7163.c.6538071.v1
Autor:
Lin Xu, Kavita Desai, Jiwoong Kim, Qinbo Zhou, Lei Guo, Xue Xiao, Yanfeng Zhang, Li Zhou, Aysen Yuksel, Daniel R. Catchpoole, James F. Amatruda, Kenneth S. Chen
Wilms tumor, the most common kidney cancer in pediatrics, arises from embryonic renal progenitors. Although many patients are cured with multimodal therapy, outcomes remain poor for those with high-risk features. Recent sequencing efforts have provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::362139211c3330529593a37ae8624cdd
https://doi.org/10.1101/2023.01.30.23285117
https://doi.org/10.1101/2023.01.30.23285117
Autor:
Jessica N. Hatton, Megan N. Frone, Hannah C. Cox, Stephanie B. Crowley, Susan Hiraki, Noriko N. Yokoyama, Noura S. Abul-Husn, James F. Amatruda, Michael J. Anderson, Xavier Bofill-De Ros, Ann G. Carr, Elizabeth C. Chao, Kenneth S. Chen, Shuo Gu, Cecilia Higgs, Jerry Machado, Deborah Ritter, Kris Ann P. Schultz, Emily R. Soper, Mona K. Wu, Jessica L. Mester, Jung Kim, William D. Foulkes, Leora Witkowski, Douglas R. Stewart
Publikováno v:
Human Mutation.
Germline pathogenic variants in DICER1 predispose individuals to develop a variety of benign and malignant tumors. Accurate variant curation and classification are essential for reliable diagnosis of DICER1-related tumor predisposition and the identi
Publikováno v:
Cancer Research. 83:2689-2689
Nephroblastomas or Wilms tumors are the most common pediatric renal cancer. Across all cases, the 5-year overall survival is over 90%. This is largely in part due to brute-force, chemotherapy regimens such as dactinomycin (actD) that have been routin
Autor:
Kelsi R. Willis, Adwait A. Sathe, Chao Xing, Prasad Koduru, Maddy Artunduaga, Erin B. Butler, Jason Y. Park, Raushan T. Kurmasheva, Peter J. Houghton, Kenneth S. Chen, Dinesh Rakheja
Publikováno v:
J Pediatr Hematol Oncol
Primary extrarenal Wilms tumors are rare neoplasms that are presumed to arise from metanephric or mesonephric remnants outside of the kidney. Their pathogenesis is debated but has not been studied, and there are no reports of genomic descriptions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa750dd45b953259183ff8d2c753c81
https://europepmc.org/articles/PMC9035038/
https://europepmc.org/articles/PMC9035038/
Autor:
Adeline Yang, Alison Patterson, Tara Pavlock, Kenneth S. Chen, Jeffrey Gagan, Mark E. Hatley, A. Lindsay Frazier, James F. Amatruda, Theodore W. Laetsch, Dinesh Rakheja
Publikováno v:
Pediatr Blood Cancer
Though outcomes for patients with recurrent/refractory malignant germ cell tumors (mGCTs) are poor, therapies targeting mTOR and EGFR inhibition have shown promise in vitro. We hypothesized that the combination of sirolimus and erlotinib will show ac