Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Kenneth S, Campbell"'
Autor:
Thomas Kampourakis, Saraswathi Ponnam, Kenneth S. Campbell, Austin Wellette-Hunsucker, Daniel Koch
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Phosphorylation of cardiac myosin binding protein-C (cMyBP-C) is a determinant of cardiac myofilament function. Although cMyBP-C phosphorylation by various protein kinases has been extensively studied, the influence of protein phosphatases o
Externí odkaz:
https://doaj.org/article/7a23efe4b40e463b8186edcb27c59c8c
Publikováno v:
Frontiers in Virology, Vol 4 (2024)
Heart disease is the leading cause of death worldwide. Myocarditis, or inflammation of the cardiac muscle, is estimated to cause up to 1.5 million cases annually, with viral infection being the most common disease culprit. Past studies have shown tha
Externí odkaz:
https://doaj.org/article/935f2ffe0c6c4a949994a60477c8b70c
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-6 (2023)
Abstract Objective Identifying viral genomes in human heart tissues is critical for disease diagnosis and assessment of cardiovascular damage. Human heart tissue samples obtained during a biopsy procedure are routinely used to test for the presence o
Externí odkaz:
https://doaj.org/article/0fbd701d340c40d3be8e239d1703ae83
Autor:
Glenn Carrington, Abbi Hau, Sarah Kosta, Hannah F. Dugdale, Francesco Muntoni, Adele D’Amico, Peter Van den Bergh, Norma B. Romero, Edoardo Malfatti, Juan Jesus Vilchez, Anders Oldfors, Sander Pajusalu, Katrin Õunap, Marta Giralt-Pujol, Edmar Zanoteli, Kenneth S. Campbell, Hiroyuki Iwamoto, Michelle Peckham, Julien Ochala
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Myosin heavy chains encoded by MYH7 and MYH2 are abundant in human skeletal muscle and important for muscle contraction. However, it is unclear how mutations in these genes disrupt myosin structure and function leading to skeletal muscle myopathies t
Externí odkaz:
https://doaj.org/article/59ff4fd339fd4cbaa9a588a2470f9192
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 20 (2023)
Background Omecamtiv mecarbil (OM) and danicamtiv both increase myocardial force output by selectively activating myosin within the cardiac sarcomere. Enhanced force generation is presumably due to an increase in the total number of myosin heads boun
Externí odkaz:
https://doaj.org/article/5c2e1e8ef52541f6b9bf787ac3d6ed92
Autor:
Priyanka Parijat, Saraswathi Ponnam, Seetharamaiah Attili, Kenneth S. Campbell, Mohammed El-Mezgueldi, Mark Pfuhl, Thomas Kampourakis
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The large unmet demand for new heart failure therapeutics is widely acknowledged. Over the last decades the contractile myofilaments themselves have emerged as an attractive target for the development of new therapeutics for both systolic an
Externí odkaz:
https://doaj.org/article/426170449f754cb48a52dcf44aedf251
Autor:
Joy Mojumder, Lei Fan, Thuy Nguyen, Kenneth S. Campbell, Jonathan F. Wenk, Julius M. Guccione, Theodore Abraham, Lik Chuan Lee
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Hypertrophic cardiomyopathy (HCM) is a genetic heart disease that is associated with many pathological features, such as a reduction in global longitudinal strain (GLS), myofiber disarray and hypertrophy. The effects of these features on lef
Externí odkaz:
https://doaj.org/article/ba78ed35645a457ab6c00892b266e954
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
With the advent of next-generation whole genome sequencing, many variants of uncertain significance (VUS) have been identified in individuals suffering from inheritable hypertrophic cardiomyopathy (HCM). Unfortunately, this classification of a geneti
Externí odkaz:
https://doaj.org/article/c87043c9a16545e6aa5be99cbc31d3be
Autor:
Alice Main, Andri Boguslavskyi, Jacqueline Howie, Chien-Wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date. In the heart, S-palmitoylation reg
Externí odkaz:
https://doaj.org/article/7cbe5c5a5f744ee8954ab054d0919e50
Autor:
Kate Møller Herum, Guangzheng Weng, Konstantin Kahnert, Rebekah Waikel, Greg Milburn, Autumn Conger, Paul Anaya, Kenneth S. Campbell, Alicia Lundby, Kyoung Jae Won, Cord Brakebusch
Publikováno v:
Matrix Biology Plus, Vol 15, Iss , Pp 100113- (2022)
Many heart diseases are associated with fibrosis, but it is unclear whether different types of heart disease correlate with different subtypes of activated fibroblasts and to which extent such diversity is modeled during in vitro activation of primar
Externí odkaz:
https://doaj.org/article/048f36aac8354a93b6543651b0e311ae