Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Kenneth R. Tindall"'
Autor:
James A. Swenberg, F. Michael Yakes, David E. Watson, Bennett Van Houten, Kenneth R. Tindall, Leona D. Samson, Joseph A. Ladapo, Robert W. Sobol, Jun Nakamura, Julie K. Horton, Esther W. Hou, Samuel H. Wilson
Publikováno v:
Proceedings of the National Academy of Sciences. 99:6860-6865
The long-term effect of exposure to DNA alkylating agents is entwined with the cell's genetic capacity for DNA repair and appropriate DNA damage responses. A unique combination of environmental exposure and deficiency in these responses can lead to g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58bc082f51274b8b163e3145c24ddf8b
https://doi.org/10.1073/pnas.092662499
https://doi.org/10.1073/pnas.092662499
Autor:
John L. Jakubczak, Glenn Merlino, William J. Muller, Kenneth R. Tindall, Shiquan Liu, Gregory L. Erexson, Sankar Adhya, Richard Chan, Susan Garges, Wenjing Liu
Publikováno v:
Proceedings of the National Academy of Sciences. 99:3770-3775
It has been argued that genetic instability is required to generate the myriad mutations that fuel tumor initiation and progression and, in fact, patients with heritable cancer susceptibility syndromes harbor defects in specific genes that normally m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e5cae9aa39884615c6ad884053f65a0
https://doi.org/10.1073/pnas.052710299
https://doi.org/10.1073/pnas.052710299
Autor:
David B. Dunson, Kenneth R. Tindall
Publikováno v:
Genetics. 156:1411-1418
Studies that examine both the frequency of gene mutation and the pattern or spectrum of mutational changes can be used to identify chemical mutagens and to explore the molecular mechanisms of mutagenesis. In this article, we propose a Bayesian hierar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642893e9352d0bbaa8d53338e80ea9ff
https://doi.org/10.1093/genetics/156.3.1411
https://doi.org/10.1093/genetics/156.3.1411
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 427:67-78
Recently, we showed that the cytotoxic and mutagenic response in human cells to the model SN2 alkylating agent methyl methanesulfonate (MMS) can be modulated by the mismatch repair (MMR) pathway. That is, human cancer cell lines defective in MMR are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1d972f3eff941930c713394b39fcfb
https://doi.org/10.1016/s0027-5107(99)00091-3
https://doi.org/10.1016/s0027-5107(99)00091-3
Publikováno v:
Environmental and Molecular Mutagenesis. 34:90-96
We have established and characterized primary mouse and rat cell strains for studies designed to complement in vivo gene mutation assays using the Big Blue(R) mouse or rat. Primary fibroblast cell strains, designated BBM1 and BBR1, were derived from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8249c2ba5c09047a2118fcc5a42feeea
https://doi.org/10.1002/(sici)1098-2280(1999)34:2/3<90::aid-em6>3.0.co
https://doi.org/10.1002/(sici)1098-2280(1999)34:2/3<90::aid-em6>3.0.co
Autor:
Minoru Koi, Kenneth R. Tindall, J. Carl Barrett, Warren E. Glaab, Asad Umar, John I. Risinger, Thomas A. Kunkel
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 402:15-22
The study of the multiple functions of mismatch repair genes in humans is being facilitated by the use of human tumor cell lines carrying defined MMR gene mutations. Such cell lines have elevated spontaneous mutation rates and may accumulate mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5767563c8346ac96fdb82fc03006283
https://doi.org/10.1016/s0027-5107(97)00277-7
https://doi.org/10.1016/s0027-5107(97)00277-7
Autor:
Kenneth R. Tindall, J. Carl Barrett, Asad Umar, Thomas A. Kunkel, Warren E. Glaab, John I. Risinger
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 398:197-207
Resistance to the cytotoxic effects of S N 1 alkylating agents such as N -methyl- N ′-nitro- N -nitrosoguanidine (MNNG) and N -methyl- N -nitrosourea (MNU) is well established in mismatch repair-defective cells, however, little is known about the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba2ba37547639dc64889f9b15b6b61f
https://doi.org/10.1016/s0027-5107(98)00004-9
https://doi.org/10.1016/s0027-5107(98)00004-9
Publikováno v:
Environmental and Molecular Mutagenesis. 32:47-55
Amsacrine is an acridine-derived inhibitor of topoisomerase II that intercalates into DNA. We performed a detailed molecular analysis of 6-thioguanine (6-TG)-resistant mutant colonies arising in AS52 cells following Amsacrine treatment. AS52 cells ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eef4d9d5e2e716782e01f71ce37d0fb
https://doi.org/10.1002/(sici)1098-2280(1998)32:1<47::aid-em6>3.0.co
https://doi.org/10.1002/(sici)1098-2280(1998)32:1<47::aid-em6>3.0.co
Autor:
Kenneth R. Tindall, M.D. Shelby
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 388:99-109
A collaborative study to systematically assess transgenic mouse mutation assays as screens for germ cell mutagens has been conducted. Three male mouse germ cell mutagens (ENU, iPMS and MMS) were selected for testing. This paper provides a brief revie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07732cd6f239434d127b676deef8fd4e
https://doi.org/10.1016/s1383-5718(96)00106-4
https://doi.org/10.1016/s1383-5718(96)00106-4
Autor:
Brenda Rogers, Kenneth R. Tindall, J. Scott Provost, James Holcroft, Barry W. Glickman, David Walsh, H. Erfle, Johan G. de Boer
Publikováno v:
Environmental and Molecular Mutagenesis. 30:273-286
The advent of transgenic technology has greatly facilitated the study of mutation in animals in vivo. The Big Blue® mouse system, transgenic for the lacl gene, permits not only the quantification of mutations in different tissues but also provides f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cecf099ed97442fb9d454c151dcf396
https://doi.org/10.1002/(sici)1098-2280(1997)30:3<273::aid-em5>3.0.co
https://doi.org/10.1002/(sici)1098-2280(1997)30:3<273::aid-em5>3.0.co