Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Kenneth R. Johnson"'
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168159 (2016)
Otitis media (OM), inflammation of the middle ear, is a common cause of hearing loss in children and in patients with many different syndromic diseases. Studies of the human population and mouse models have revealed that OM is a multifactorial diseas
Externí odkaz:
https://doaj.org/article/fd58f69e50d6433d96828e3146d98905
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
The cupula is a gelatinous membrane overlying the crista ampullaris of the semicircular canal, important for sensing rotation of the head and critical for normal balance. Recently the zona pellucida like domain containing 1 protein (ZPLD1, also known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa31ac51a5d2b0a0c270dcf784eb80b9
http://link.springer.com/article/10.1038/s41598-019-48835-5
http://link.springer.com/article/10.1038/s41598-019-48835-5
Autor:
Qing Fang, Michelle T. Fleming, Alexandre Z. Daly, Amanda H. Mortensen, Kenneth R. Johnson, Sally A. Camper, Thomas J. Jones
Publikováno v:
Mammalian Genome. 30:5-22
Maternal and fetal sources of thyroid hormone are important for the development of many organ systems. Thyroid hormone deficiency causes variable intellectual disability and hearing impairment in mouse and man, but the basis for this variation is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8209eaaf6806ad5756cc42a1aedda72b
https://doi.org/10.1007/s00335-019-09792-6
https://doi.org/10.1007/s00335-019-09792-6
Autor:
Melissa A Calton, Dasom Lee, Srividya Sundaresan, Diana Mendus, Rose Leu, Felix Wangsawihardja, Kenneth R Johnson, Mirna Mustapha
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e94549 (2014)
Early cochlear development is marked by an exuberant outgrowth of neurites that innervate multiple targets. The establishment of mature cochlear neural circuits is, however, dependent on the pruning of inappropriate axons and synaptic connections. Su
Externí odkaz:
https://doaj.org/article/f56dd616e6354a47b15481614e9782d9
Autor:
Vishnu Hosur, Melissa L Cox, Lisa M Burzenski, Rebecca L Riding, Lynn Alley, Bonnie L Lyons, Anoop Kavirayani, Kimberly A Martin, Gregory A Cox, Kenneth R Johnson, Leonard D Shultz
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53426 (2013)
"Hairpatches" (Hpt) is a naturally occurring, autosomal semi-dominant mouse mutation. Hpt/Hpt homozygotes die in utero, while Hpt/+ heterozygotes exhibit progressive renal failure accompanied by patchy alopecia. This mutation is a model for the rare
Externí odkaz:
https://doaj.org/article/ce5a049eec354227b84f820d0d6f83e4
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36074 (2012)
Stereocilia, the modified microvilli projecting from the apical surfaces of the sensory hair cells of the inner ear, are essential to the mechanoelectrical transduction process underlying hearing and balance. The actin-filled stereocilia on each hair
Externí odkaz:
https://doaj.org/article/df374bfdf2d14a87a007d05ba3cf71a7
Autor:
Cong Tian, Leona H. Gagnon, Amy E. Kiernan, Benjamin E. Low, Chantal M. Longo-Guess, Michael V. Wiles, Kenneth R. Johnson
Publikováno v:
Genetics. 208:1165-1179
Distal enhancers are thought to play important roles in the spatiotemporal regulation of gene expression during embryonic development, but few predicted enhancer elements have been shown to affect transcription of their endogenous genes or to alter p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29acaba6b5cf0b5ec454f1ebb69096b3
https://doi.org/10.1534/genetics.117.300447
https://doi.org/10.1534/genetics.117.300447
Autor:
Kenneth R. Johnson, P.A. Wilmarth, Jocelyn F. Krey, Larry L. David, Peter G. Barr-Gillespie, Rachel A. Dumont
Publikováno v:
The Journal of Neuroscience. 38:843-857
Sensory hair cells require control of physical properties of their apical plasma membranes for normal development and function. Members of the ADP-ribosylation factor (ARF) small GTPase family regulate membrane trafficking and cytoskeletal assembly i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364b7762f601b60b3163960451c26b6c
https://doi.org/10.1523/jneurosci.2658-17.2017
https://doi.org/10.1523/jneurosci.2658-17.2017
Autor:
Robert Voss, Alec N. Salt, Cong Tian, Kenneth R. Johnson, Kevin K. Ohlemiller, Jared J. Hartsock, Jaclynn M. Lett, Peter S. Steyger
Publikováno v:
Hear Res
CACHD1 recently was shown to be an α2δ-like subunit that can modulate the activity of some types of voltage-gated calcium channels, including the low-voltage activated, T-type Ca(v)3 channels. CACHD1 is widely expressed in the central nervous syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d9e4bbaff1c3f613fca1d91d9ee2c3
https://doi.org/10.1016/j.heares.2021.108327
https://doi.org/10.1016/j.heares.2021.108327
Autor:
Susan Sheehan, Jaclynn M. Lett, Kevin K. Ohlemiller, Cong Tian, Chantal M. Longo-Guess, Kenneth R. Johnson, Angela D. Schrader, Leona H. Gagnon, Ron Korstanje
Publikováno v:
Human Molecular Genetics. 26:3722-3735
Mutations of the human ATP6V1B1 gene cause distal renal tubular acidosis (dRTA; OMIM #267300) often associated with sensorineural hearing impairment; however, mice with a knockout mutation of Atp6v1b1 were reported to exhibit a compensated acidosis a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f33902befe6446918594361fc9a3b06
https://doi.org/10.1093/hmg/ddx257
https://doi.org/10.1093/hmg/ddx257