Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kenneth R. Dellamaggiore"'
Autor:
David Powers, Katja Labitzke, Mark J. Rose, Kristin L. Andrews, Richard Kendall, Kenneth R. Dellamaggiore, Shon Booker, Peter Jaeckel, Silvia Materna-Reichelt, Mark H. Norman, Young-Ah Chung, Holger Beckmann, Paul L. Shaffer, Pedro J. Beltran, Hao Chen, Alexander M. Long, Petia Mitchell, Adrian L. Smith, Jennifer Dao, J. Russell Lipford, Noel D'angelo, Steven F. Bellon, Michelle Wu
Publikováno v:
Journal of Medicinal Chemistry. 58:1426-1441
The structure-based design and optimization of a novel series of selective PERK inhibitors are described resulting in the identification of 44 as a potent, highly selective, and orally active tool compound suitable for PERK pathway biology exploratio
Autor:
Kenneth R. Dellamaggiore, Rachel Myerowitz, Audrey L. Fan, Meikana Lizadjohry, George A. Chernis, Christopher P. Ouellette, Elizabeth F. Neufeld, Cecilia D. Sedano, Francis E. Baltasar, Michelle Gonzales, Chi-hong B. Chen
Publikováno v:
Proceedings of the National Academy of Sciences. 105:15908-15913
Enzyme replacement therapy for lysosomal storage diseases is currently based on endocytosis of lysosomal enzymes via the mannose or mannose 6-phosphate receptors. We are developing a technology for endocytosis of lysosomal enzymes that depends on gen