Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Kenneth R. Brittian"'
Autor:
Sujith Dassanayaka, Yuting Zheng, Andrew A. Gibb, Timothy D. Cummins, Lindsey A. McNally, Kenneth R. Brittian, Ganapathy Jagatheesan, Timothy N. Audam, Bethany W. Long, Robert E. Brainard, Steven P. Jones, Bradford G. Hill
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 440-449 (2018)
Pathological cardiac remodeling during heart failure is associated with higher levels of lipid peroxidation products and lower abundance of several aldehyde detoxification enzymes, including aldehyde dehydrogenase 2 (ALDH2). An emerging idea that cou
Externí odkaz:
https://doaj.org/article/26cadb1f9fa54a289fd9b0c378338d7a
Autor:
Regina M. Friedl, Swetha Raja, Melissa A. Metzler, Niti D. Patel, Kenneth R. Brittian, Steven P. Jones, Lisa L. Sandell
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 7 (2019)
Cleft palate is a common birth defect, occurring in approximately 1 in 1000 live births worldwide. Known etiological mechanisms of cleft palate include defects within developing palate shelf tissues, defects in mandibular growth and defects in sponta
Externí odkaz:
https://doaj.org/article/fd78ee30f105452383ae189369d67ea2
Autor:
Richard C. Li, Barry W. Row, Leila Kheirandish, Kenneth R. Brittian, Evelyne Gozal, Shang Z. Guo, Leroy R. Sachleben, Jr, David Gozal
Publikováno v:
Neurobiology of Disease, Vol 17, Iss 1, Pp 44-53 (2004)
Intermittent hypoxia (IH) during sleep induces significant neurobehavioral deficits in the rat. Since nitric oxide (NO) has been implicated in ischemia-reperfusion-related pathophysiological consequences, the temporal effects of IH (alternating 21% a
Externí odkaz:
https://doaj.org/article/20ffa3d58db6426cb6b0d2a7767ecdc6
Autor:
Kyle L. Fulghum, Juliette B. Smith, Julia Chariker, Lauren F. Garrett, Kenneth R. Brittian, Pawel K. Lorkiewicz, Lindsey A. McNally, Shizuka Uchida, Steven P. Jones, Bradford G. Hill, Helen E. Collins
Publikováno v:
Am J Physiol Heart Circ Physiol
Fulghum, K L, Smith, J B, Chariker, J, Garrett, L F, Brittian, K R, Lorkiewicz, P, McNally, L A, Uchida, S, Jones, S P, Hill, B G & Collins, H E 2022, ' Metabolic Signatures of Pregnancy-Induced Cardiac Growth ', American Journal of Physiology: Heart and Circulatory Physiology, vol. 323, no. 1, pp. H146-H164 . https://doi.org/10.1152/ajpheart.00105.2022
Fulghum, K L, Smith, J B, Chariker, J, Garrett, L F, Brittian, K R, Lorkiewicz, P, McNally, L A, Uchida, S, Jones, S P, Hill, B G & Collins, H E 2022, ' Metabolic Signatures of Pregnancy-Induced Cardiac Growth ', American Journal of Physiology: Heart and Circulatory Physiology, vol. 323, no. 1, pp. H146-H164 . https://doi.org/10.1152/ajpheart.00105.2022
The goal of this study was to develop an atlas of the metabolic, transcriptional, and proteomic changes that occur with pregnancy in the maternal heart. Timed pregnancy studies in FVB/NJ mice revealed a significant increase in heart size by day 8 of
Autor:
Ghazal Sadri, Annalara G. Fischer, Kenneth R. Brittian, Erin Elliott, Matthew A. Nystoriak, Shizuka Uchida, Marcin Wysoczynski, Andrew Leask, Steven P. Jones, Joseph B. Moore
Publikováno v:
Sadri, G, Fischer, A G, Brittian, K R, Elliott, E, Nystoriak, M A, Uchida, S, Wysoczynski, M, Leask, A, Jones, S P & Moore IV, J B 2022, ' Collagen Type XIX Regulates Cardiac Extracellular Matrix Structure and Ventricular Function ', Matrix Biology, vol. 109, pp. 49-69 . https://doi.org/10.1016/j.matbio.2022.03.007
The cardiac extracellular matrix plays essential roles in homeostasis and injury responses. Although the role of fibrillar collagens have been thoroughly documented, the functions of non-fibrillar collagen members remain underexplored. These include
Autor:
Peter J. Kilfoil, Aruni Bhatnagar, Frank J. Raucci, Xuemei Hu, Steven P. Jones, Matthew A. Nystoriak, Srinivas M. Tipparaju, Kenneth R. Brittian, Deqing Zhang, Jared Tur, Kalyan C. Chapalamadugu
Publikováno v:
J Mol Cell Cardiol
Voltage-gated potassium (Kv) channels control myocardial repolarization. Pore-forming Kvα proteins associate with intracellular Kvβ subunits, which bind pyridine nucleotides with high affinity and differentially regulate channel trafficking, plasma
Autor:
Caitlin M Howard, Lauren F Garrett, Daniel J. Conklin, Igor N. Zelko, Marina V Malovichko, Sanjay Srivastava, Steven P. Jones, Kenneth R. Brittian, Shizuka Uchida, Sujith Dassanayaka
Publikováno v:
Toxicol Sci
Zelko, I N, Dassanayaka, S, Malovichko, M V, Howard, C M, Garrett, L F, Uchida, S, Brittian, K R, Conklin, D J, Jones, S P & Srivastava, S 2021, ' Chronic Benzene Exposure Aggravates Pressure Overload-Induced Cardiac Dysfunction ', Toxicological Sciences, vol. 185, no. 1, pp. 64-76 . https://doi.org/10.1093/toxsci/kfab125
Zelko, I N, Dassanayaka, S, Malovichko, M V, Howard, C M, Garrett, L F, Uchida, S, Brittian, K R, Conklin, D J, Jones, S P & Srivastava, S 2021, ' Chronic Benzene Exposure Aggravates Pressure Overload-Induced Cardiac Dysfunction ', Toxicological Sciences, vol. 185, no. 1, pp. 64-76 . https://doi.org/10.1093/toxsci/kfab125
Benzene is a ubiquitous environmental pollutant abundant in household products, petrochemicals and cigarette smoke. Benzene is a well-known carcinogen in humans and experimental animals; however, little is known about the cardiovascular toxicity of b
Autor:
James Bradley, Sujith Dassanayaka, Yi Wei Zheng, Szilvia Herczeg, Caitlin M Howard, Bradford G. Hill, Matthew W. Frank, Lauren F Garrett, Tamás Radovits, Suzanne Jackowski, Miklós Pólos, Kenneth R. Brittian, Steven P. Jones, Shizuka Uchida, Timothy N. Audam, Béla Merkely, Kyle L Fulghum
Publikováno v:
Am J Physiol Heart Circ Physiol
Coenzyme A (CoA) is an essential cofactor required for intermediary metabolism. Perturbations in homeostasis of CoA have been implicated in various pathologies; however, whether CoA homeostasis is changed and the extent to which CoA levels contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d0fef2483bc01a7cdd55989c7737b2
https://europepmc.org/articles/PMC8794231/
https://europepmc.org/articles/PMC8794231/
Late-Breaking Basic Science Abstracts From the American Heart Association’s Scientific Sessions 2020
Autor:
Foster Mallory L, Steven P. Jones, McNally Lindsey A, Collins Helen E, Shizuka Uchida, Kenneth R. Brittian, Nystoriak Matthew A, Bradford G. Hill, Fulghum Kyle
Publikováno v:
Circulation Research. 127
Autor:
Bradford G. Hill, Mallory L Foster, Shizuka Uchida, Kenneth R. Brittian, Matthew A. Nystoriak, Steven P. Jones, Helen E. Collins, Lindsey A. McNally, Kyle L Fulghum
Publikováno v:
Circulation Research. 127
Cardiovascular disease is the leading cause of death in pregnant and postpartum women. During pregnancy, the maternal heart rapidly adapts to the increasing physiological and metabolic demands of the growing fetus. This adaptation often takes the for