The efficacy of different biomarkers and endpoints to refine referrals for suspected prostate cancer: the TARGET study (Tiered integrAted tests for eaRly diaGnosis of clinically significant ProstatE Tumours)

Autor: Artitaya Lophatananon, Kenneth R. Muir, Vincent J. Gnanapragasam

Publikováno v: BMC Medicine, Vol 22, Iss 1, Pp 1-10 (2024)

Abstract Background The majority of men referred with a raised PSA for suspected prostate cancer will receive unnecessary tertiary investigations including MRI and biopsy. Here, we compared different types of biomarkers to refine tertiary referrals a

Externí odkaz: https://doaj.org/article/940d450a9266478ea32be48d83014378

The association of herpes zoster and influenza vaccinations with the risk of developing dementia: a population-based cohort study within the UK Clinical Practice Research Datalink

Autor: Artitaya Lophatananon, Matthew Carr, Brian Mcmillan, Curtis Dobson, Ruth Itzhaki, Rosa Parisi, Darren M. Ashcroft, Kenneth R. Muir

Publikováno v: BMC Public Health, Vol 23, Iss 1, Pp 1-12 (2023)

Abstract Background Dementia affects ability to remember, think, or make decisions that interfere with doing everyday activities. There is no cure, therefore any prevention or delay of the onset is of importance. This study aims to investigate the as

Externí odkaz: https://doaj.org/article/16b276f79589496b8f222dcf95831e28

Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context

Autor: James Yarmolinsky, Jamie W. Robinson, Daniela Mariosa, Ville Karhunen, Jian Huang, Niki Dimou, Neil Murphy, Kimberley Burrows, Emmanouil Bouras, Karl Smith-Byrne, Sarah J. Lewis, Tessel E. Galesloot, Lambertus A. Kiemeney, Sita Vermeulen, Paul Martin, Demetrius Albanes, Lifang Hou, Polly A. Newcomb, Emily White, Alicja Wolk, Anna H. Wu, Loïc Le Marchand, Amanda I. Phipps, Daniel D. Buchanan, Sizheng Steven Zhao, Dipender Gill, Stephen J. Chanock, Mark P. Purdue, George Davey Smith, Paul Brennan, Karl-Heinz Herzig, Marjo-Riitta Järvelin, Chris I. Amos, Rayjean J. Hung, Abbas Dehghan, Mattias Johansson, Marc J. Gunter, Kostas K. Tsilidis, Richard M. Martin, Maria Teresa Landi, Victoria Stevens, Ying Wang, Demetrios Albanes, Neil Caporaso, Christopher I. Amos, Sanjay Shete, Heike Bickeböller, Angela Risch, Richard Houlston, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, H-Erich Wichmann, David Christiani, Gadi Rennert, Susanne Arnold, John K. Field, Loic Le Marchand, Olle Melander, Hans Brunnström, Geoffrey Liu, Angeline Andrew, Hongbing Shen, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, M. Dawn Teare, Yun-Chul Hong, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Rosalind A. Eeles, Christopher A. Haiman, Zsofia Kote-Jarai, Fredrick R. Schumacher, Sara Benlloch, Ali Amin Al Olama, Kenneth R. Muir, Sonja I. Berndt, David V. Conti, Fredrik Wiklund, Stephen Chanock, Catherine M. Tangen, Jyotsna Batra, Judith A. Clements, Henrik Grönberg, Nora Pashayan, Johanna Schleutker, Stephanie J. Weinstein, Catharine M.L. West, Lorelei A. Mucci, Géraldine Cancel-Tassin, Stella Koutros, Karina Dalsgaard Sørensen, Eli Marie Grindedal, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Ruth C. Travis, Robert J. Hamilton, Sue Ann Ingles, Barry S. Rosenstein, Yong-Jie Lu, Graham G. Giles, Robert J. MacInnis, Adam S. Kibel, Ana Vega, Manolis Kogevinas, Kathryn L. Penney, Jong Y. Park, Janet L. Stanfrod, Cezary Cybulski, Børge G. Nordestgaard, Sune F. Nielsen, Hermann Brenner, Christiane Maier, Christopher J. Logothetis, Esther M. John, Manuel R. Teixeira, Susan L. Neuhausen, Kim De Ruyck, Azad Razack, Lisa F. Newcomb, Davor Lessel, Radka Kaneva, Nawaid Usmani, Frank Claessens, Paul A. Townsend, Jose Esteban Castelao, Monique J. Roobol, Florence Menegaux, Kay-Tee Khaw, Lisa Cannon-Albright, Hardev Pandha, Stephen N. Thibodeau, David J. Hunter, Peter Kraft, William J. Blot, Elio Riboli

Publikováno v: EBioMedicine, Vol 100, Iss , Pp 104991- (2024)

Summary: Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, th

Externí odkaz: https://doaj.org/article/76559893532a492cbb3d1275b22f7ce4

An Integrative Pancreatic Cancer Risk Prediction Model in the UK Biobank

Autor: Te-Min Ke, Artitaya Lophatananon, Kenneth R. Muir

Publikováno v: Biomedicines, Vol 11, Iss 12, p 3206 (2023)

Pancreatic cancer (PaCa) is a lethal cancer with an increasing incidence, highlighting the need for early prevention strategies. There is a lack of a comprehensive PaCa predictive model derived from large prospective cohorts. Therefore, we have devel

Externí odkaz: https://doaj.org/article/d6dc8fdf271e416bb5239ae648deb5c7

Relationship of self-reported body size and shape with risk for prostate cancer: A UK case-control study.

Autor: Mohammad Aladwani, Artitaya Lophatananon, Fredie Robinson, Aneela Rahman, William Ollier, Zsofia Kote-Jarai, David Dearnaley, Govindasami Koveela, Nafisa Hussain, Reshma Rageevakumar, Diana Keating, Andrea Osborne, Tokhir Dadaev, Mark Brook, British Association of Urological Surgeons’ Section of Oncology, Rosalind Eeles, Kenneth R Muir

Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0238928 (2020)

IntroductionPrevious evidence has suggested a relationship between male self-reported body size and the risk of developing prostate cancer. In this UK-wide case-control study, we have explored the possible association of prostate cancer risk with mal

Externí odkaz: https://doaj.org/article/132a498f1ff04ae384aa7098c887df64