Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Kenneth N. Kreuzer"'
5-Azacytidine (aza-C) and its derivatives are cytidine analogues used for leukemia chemotherapy. The primary effect of aza-C is the prohibition of cytosine methylation, which results in covalent methyltransferase-DNA (MTase-DNA) adducts at cytosine m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fff534f6e3e726afbcef56e81d0fb36
https://doi.org/10.1158/0008-5472.c.6496527
https://doi.org/10.1158/0008-5472.c.6496527
Supplementary Figures 1-5 from 5-Azacytidine–Induced Methyltransferase-DNA Adducts Block DNA Replication In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cc24d8ec9beaedd71342f49c98f0cb
https://doi.org/10.1158/0008-5472.22370760.v1
https://doi.org/10.1158/0008-5472.22370760.v1
Autor:
Morgan L Henderson, Kenneth N Kreuzer
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128092 (2015)
Expression of mutant EcoRII methyltransferase protein (M.EcoRII-C186A) in Escherichia coli leads to tightly bound DNA-protein complexes (TBCs), located sporadically on the chromosome rather than in tandem arrays. The mechanisms behind the lethality i
Externí odkaz:
https://doaj.org/article/24a5acb5fe4c4a41ab6b44166a111cd8
Autor:
Zakiya N. Whatley, Kenneth N. Kreuzer
Publikováno v:
G3: Genes|Genomes|Genetics
The dnaQ gene of Escherichia coli encodes the ε subunit of DNA polymerase III, which provides the 3′ → 5′ exonuclease proofreading activity of the replicative polymerase. Prior studies have shown that loss of ε leads to high mutation frequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02652757a619b8a2a1e96b679e223d18
http://europepmc.org/articles/PMC4478557
http://europepmc.org/articles/PMC4478557
Publikováno v:
DNA Repair. 28:48-59
Pathways for tolerating and repairing DNA-protein crosslinks (DPCs) are poorly defined. We used transposon mutagenesis and candidate gene approaches to identify DPC-hypersensitive Escherichia coli mutants. DPCs were induced by azacytidine (aza-C) tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08b7936272bc261b8f1312d09c385ea
https://doi.org/10.1016/j.dnarep.2015.01.016
https://doi.org/10.1016/j.dnarep.2015.01.016
Publikováno v:
Molecular Microbiology. 91:39-56
DNA replication in Escherichia coli is normally initiated at a single origin, oriC, dependent on initiation protein DnaA. However, replication can be initiated elsewhere on the chromosome at multiple ectopic oriK sites. Genetic evidence indicates tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b689333b091a0e68cddbecd9b816a96
https://doi.org/10.1111/mmi.12440
https://doi.org/10.1111/mmi.12440
Publikováno v:
Molecular Microbiology. 78:686-700
Summary Anticancer drug 5-azacytidine (aza-C) induces DNA–protein cross-links (DPCs) between cytosine methyltransferase and DNA as the drug inhibits methylation. We found that mutants defective in the tmRNA translational quality control system are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aefeaf1d4963ed6141e7b21bc959b051
https://doi.org/10.1111/j.1365-2958.2010.07355.x
https://doi.org/10.1111/j.1365-2958.2010.07355.x
Publikováno v:
Journal of Biological Chemistry. 282:34401-34411
The phage T4 UvsW protein has been shown to play a crucial role in the switch from origin-dependent to recombination-dependent replication in T4 infections through the unwinding of origin R-loop initiation intermediates. UvsW also functions with UvsX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e098bc42f5a1f138558ac551d2f8a0e
https://doi.org/10.1074/jbc.m705913200
https://doi.org/10.1074/jbc.m705913200
Autor:
Bryanna R. Behning, Scott W. Nelson, Kenneth N. Kreuzer, Bradley A. Stohr, Yang Gao, Timothy J. Herdendorf, Tasida Barfoot
Publikováno v:
The Journal of biological chemistry, vol 290, iss 39
Rad50 and Mre11 form a complex involved in the detection and processing of DNA double strand breaks. Rad50 contains an anti-parallel coiled-coil with two absolutely conserved cysteine residues at its apex. These cysteine residues serve as a dimerizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454c80605006b52d06c41910d109727a
https://escholarship.org/uc/item/3sb3t8jk
https://escholarship.org/uc/item/3sb3t8jk