Source of Rate Acceleration for Carbocation Cyclization in Biomimetic Supramolecular Cages

Autor: Quynh Nhu N. Nguyen, Kay T. Xia, Yue Zhang, Nanhao Chen, Mariko Morimoto, Xiaokun Pei, Yang Ha, Jinghua Guo, Wanli Yang, Lee-Ping Wang, Robert G. Bergman, Kenneth N. Raymond, F. Dean Toste, Dean J. Tantillo

Publikováno v: Journal of the American Chemical Society. 144:11413-11424

The results of quantum chemical and molecular dynamics calculations reveal that polyanionic gallium-based cages accelerate cyclization reactions of pentadienyl alcohols as a result of substrate cage interactions, preferential binding of reactive conf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4bf0b8bac3831565f0d479da13e984
https://doi.org/10.1021/jacs.2c04179

Impact of Host Flexibility on Selectivity in a Supramolecular Host-Catalyzed Enantioselective aza-Darzens Reaction

Autor: Stephen M. Bierschenk, Judy Y. Pan, Nicholas S. Settineri, Ulrike Warzok, Robert G. Bergman, Kenneth N. Raymond, F. Dean Toste

Publikováno v: Journal of the American Chemical Society. 144(25)

A highly enantioselective aza-Darzens reaction (up to 99% ee) catalyzed by an enantiopure supramolecular host has been discovered. To understand the role of host structure on reaction outcome, nine new gallium(III)-based enantiopure supramolecular as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd69ace25fe58d4afd1a83cda3b33e02
https://pubmed.ncbi.nlm.nih.gov/35700232

Heterogeneous Supramolecular Catalysis through Immobilization of Anionic M4L6 Assemblies on Cationic Polymers

Autor: Robert G. Bergman, F. Dean Toste, Kenneth N. Raymond, Hiroyuki Miyamura

Publikováno v: Journal of the American Chemical Society. 142:19327-19338

Although most of the currently developed supramolecular catalysts that emulate enzymatic reactivity with unique selectivity and activity through specific host-guest interactions work under homogeneous conditions, enzymes in nature can operate under h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8891084a9f1826052065439ac855ddc
https://doi.org/10.1021/jacs.0c09556

An isolated water droplet in the aqueous solution of a supramolecular tetrahedral cage

Autor: Wan-Lu Li, Martina Havenith, Robert G. Bergman, F. Dean Toste, Trandon A. Bender, Simone Pezzotti, Teresa Head-Gordon, Kenneth N. Raymond, Federico Sebastiani, Gerhard Schwaab

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 52
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences

Significance Using a supramolecular assembly that catalyzes substrates in water, we show that the nanocage encapsulates a water cluster that is structurally and dynamically distinct from any known phase of water. It plays an important role in the dri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3efcb56c52d900a5720258ddef8c5383
https://escholarship.org/uc/item/0v12j36n

Siderocalin/Lcn2/NGAL/24p3 does not drive apoptosis through gentisic acid mediated iron withdrawal in hematopoietic cell lines.

Autor: Colin Correnti, Vera Richardson, Allyson K Sia, Ashok D Bandaranayake, Mario Ruiz, Yohan Suryo Rahmanto, Žaklina Kovačević, Matthew C Clifton, Margaret A Holmes, Brett K Kaiser, Jonathan Barasch, Kenneth N Raymond, Des R Richardson, Roland K Strong

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e43696 (2012)

Siderocalin (also lipocalin 2, NGAL or 24p3) binds iron as complexes with specific siderophores, which are low molecular weight, ferric ion-specific chelators. In innate immunity, siderocalin slows the growth of infecting bacteria by sequestering bac

Externí odkaz: https://doaj.org/article/0c7a60a30b9141c7948d0f013f4ece1f