Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Kenneth N Ross"'
Autor:
Felix Oppel, Ting Tao, Hui Shi, Kenneth N Ross, Mark W Zimmerman, Shuning He, Guangxiang Tong, Jon C Aster, A Thomas Look
Publikováno v:
PLoS Genetics, Vol 15, Iss 4, p e1008039 (2019)
The SWI/SNF-family chromatin remodeling protein ATRX is a tumor suppressor in sarcomas, gliomas and other malignancies. Its loss of function facilitates the alternative lengthening of telomeres (ALT) pathway in tumor cells, while it also affects Poly
Externí odkaz:
https://doaj.org/article/a406772986bc4045b55fe8516df75a33
Autor:
Laila Ritsma, Ipsita Dey-Guha, Nilesh Talele, Xavier Sole, Salony, Joeeta Chowdhury, Kenneth N Ross, Sridhar Ramaswamy
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175300 (2017)
TGF-β is a cytokine thought to function as a tumor promoter in advanced malignancies. In this setting, TGF-β increases cancer cell proliferation, survival, and migration, and orchestrates complex, pro-tumorigenic changes in the tumor microenvironme
Externí odkaz:
https://doaj.org/article/928f5505a3db4d31bd3f4df0c416ec6c
Autor:
Miguel Aste-Amézaga, Ningyan Zhang, Janet E Lineberger, Beth A Arnold, Timothy J Toner, Mingcheng Gu, Lingyi Huang, Salvatore Vitelli, Kim T Vo, Peter Haytko, Jing Zhang Zhao, Frederic Baleydier, Sarah L'Heureux, Hongfang Wang, Wendy R Gordon, Elizabeth Thoryk, Marie Blanke Andrawes, Kittichoat Tiyanont, Kimberly Stegmaier, Giovanni Roti, Kenneth N Ross, Laura L Franlin, Hui Wang, Fubao Wang, Michael Chastain, Andrew J Bett, Laurent P Audoly, Jon C Aster, Stephen C Blacklow, Hans E Huber
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9094 (2010)
Notch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms. On the other hand, dysregulation of Notch1 signaling is associated with many different types of cancer
Externí odkaz:
https://doaj.org/article/b4ac98e727c04ff3ad08212b68b47d08
Autor:
Kimberly Stegmaier, Jenny S Wong, Kenneth N Ross, Kwan T Chow, David Peck, Renee D Wright, Stephen L Lessnick, Andrew L Kung, Todd R Golub
Publikováno v:
PLoS Medicine, Vol 4, Iss 4, p e122 (2007)
The presence of tumor-specific mutations in the cancer genome represents a potential opportunity for pharmacologic intervention to therapeutic benefit. Unfortunately, many classes of oncoproteins (e.g., transcription factors) are not amenable to conv
Externí odkaz:
https://doaj.org/article/3348c2ae2b8649059a89ebaf6cc79b72
Autor:
Nathaniel W. Mabe, Min Huang, Guillermo N. Dalton, Gabriela Alexe, Daniel A. Schaefer, Anna C. Geraghty, Amanda L. Robichaud, Amy S. Conway, Delan Khalid, Marius M. Mader, Julia A. Belk, Kenneth N. Ross, Michal Sheffer, Miles H. Linde, Nghi Ly, Winnie Yao, Maria Caterina Rotiroti, Benjamin A. H. Smith, Marius Wernig, Carolyn R. Bertozzi, Michelle Monje, Constantine S. Mitsiades, Ravindra Majeti, Ansuman T. Satpathy, Kimberly Stegmaier, Robbie G. Majzner
Publikováno v:
Nature Cancer. 3:976-993
Immunotherapy with anti-GD2 antibodies has advanced the treatment of children with high-risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms of resistance to anti-GD2 therapy. Here, we show that reduced GD2 ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c9eabc77d406c8f3cf09781745ec5a
https://doi.org/10.1038/s43018-022-00405-x
https://doi.org/10.1038/s43018-022-00405-x
Autor:
Sridhar Ramaswamy, Kenneth N. Ross, Hege G. Russnes, Anne-Lise Borresen-Dale, Dennis Sgroi, Massimo Loda, Mari Mino-Kenudson, Joeeta Chowdhury, Xavier Solé, Nilesh P. Talele, Albert C. Yeh, Sheheryar Kabraji, Ipsita Dey-Guha, Cleidson P. Alves
Supp. Fig. 2. AKT1-WT versus AKT1-E17K: Functional assays in vitro (Part 1). Proliferation assays performed three days after induction of AKT1-WT or AKT1-E17K protein under normal fetal bovine serum (10%), low serum (1%), hypoxia (4% O2), and with pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11947d0f73d9860a6894097037c7d2b6
https://doi.org/10.1158/1535-7163.22504653.v1
https://doi.org/10.1158/1535-7163.22504653.v1
Autor:
Sridhar Ramaswamy, Kenneth N. Ross, Hege G. Russnes, Anne-Lise Borresen-Dale, Dennis Sgroi, Massimo Loda, Mari Mino-Kenudson, Joeeta Chowdhury, Xavier Solé, Nilesh P. Talele, Albert C. Yeh, Sheheryar Kabraji, Ipsita Dey-Guha, Cleidson P. Alves
Supp. Fig. 3. AKT1-WT versus AKT1-E17K: Functional assays in vitro (Part 2). Bar plots for functional assays performed three days after induction of AKT1-WT or AKT1-E17K protein for colony formation (on plastic), migration, invasion (in matrigel), co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b06e77c4de0fdc30169524ff9b62cf
https://doi.org/10.1158/1535-7163.22504647.v1
https://doi.org/10.1158/1535-7163.22504647.v1
Autor:
Sridhar Ramaswamy, Shobha Vasudevan, Wilhelm Haas, Kenneth N. Ross, Joeeta Chowdhury, Ju H. Lee, Myriam Boukhali, Laila Ritsma, Ipsita Dey-Guha, Cleidson P. Alves, Xavier Solé
Bioactivity and effect of microvesicles on growth rate using MK-2206 inhibitor in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1346add81c3795195f1a63c9222ff762
https://doi.org/10.1158/1535-7163.22504069
https://doi.org/10.1158/1535-7163.22504069
Autor:
Sridhar Ramaswamy, Kenneth N. Ross, Hege G. Russnes, Anne-Lise Borresen-Dale, Dennis Sgroi, Massimo Loda, Mari Mino-Kenudson, Joeeta Chowdhury, Xavier Solé, Nilesh P. Talele, Albert C. Yeh, Sheheryar Kabraji, Ipsita Dey-Guha, Cleidson P. Alves
Analysis of correlation between the presence of AKT1-E17K mutation and clinical aspects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405f9371f5f306cb771572c77c6f4aae
https://doi.org/10.1158/1535-7163.22504638
https://doi.org/10.1158/1535-7163.22504638
Autor:
Sridhar Ramaswamy, Kenneth N. Ross, Hege G. Russnes, Anne-Lise Borresen-Dale, Dennis Sgroi, Massimo Loda, Mari Mino-Kenudson, Joeeta Chowdhury, Xavier Solé, Nilesh P. Talele, Albert C. Yeh, Sheheryar Kabraji, Ipsita Dey-Guha, Cleidson P. Alves
Supp. Fig. 5. Sensitivity to Paclitaxel in AKT1-WT, AKT1-E17K xenographic tumors. Mice with subcutaneous (A) AKT1-WT or (B) AKT-E17K tumors were treated with paclitaxel. The ratio of treated and non-treated is shown in C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa1a682f89df17fd06c8774a79e61e4
https://doi.org/10.1158/1535-7163.22504641.v1
https://doi.org/10.1158/1535-7163.22504641.v1