Zobrazeno 1 - 10 of 77 pro vyhledávání: '"Kenneth Macleod"'
1
Akademický článek
Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment
Autor: John C. Dawson, Alison Munro, Kenneth Macleod, Morwenna Muir, Paul Timpson, Robert J. Williams, Margaret Frame, Valerie G. Brunton, Neil O. Carragher
Publikováno v: Molecular Oncology, Vol 16, Iss 5, Pp 1072-1090 (2022)
A more comprehensive understanding of how cells respond to drug intervention, the likely immediate signalling responses and how resistance may develop within different microenvironments will help inform treatment regimes. The nonreceptor tyrosine kin
Externí odkaz: https://doaj.org/article/fab8f61f00ef4132b7b597f9dca6a022
Zobrazit plný text záznamu
2
Akademický článek
Combined targeting of MEK and the glucocorticoid receptor for the treatment of RAS-mutant multiple myeloma
Autor: Priya Sriskandarajah, Alexis De Haven Brandon, Kenneth MacLeod, Neil O. Carragher, Vladimir Kirkin, Martin Kaiser, Steven R. Whittaker
Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
Abstract Background Multiple myeloma (MM) remains incurable despite recent therapeutic advances. RAS mutations are frequently associated with relapsed/refractory disease. Efforts to target the mitogen-activated protein kinase (MAPK) pathway with the
Externí odkaz: https://doaj.org/article/87d98533f87749f780cf3deed309028f
Zobrazit plný text záznamu
3
Akademický článek
TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p
Autor: Jonathan Berrout, Eleni Kyriakopoulou, Lavanya Moparthi, Alexandra S. Hogea, Liza Berrout, Cristina Ivan, Mihaela Lorger, John Boyle, Chris Peers, Stephen Muench, Jacobo Elies Gomez, Xin Hu, Carolyn Hurst, Thomas Hall, Sujanitha Umamaheswaran, Laura Wesley, Mihai Gagea, Michael Shires, Iain Manfield, Margaret A. Knowles, Simon Davies, Klaus Suhling, Yurema Teijeiro Gonzalez, Neil Carragher, Kenneth Macleod, N. Joan Abbott, George A. Calin, Nikita Gamper, Peter M. Zygmunt, Zahra Timsah
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
TRPA1 has been reported to contribute lung cancer adenocarcinoma (LUAD), but the mechanisms are unclear. Here the authors propose that TRPA1/FGFR2 interaction is functional in LUAD and show that astrocytes oppose brain metastasis by mediating the dow
Externí odkaz: https://doaj.org/article/33513ba93d3143cf9c9bd5f381eb5965
Zobrazit plný text záznamu
4
Akademický článek
Enhanced photoacoustic gas analyser response time and impact on accuracy at fast ventilation rates during multiple breath washout.
Autor: Alex Horsley, Kenneth Macleod, Ruchi Gupta, Nick Goddard, Nicholas Bell
Publikováno v: PLoS ONE, Vol 9, Iss 6, p e98487 (2014)
The Innocor device contains a highly sensitive photoacoustic gas analyser that has been used to perform multiple breath washout (MBW) measurements using very low concentrations of the tracer gas SF6. Use in smaller subjects has been restricted by the
Externí odkaz: https://doaj.org/article/3995d5cec45744cbb489360d0ec614df
Zobrazit plný text záznamu
5
Supplementary from Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy
Autor: C. Roland Wolf, Colin J. Henderson, Lesley A. McLaughlin, Jeffrey T.–J. Huang, De Lin, A. Kenneth MacLeod
Supplementary Table 1: MRM parameters for osimertinib, metabolites and internal standard. Supplementary Table 2. Correlation coefficients for formation of osimertinib metabolites. Supplementary Table 3. Metabolic phenotyping of osimertinib in pooled
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2950936f04be3c883cf87f0289c278
https://doi.org/10.1158/1078-0432.22469784.v1
Zobrazit plný text záznamu
6
Data from Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy
Autor: C. Roland Wolf, Colin J. Henderson, Lesley A. McLaughlin, Jeffrey T.–J. Huang, De Lin, A. Kenneth MacLeod
Purpose: Osimertinib is a third-generation inhibitor of the epidermal growth factor receptor used in treatment of non–small cell lung cancer. A full understanding of its disposition and capacity for interaction with other medications will facilitat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de38d1349080112b5823ed687534a03
https://doi.org/10.1158/1078-0432.c.6527346.v1
Zobrazit plný text záznamu
10
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje