Zobrazeno 1 - 10
of 357
pro vyhledávání: '"Kenneth M. Rosen"'
Autor:
Sarah A. Woller, Joerg Ruschel, Barbara Morquette, James Cardia, Dinxue Yan, Katherine Holton, Taisia Shmushkovich, Emily Niederst, Karen Bulock, Alexey Wolfson, Matthew Abbinanti, Alyson E. Fournier, Lisa McKerracher, Kenneth M. Rosen
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104379- (2022)
Summary: The therapeutic use of RNAi has grown but often faces several hurdles related to delivery systems, compound stability, immune activation, and on-target/off-tissue effects. Self-delivering RNAi (sdRNA) molecules do not require delivery agents
Externí odkaz:
https://doaj.org/article/ac37080eac5e4e00b5d86c3ffc8224e3
Autor:
Lisa eMcKerracher, Kenneth M Rosen
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 8 (2015)
While neurons in the central nervous system have the capacity to regenerate their axons after injury, they fail to do so, in part because regeneration is limited by growth inhibitory proteins present in CNS myelin. Myelin-associated glycoprotein (MAG
Externí odkaz:
https://doaj.org/article/a905152f42f845e9bc6f83f3aef90fae
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2015)
While neurons have long been considered the major player in multiple brain functions such as perception, emotion and memory, glial cells have been relegated to a far lesser position, acting as merely a glue to support neurons. Multiple lines of recen
Externí odkaz:
https://doaj.org/article/bea2d387606a4a3ea9852dee0cceac0b
Autor:
Janne Koskimäki, Thomas R. Moore, Nicholas Hobson, Amy Peiper, Rhonda Lightle, James K. Liao, Issam A. Awad, Robert Shenkar, Kenneth M. Rosen, Douglas A. Marchuk, Joerg Ruschel, Ying Cao, Lisa McKerracher, Romuald Girard, Matthew D. Abbinanti, Carol J. Gallione
Publikováno v:
Transl Stroke Res
Cavernous angioma (CA) is a vascular pathology caused by loss of function in one of the 3 CA genes (CCM1, CCM2, and CCM3) that result in rho kinase (ROCK) activation. We investigated a novel ROCK2 selective inhibitor for the ability to reduce brain l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb09a43d18645df4f1a6091c55029a8
https://doi.org/10.1007/s12975-019-00725-8
https://doi.org/10.1007/s12975-019-00725-8
Autor:
Sarah A. Woller, Joerg Ruschel, Barbara Morquette, James Cardia, Dinxue Yan, Katherine Holton, Taisia Shmushkovich, Emily Niederst, Karen Bulock, Alexey Wolfson, Matthew Abbinanti, Alyson E. Fournier, Lisa McKerracher, Kenneth M. Rosen
Publikováno v:
iScience. 25(6)
The therapeutic use of RNAi has grown but often faces several hurdles related to delivery systems, compound stability, immune activation, and on-target/off-tissue effects. Self-delivering RNAi (sdRNA) molecules do not require delivery agents or excip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0ec2aff67a81cdb6819da9bafbc234
https://pubmed.ncbi.nlm.nih.gov/35620420
https://pubmed.ncbi.nlm.nih.gov/35620420
Autor:
Pin Xu, Kristian Hedstrom, Sushovan Guha, Courtney Hart, Kenneth M. Rosen, Osvaldo Rey, Gabriel Corfas
Publikováno v:
Glia. 61:1029-1040
Upon peripheral nerve injury, specific molecular events, including increases in the expression of selected neurotrophic factors, are initiated to prepare the tissue for regeneration. However, the mechanisms underlying these events and the nature of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9e2cba81b28a9b91d277de1f6e60fe6
https://doi.org/10.1002/glia.22491
https://doi.org/10.1002/glia.22491
Publikováno v:
Science. 337:1357-1360
A Critical Period for Glia The brain develops in fits and starts—while one system is completed, another system may still be under construction. Such transient states are known as critical periods, and during these specific aspects of brain developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2c09e773b74b8daa6c831c307708d2
https://doi.org/10.1126/science.1220845
https://doi.org/10.1126/science.1220845
Autor:
J. Gordon Leishman, Kenneth M. Rosen
Publikováno v:
Journal of the American Helicopter Society. 56:12004-1200421
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e614e18b90c04f6dee60a49735ecb05
https://doi.org/10.4050/jahs.56.012004
https://doi.org/10.4050/jahs.56.012004
Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function
Autor:
Henry W. Querfurth, Pravir Kumar, Gangjian Qin, Han-Kyu Lee, Qinghao Fu, Charbel Moussa, Tohru Kitada, Kenneth M. Rosen
Publikováno v:
Journal of Neuroscience Research. 88:167-178
The significance of intracellular beta-amyloid (Abeta(42)) accumulation is increasingly recognized in Alzheimer's disease (AD) pathogenesis. Abeta removal mechanisms that have attracted attention include IDE/neprilysin degradation and antibody-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::457326bec546c570f8b669a8f8cddea4
https://doi.org/10.1002/jnr.22178
https://doi.org/10.1002/jnr.22178
Autor:
Kenneth M. Rosen, Pravir Kumar, Ken Kosik, Vimal Veereshwarayya, Cam Patterson, Rashmi K. Ambasta, Hamid Band, Ruben Mestril, Henry W. Querfurth
Publikováno v:
Human Molecular Genetics. 16:848-864
The C-terminus Hsp70 interacting protein (CHIP) has dual function as both co-chaperone and ubiquitin ligase. CHIP is increasingly implicated in the biology of polyglutamine expansion disorders, Parkinson's disease and tau protein in Alzheimer's disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186a388b216ba15599b2f751b32ce1fb
https://doi.org/10.1093/hmg/ddm030
https://doi.org/10.1093/hmg/ddm030