Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Kenneth M. Kaufman"'
Autor:
Kenyatta C. M. F. Viel, Sreeja Parameswaran, Omer A. Donmez, Carmy R. Forney, Matthew R. Hass, Cailing Yin, Sydney H. Jones, Hayley K. Prosser, Arame A. Diouf, Olivia E. Gittens, Lee E. Edsall, Xiaoting Chen, Hope Rowden, Katelyn A. Dunn, Rui Guo, Andrew VonHandorf, Merrin Man Long Leong, Kevin Ernst, Kenneth M. Kaufman, Lucinda P. Lawson, Ben Gewurz, Bo Zhao, Leah C. Kottyan, Matthew T. Weirauch
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Background There are two major genetic types of Epstein-Barr Virus (EBV): type 1 (EBV-1) and type 2 (EBV-2). EBV functions by manipulating gene expression in host B cells, using virus-encoded gene regulatory proteins including Epstein-Barr N
Externí odkaz:
https://doaj.org/article/155fc47c06e74fd5b11dee66241b344d
Autor:
Tian Zhou, Xinyi Zhu, Zhizhong Ye, Yong-Fei Wang, Chao Yao, Ning Xu, Mi Zhou, Jianyang Ma, Yuting Qin, Yiwei Shen, Yuanjia Tang, Zhihua Yin, Hong Xu, Yutong Zhang, Xiaoli Zang, Huihua Ding, Wanling Yang, Ya Guo, John B. Harley, Bahram Namjou, Kenneth M. Kaufman, Leah C. Kottyan, Matthew T. Weirauch, Guojun Hou, Nan Shen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The functional effects of genetic loci associated with autoimmune disease are not well understood. By dissecting an autoimmune disease genetic locus, the authors define an immune cell-type-specific enhancer and the molecular mechanisms underlying the
Externí odkaz:
https://doaj.org/article/b834bed781e544609a560d62e4f3795e
Autor:
Tetsuo Shoda, Kenneth M. Kaufman, Ting Wen, Julie M. Caldwell, Garrett A. Osswald, Pathre Purnima, Nives Zimmermann, Margaret H. Collins, Kira Rehn, Heather Foote, Michael D. Eby, Wenying Zhang, Netali Ben-Baruch Morgenstern, Adina Y. Ballaban, Jeff E. Habel, Leah C. Kottyan, J. Pablo Abonia, Vincent A. Mukkada, Philip E. Putnam, Lisa J. Martin, Marc E. Rothenberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory disease with a complex underlying genetic etiology. Here, the authors identify a series of rare variants in DSP and PPL in multiplex families with EoE and uncover a pathogenic role for
Externí odkaz:
https://doaj.org/article/f2e541c35dcb4834913ac2dfae852b00
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundThat Epstein–Barr virus (EBV) infection is associated with systemic lupus erythematosus (SLE) is established. The challenge is to explain mechanistic roles EBV has in SLE pathogenesis. Previous studies identify four examples of autoantibo
Externí odkaz:
https://doaj.org/article/83e03f9f973c4f39a4fe6aa357ab1345
Autor:
Carl D. Langefeld, Hannah C. Ainsworth, Deborah S. Cunninghame Graham, Jennifer A. Kelly, Mary E. Comeau, Miranda C. Marion, Timothy D. Howard, Paula S. Ramos, Jennifer A. Croker, David L. Morris, Johanna K. Sandling, Jonas Carlsson Almlöf, Eduardo M. Acevedo-Vásquez, Graciela S. Alarcón, Alejandra M. Babini, Vicente Baca, Anders A. Bengtsson, Guillermo A. Berbotto, Marc Bijl, Elizabeth E. Brown, Hermine I. Brunner, Mario H. Cardiel, Luis Catoggio, Ricard Cervera, Jorge M. Cucho-Venegas, Solbritt Rantapää Dahlqvist, Sandra D’Alfonso, Berta Martins Da Silva, Iñigo de la Rúa Figueroa, Andrea Doria, Jeffrey C. Edberg, Emőke Endreffy, Jorge A. Esquivel-Valerio, Paul R. Fortin, Barry I. Freedman, Johan Frostegård, Mercedes A. García, Ignacio García de la Torre, Gary S. Gilkeson, Dafna D. Gladman, Iva Gunnarsson, Joel M. Guthridge, Jennifer L. Huggins, Judith A. James, Cees G. M. Kallenberg, Diane L. Kamen, David R. Karp, Kenneth M. Kaufman, Leah C. Kottyan, László Kovács, Helle Laustrup, Bernard R. Lauwerys, Quan-Zhen Li, Marco A. Maradiaga-Ceceña, Javier Martín, Joseph M. McCune, David R. McWilliams, Joan T. Merrill, Pedro Miranda, José F. Moctezuma, Swapan K. Nath, Timothy B. Niewold, Lorena Orozco, Norberto Ortego-Centeno, Michelle Petri, Christian A. Pineau, Bernardo A. Pons-Estel, Janet Pope, Prithvi Raj, Rosalind Ramsey-Goldman, John D. Reveille, Laurie P. Russell, José M. Sabio, Carlos A. Aguilar-Salinas, Hugo R. Scherbarth, Raffaella Scorza, Michael F. Seldin, Christopher Sjöwall, Elisabet Svenungsson, Susan D. Thompson, Sergio M. A. Toloza, Lennart Truedsson, Teresa Tusié-Luna, Carlos Vasconcelos, Luis M. Vilá, Daniel J. Wallace, Michael H. Weisman, Joan E. Wither, Tushar Bhangale, Jorge R. Oksenberg, John D. Rioux, Peter K. Gregersen, Ann-Christine Syvänen, Lars Rönnblom, Lindsey A. Criswell, Chaim O. Jacob, Kathy L. Sivils, Betty P. Tsao, Laura E. Schanberg, Timothy W. Behrens, Earl D. Silverman, Marta E. Alarcón-Riquelme, Robert P. Kimberly, John B. Harley, Edward K. Wakeland, Robert R. Graham, Patrick M. Gaffney, Timothy J. Vyse
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hyp
Externí odkaz:
https://doaj.org/article/a68227bc3ba0457486591e4743061bf9
Autor:
C. Alexander Valencia, Ammar eHusami, Jennifer eHolle, Judith A. Johnson, Yaping eQian, Abhinav eMathur, Chao eWei, Subba Rao Indugula, Fanggeng eZou, Haiying eMeng, Lijun eWang, Xia eLi, Rachel eFisher, Tony eTan, Amber eHogart Begtrup, Kathleen eCollins, Katie A. Wusik, Derek eNeilson, Thomas eBurrow, Elizabeth eSchorry, Robert eHopkin, Mehdi eKeddache, John Barker Harley, Kenneth M. Kaufman, Kejian eZhang
Publikováno v:
Frontiers in Pediatrics, Vol 3 (2015)
Background: There are limited reports of the use of whole exome sequencing as a clinical diagnostic tool. Moreover, there are no reports addressing the cost burden associated with genetic tests performed prior to WES.Objective: We demonstrate the per
Externí odkaz:
https://doaj.org/article/47f746bdc4f4487bbc8ae264e42ce98b
Autor:
Samuel E. Vaughn, Corinne eFoley, Xiaoming eLu, Zubin Hasmukh Patel, Erin E. Zoller, Albert F. Magnusen, Adrienne H. Williams, Julie T. Ziegler, Mary E. Comeau, Miranda C. Marion, Stuart B. Glenn, Adam eAdler, Nan eShen, Swapan eNath, Anne M Stevens, Barry I. Freedman, Betty P. Tsao, Chaim O. Jacob, Diane L Kamen, Elizabeth E Brown, Gary S. Gilkeson, Graciela S. Alarcón, John D. Reveille, Juan-Manuel eAnaya, Judith A. James, Kathy L. Moser, Lindsey A. Criswell, Luis M. Vilá, Marta E. Alarcon-Riquelme, Michelle ePetri, R. Hal Scofield, Robert P. Kimberly, Rosalind eRamsey-Goldman, Young eBinjoo, Jeongim eChoi, Sang-Cheol eBae, Susan A. Boackle, Timothy J. Vyse, Joel M. Guthridge, Bahram eNamjou, Patrick M. Gaffney, Carl D. Langefeld, Kenneth M. Kaufman, Jennifer A Kelly, Isaac TW Harley, John Barker Harley, Leah Claire Kottyan
Publikováno v:
Frontiers in Genetics, Vol 5 (2015)
Genome wide association studies have identified variants in PXK that confer risk for humoral autoimmune diseases, including systemic lupus erythematosus (SLE) or lupus, rheumatoid arthritis and more recently systemic sclerosis. While PXK is involved
Externí odkaz:
https://doaj.org/article/5e75c958d69d4a42bd598e149c6574ec
Autor:
Indra Adrianto, Chee Paul Lin, Jessica J. Hale, Albert M. Levin, Indrani Datta, Ryan Parker, Adam Adler, Jennifer A. Kelly, Kenneth M. Kaufman, Christopher J. Lessard, Kathy L. Moser, Robert P. Kimberly, John B. Harley, Michael C. Iannuzzi, Benjamin A. Rybicki, Courtney G. Montgomery
Publikováno v:
PLoS ONE, Vol 8, Iss 9 (2013)
Externí odkaz:
https://doaj.org/article/9009949168f7479184ff4cb35fc8cfc4
Autor:
Isaac TW Harley, Celi Sun, Adrienne H Williams, Julie T Ziegler, Mary E Comeau, Miranda C Marion, Stuart B Glenn, Adam Adler, Summer G Frank-Pearce, Nan Shen, Jennifer A Kelly, Bahram Namjou-Khales, Michelle Petri, Marta Alarcon-Riquelme, W Joseph McCune, Patrick Gaffney, Kathy Sivils, Jane E Salmon, Michael H Weisman, Jeffrey C Edberg, Elizabeth E Brown, Tammy Utset, Lindsey A Criswell, Chaim O Jacob, Betty Tsao, Timothy J Vyse, Judith A James, Gary S Gilkeson, Diane L Kamen, Courtney Montgomery, Joan T Merrill, Swapan K Nath, Viktoryia Laurynenka, Iouri Chepelev, Valerie Harris-Lewis, R Hal Scofield, Robert P Kimberly, Carl D Langefeld, John B Harley, Kenneth M Kaufman
Publikováno v:
SLE Genetics.
Autor:
John B Harley, Saiju Pyarajan, Elizabeth S Partan, Lauren Epstein, Jason A Wertheim, Abhinav Diwan, Christopher W Woods, Victoria Davey, Sharlene Blair, Dennis H Clark, Kenneth M Kaufman, Shagufta Khan, Iouri Chepelev, Alexander Devine, Perry Cameron, Monica F McCann, Mary Cloud B Ammons, Devin D Bolz, Jane K Battles, Jeffrey L Curtis, Mark Holodniy, Vincent C Marconi, Charles D Searles, David O Beenhouwer, Sheldon T Brown, Jonathan P Moorman, Zhi Q Yao, Maria C Rodriguez-Barradas, Shyam Mohapatra, Osmara Y Molina De Rodriguez, Emerson B Padiernos, Eric R McIndoo, Emily Price, Hailey M Burgoyne, Ian Robey, Dawn C Schwenke, Carey L Shive, Ronald M Przygodzki, Rachel B Ramoni, Holly K Krull, Robert A Bonomo
Publikováno v:
Open Forum Infectious Diseases. 9
Background The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has demonstrated the need to share data and biospecimens broadly to optimize clinical outcomes for US military Ve