Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kenneth M. Borthwick"'
Autor:
Jonathan D. Mosley, QiPing Feng, Quinn S. Wells, Sara L. Van Driest, Christian M. Shaffer, Todd L. Edwards, Lisa Bastarache, Wei-Qi Wei, Lea K. Davis, Catherine A. McCarty, Will Thompson, Christopher G. Chute, Gail P. Jarvik, Adam S. Gordon, Melody R. Palmer, David R. Crosslin, Eric B. Larson, David S. Carrell, Iftikhar J. Kullo, Jennifer A. Pacheco, Peggy L. Peissig, Murray H. Brilliant, James G. Linneman, Bahram Namjou, Marc S. Williams, Marylyn D. Ritchie, Kenneth M. Borthwick, Shefali S. Verma, Jason H. Karnes, Scott T. Weiss, Thomas J. Wang, C. Michael Stein, Josh C. Denny, Dan M. Roden
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Biomarker identification requires prohibitively large cohorts with gene expression and phenotype data. The approach introduced here learns polygenic predictors of expression from genetic and expression data, used to infer biomarker levels in patients
Externí odkaz:
https://doaj.org/article/f49b8a4e08894b7bab01494933978a43
Autor:
Kathryn L. Jackson, Michael Mbagwu, Jennifer A. Pacheco, Abigail S. Baldridge, Daniel J. Viox, James G. Linneman, Sanjay K. Shukla, Peggy L. Peissig, Kenneth M. Borthwick, David A. Carrell, Suzette J. Bielinski, Jacqueline C. Kirby, Joshua C. Denny, Frank D. Mentch, Lyam M. Vazquez, Laura J. Rasmussen-Torvik, Abel N. Kho
Publikováno v:
BMC Infectious Diseases, Vol 16, Iss 1, Pp 1-7 (2016)
Abstract Background Community associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is one of the most common causes of skin and soft tissue infections in the United States, and a variety of genetic host factors are suspected to be risk fa
Externí odkaz:
https://doaj.org/article/4d221b043ca74636bd5c1786c9603d92
Autor:
Yoonjung Yoonie Joo, Jennifer A Pacheco, William K Thompson, Laura J Rasmussen-Torvik, Luke V Rasmussen, Frederick T J Lin, Mariza de Andrade, Kenneth M Borthwick, Erwin Bottinger, Andrew Cagan, David S Carrell, Joshua C Denny, Stephen B Ellis, Omri Gottesman, James G Linneman, Jyotishman Pathak, Peggy L Peissig, Ning Shang, Gerard Tromp, Annapoorani Veerappan, Maureen E Smith, Rex L Chisholm, Andrew J Gawron, M Geoffrey Hayes, Abel N Kho
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0283553 (2023)
ObjectiveDiverticular disease (DD) is one of the most prevalent conditions encountered by gastroenterologists, affecting ~50% of Americans before the age of 60. Our aim was to identify genetic risk variants and clinical phenotypes associated with DD,
Externí odkaz:
https://doaj.org/article/78f28682110648cfbe41e76d4bf5e28c
Autor:
Stephen F. Derose, Allan I. Pack, Timothy I. Morgenthaler, John C. Feemster, Kenneth M. Borthwick, Thomas R. Gossard, Beth A. Malow, Janet D. Robishaw, Maged Gendy, Phyllis C. Zee, Olivia J. Veatch, Luke N. Teigen, Brendan T. Keenan, Paul C. Timm, Laura Sirikulvadhana, Frances M. Pack, H. Lester Kirchner, Vicki A. Davenport
Publikováno v:
Journal of Clinical Sleep Medicine. 16:175-183
We examined the performance of a simple algorithm to accurately distinguish cases of diagnosed obstructive sleep apnea (OSA) and noncases using the electronic health record (EHR) across six health systems in the United States.Retrospective analysis o
Autor:
Ian B. Stanaway, Dan M. Roden, Divya Kalra, Dustin Key, Debra J. Abrams, David Fasel, Victor Castro, Brad Malin, Berta Almoguera, Beenish Riza, Meckenzie A. Behr, Eric Venner, Christine M. Eng, Joy Jayaseelan, Scott J. Hebbring, Michelle L. McGowan, Steven E. Scherer, Theresa L. Walunas, Mark Bowser, James D. Ralston, Wei-Qi Wei, Liwen Wang, David R. Murdock, Wayne H. Liang, Julia Wynn, Nancy D. Leslie, Laura J. Rasmussen-Torvik, Ming Ta (Michael) Lee, Frank D. Mentch, Lan Zhang, Alanna Kulchak Rahm, Josh F. Peterson, Jodell E. Linder, Joshua C. Smith, Soumitra Sengupta, Brendan J. Keating, Gina Vicente, Andrew Carroll, Nora B. Henrikson, Anne E. Justice, Heather S. Hain, Wen Liu, Andrea H. Ramirez, Matthew S. Lebo, Hana Zouk, Georgia L. Wiesner, Andrea L. Hartzler, Cassandra J. Pisieczko, Catherine M. Rives, Jessica Goehringer, Maegan V. Harden, John Lynch, Chiao-Feng Lin, Peter White, Phil Dunlea, Shawn N. Murphy, Mullai Murugan, Harshad Mahadeshwar, Mark Fleharty, Andrea Foster, Arvind Ramaprasan, Christopher A. Friedrich, Justin H. Gundelach, Hayley Lyon, Niall J. Lennon, Eric W. Klee, David R. Crosslin, Ge Zhang, Rongling Li, Ozan Dikilitas, Xiuping Liu, Christin Hoell, Aniwaa Owusu Obeng, Katherine D. Crew, Lisa M. Castillo, Justin Starren, Jonathan D. Mosley, Carrie L. Blout, Himanshu Sharma, Elizabeth M. McNally, Sarah T. Bland, Megan J. Puckelwartz, Matthew Varugheese, Keith Marsolo, Betty Woolf, Sharon Aufox, Janet L. Williams, Kimberly Walker, Murray H. Brilliant, Birgit Funke, Laura Allison Woods, Marylyn D. Ritchie, Brittany City, Todd Lingren, Hila Milo Rasouly, Lawrence J. Babb, Alex Fedotov, Robert C. Onofrio, Margaret Harr, Suzette J. Bielinski, Michael W. Wilson, Shubhabrata Mukherjee, Robert R. Freimuth, Chet Graham, Todd L. Edwards, Quinn S. Wells, Marc S. Williams, Jordan W. Smoller, Wendy K. Chung, Avni Santani, Paul K. Crane, George Hripcsak, QiPing Feng, Ali G. Gharavi, Yizhao Ni, Iftikhar J. Kullo, Michael Wagner, Philip E. Lammers, Michael J. Dinsmore, Thomas N. Person, Victoria Yi, Samuel E. Adunyah, Tim DeSmet, Eric B. Larson, Elizabeth Hynes, David C. Kochan, Eimear E. Kenny, Magalie S. Leduc, Lisa Mahanta, David Carrell, Paul S. Appelbaum, Viktoriya Korchina, Beth L. Cobb, Lynn Petukhova, Jessica De la Cruz, Patrick M. A. Sleiman, Stuart A. Scott, Tsung-Jung Wu, Gail P. Jarvik, Erwin P. Bottinger, Ken Wiley, Josh C. Denny, Melissa A. Basford, Samuel J. Aronson, David L. Veenstra, Yaping Yang, Kayla Marie Howell, John J. Connolly, Jessica Su, Yoonjung Yoonie Joo, Miguel Verbitsky, Sean M. Vargas, Cong Liu, Barbara Benoit, Andrew Hershey, Richard A. Gibbs, Cynthia A. Prows, Hana Bangash, Wendy Brodeur, Gauthami Chandanavelli, Sara L. Van Driest, Kurt D. Christensen, Elizabeth J. Bhoj, Vivian S. Gainer, Adam S. Gordon, Robert C. Green, Hakon Hakonarson, Krzysztof Kiryluk, Elisabeth A. Rosenthal, Rajbir Singh, James G. Linneman, Harrison Brand, Theodore Chiang, Sheila Dodge, Ingrid A. Holm, M. Geoffrey Hayes, Yunyun Jiang, Ning Shang, Samantha Baxter, Noralane M. Lindor, Kathleen A. Leppig, Teri A. Manolio, Sara E. Kalla, Pedro J. Caraballo, Ritika Raj, Aaron Scrol, Jyoti G. Dayal, Richard R. Sharp, Christie Kovar, Soumya Raychaudhuri, Sunghwan Sohn, Emily Kudalkar, Maddalena Marasa, Stacey Gabriel, Dan Schaid, Ladia Albertson-Junkans, Rex L. Chisholm, Maureen E. Smith, Donna M. Muzny, Casey Overby Taylor, Jianhong Hu, Elizabeth W. Karlson, Lisa Bastarache, Darren C. Ames, Joseph T. Glessner, Leora Witkowski, Siddharth Pratap, Qiaoyan Wang, Melissa A. Kelly, Adithya Balasubramanian, Kara Slowik, Terrie Kitchner, Barbara J. Klanderman, Shawn Denson, Mary Stroud, Alyssa Macbeth, Melanie F. Myers, Jesse Muniz, Kasia Tolwinski, Scott T. Weiss, Chunhua Weng, Stephanie M. Fullerton, John B. Harley, Christopher G. Chute, Heidi L. Rehm, Sheethal Jose, Andrew M. Glazer, Navya Shilpa Josyula, Kenneth M. Borthwick, Thomas E. Mullen, Mariza de Andrade, Leah C. Kottyan, Luke V. Rasmussen, James Meldrim, Bahram Namjou
Publikováno v:
The American Journal of Human Genetics. 105:588-605
The advancement of precision medicine requires new methods to coordinate and deliver genetic data from heterogeneous sources to physicians and patients. The eMERGE III Network enrolled >25,000 participants from biobank and prospective cohorts of pred
Autor:
Omri Gottesman, Frederick T.J. Lin, James G. Linneman, Mariza de Andrade, Luke V. Rasmussen, Rex L. Chisholm, Joshua C. Denny, Annapoorani Veerappan, Gerard Tromp, Laura J. Rasmussen-Torvik, Kenneth M. Borthwick, Andrew Cagan, Peggy L. Peissig, Jyotishman Pathak, M. Geoffrey Hayes, Ning Shang Shang, Erwin P. Bottinger, William K. Thompson, Jennifer A. Pacheco, Stephen B. Ellis, Andrew J. Gawron, Maureen E. Smith, Yoonjung Yoonie Joo, David Carrell, Abel N. Kho
Background and aimsDiverticular disease is among the most prevalent conditions encountered by gastroenterologists, affecting ∼50% of Americans before the age of 60. Our aim was to identify genetic risk variants and clinical phenotypes associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e08c4c98f1159a3e13441ba2cf0f8b08
https://doi.org/10.1101/2020.06.08.138735
https://doi.org/10.1101/2020.06.08.138735
Autor:
Dan M. Roden, Thomas J. Wang, Quinn S. Wells, Murray H. Brilliant, David R. Crosslin, Eric B. Larson, Catherine A. McCarty, Gail P. Jarvik, Iftikhar J. Kullo, Jennifer A. Pacheco, Todd L. Edwards, Christopher G. Chute, Marylyn D. Ritchie, Lisa Bastarache, Melody R. Palmer, Kenneth M. Borthwick, Jonathan D. Mosley, Bahram Namjou, Sara L. Van Driest, Wei-Qi Wei, Adam S. Gordon, Jason H. Karnes, Scott T. Weiss, C. Michael Stein, Peggy L. Peissig, Lea K. Davis, Christian M. Shaffer, QiPing Feng, David Carrell, Josh C. Denny, William K. Thompson, Shefali S. Verma, Marc S. Williams, James G. Linneman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications
Defining the full spectrum of human disease associated with a biomarker is necessary to advance the biomarker into clinical practice. We hypothesize that associating biomarker measurements with electronic health record (EHR) populations based on shar
Autor:
Peggy L. Peissig, Adam S. Gordon, Jacklyn N. Hellwege, Sarah C. Stallings, Murray H. Brilliant, Ning Shang, James G. Linneman, Hakon Hakonarson, David R. Crosslin, Eric S. Torstenson, Digna R. Velez Edwards, Shefali S. Verma, Todd L. Edwards, Kenneth M. Borthwick, George Hripcsak, Gail P. Jarvik, Josh C. Denny, Marylyn D. Ritchie, Robert J. Carroll, P. Sleiman, Dan M. Roden, Parimala Devi
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Benign prostatic hyperplasia (BPH) results in a significant public health burden due to the morbidity caused by the disease and many of the available remedies. As much as 70% of men over 70 will develop BPH. Few studies have been conducted to discove
Autor:
Patrick M. A. Sleiman, Eric B. Larson, Mark D. Benson, Marylyn D. Ritchie, Iftikhar J. Kullo, Kenneth M. Borthwick, Adam S. Gordon, Robert E. Gerszten, James G. Linneman, Gail P. Jarvik, David R. Crosslin, Frank D. Mentch, Dan M. Roden, Catherine A. McCarty, Yineng Zhu, Qiong Yang, Krzysztof Kiryluk, Josh C. Denny, Christopher G. Chute, David Carrell, Peggy L. Peissig, J. Gustav Smith, Bahram Namjou, Shefali S. Verma, Jane F. Ferguson, Marc S. Williams, Jennifer A. Pacheco, Debby Ngo, Terrie Kitchner, Christian M. Shaffer, Ramachandran S. Vasan, Melody R. Palmer, Elizabeth W. Karlson, Jonathan D. Mosley, Murray H. Brilliant, Thomas J. Wang, Olle Melander, Matthew Herzig
Publikováno v:
Circulation
Background: Proteomic approaches allow measurement of thousands of proteins in a single specimen, which can accelerate biomarker discovery. However, applying these technologies to massive biobanks is not currently feasible because of the practical ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982c7cf07e12272d2623badcc2b7f695
https://europepmc.org/articles/PMC8833190/
https://europepmc.org/articles/PMC8833190/
Autor:
Kenneth M. Borthwick, Paul A. Harris, Guoqian Jiang, David Carrell, Cosmin Adrian Bejan, Jennifer A. Pacheco, Yizhao Ni, Dan M. Roden, Firas Wehbe, Joshua C. Denny, Luke V. Rasmussen, Christopher G. Chute, Todd Lingren, Peggy L. Peissig, Huan Mo, Qian Zhu, Terrie Kitchner, Peter Speltz, Marc S. Williams, Enid Montague, William K. Thompson, Richard C. Kiefer, Gerard Tromp, Jie Xu, Eric B. Larson, Gail P. Jarvik, Abel N. Kho, Jyotishman Pathak, Frank D. Mentch
Publikováno v:
Journal of the American Medical Informatics Association : JAMIA
Background Electronic health records (EHRs) are increasingly used for clinical and translational research through the creation of phenotype algorithms. Currently, phenotype algorithms are most commonly represented as noncomputable descriptive documen