Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kenneth M. Andrejko"'
Autor:
Lisa Bellin, Patrick K. Kim, Kenneth M. Andrejko, Nichelle Raj, Emma E. Furth, Charlotte A Haaxma, Yoram Weiss, Clifford S. Deutschman
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 280:G968-G973
Sepsis is the leading cause of death in surgical intensive care units. Although both mild sepsis secondary to cecal ligation and single puncture (CLP) and fulminant, double puncture CLP (2CLP) may provoke hepatocyte death, we hypothesize that regener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a142c9bdd08ea5ff8e651385ecdf90b
https://doi.org/10.1152/ajpgi.2001.280.5.g968
https://doi.org/10.1152/ajpgi.2001.280.5.g968
Publikováno v:
Critical Care Medicine. 29:589-596
ObjectiveSepsis is the leading cause of death in critically ill surgical patients. Septic hepatic dysfunction, an important determinant of outcome, is poorly understood but includes inappropriate transcriptional down-regulation. This may be modulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b5a7567b087d73e358356bba82afbd4
https://doi.org/10.1097/00003246-200103000-00021
https://doi.org/10.1097/00003246-200103000-00021
Publikováno v:
Shock. 11:347-355
Inflammatory stimulation of hepatic acute phase protein expression is, in part, modulated by tumor necrosis factor-alpha (TNFalpha), interleukin-1beta (IL-beta), and IL-6. These cytokines also may mediate some aspects of the persistent inflammation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::468eda498d73f8ce3c5a1cfd81be6f56
https://doi.org/10.1097/00024382-199905000-00008
https://doi.org/10.1097/00024382-199905000-00008
Autor:
Clifford S. Deutschman, Lisa Bellin, Kenneth M. Andrejko, Rachel Harrison, Barbara Haber, Eric Elenko, Rebecca Taub
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 273:R1709-R1718
Sepsis in rats decreases the hepatic expression of the gluconeogenic enzyme glucose-6-phosphatase (G6Pase). The aim of this study was to investigate the relationship among G6Pase transcription, mRNA, enzymatic activity, and serum glucose levels at di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6342a9dffa536e8cdb3991fee71004
https://doi.org/10.1152/ajpregu.1997.273.5.r1709
https://doi.org/10.1152/ajpregu.1997.273.5.r1709
Publikováno v:
Shock. 7:164-169
Sepsis alters energy production and utilization by the liver. Changes in both metabolic pathways that produce substrate (gluconeogenesis or ketogenesis) for organism-wide consumption or provide an alternative source of fuel for the liver (beta-oxidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f733452a611a20f64264496e69cf564a
https://doi.org/10.1097/00024382-199703000-00002
https://doi.org/10.1097/00024382-199703000-00002
Publikováno v:
Critical Care Medicine. 24:1947-1952
ObjectivesTo test the hypothesis that after cecal ligation and puncture in the rat, there is increased expression of the tumor necrosis factor (TNF)/interleukin-1-dependent, acute-phase reactant alpha1-acid glycoprotein in the liver, and that this ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdd0b2cfd9b1ee1bfb2cdb87754f1a6b
https://doi.org/10.1097/00003246-199612000-00004
https://doi.org/10.1097/00003246-199612000-00004
Autor:
Kenneth M. Andrejko, Arnoley S. Abcejo, Clifford S. Deutschman, Nichelle R. Raj, E. Andrew Ochroch
Publikováno v:
Shock (Augusta, Ga.). 36(5)
Sepsis is a poorly understood syndrome. Therefore, we examined the mechanisms underlying failed regeneration in sham-operated (SO), mildly septic (cecal ligation and single puncture [CLP]), and severely septic (cecal ligation with two punctures [2CLP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436419ab219c8556d3318ee1f6b5d5b9
https://pubmed.ncbi.nlm.nih.gov/21937957
https://pubmed.ncbi.nlm.nih.gov/21937957
Autor:
Patrick K. Kim, Nichelle R. Raj, Clifford S. Deutschman, Kenneth M. Andrejko, Maurizio Cereda
Sepsis, a lethal inflammatory syndrome, is characterized by organ system dysfunction. In the liver, we have observed decreased expression of genes encoding proteins modulating key processes. These include organic anion and bile acid transport. We hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6d650ca0dcfaf0b9e0863a9d989ff0
https://europepmc.org/articles/PMC2667679/
https://europepmc.org/articles/PMC2667679/
Autor:
Clifford S. Deutschman, Kenneth M. Andrejko, Charlotte A Haaxma, Patrick K. Kim, Nichelle R. Raj
Publikováno v:
Shock (Augusta, Ga.). 19(1)
Previous studies have demonstrated sepsis-specific changes in the transcription of key hepatic genes. However, the role of hepatic transcription factors in sepsis-associated organ dysfunction has not been well established. We hypothesize that the bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8709cfa904a4d4e8acd9af0b42ea0d
https://pubmed.ncbi.nlm.nih.gov/12558143
https://pubmed.ncbi.nlm.nih.gov/12558143
Publikováno v:
Shock (Augusta, Ga.). 14(2)
Hepatic dysfunction in sepsis is characterized by hyperbilirubinemia and intrahepatic cholestasis. We hypothesize that sepsis causes decreased hepatic transcription of the bile acid transporter sodium taurocholate cotransporter (Ntcp) and the organic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3619a7bd315907358411c50c76c3d18d
https://pubmed.ncbi.nlm.nih.gov/10947163
https://pubmed.ncbi.nlm.nih.gov/10947163