Identification of a homology-independent linchpin domain controlling mouse and bank vole prion protein conversion.

Autor: Cassandra M Burke, Kenneth M K Mark, Daniel J Walsh, Geoffrey P Noble, Alexander D Steele, Abigail B Diack, Jean C Manson, Joel C Watts, Surachai Supattapone

Publikováno v: PLoS Pathogens, Vol 16, Iss 9, p e1008875 (2020)

Prions are unorthodox pathogens that cause fatal neurodegenerative diseases in humans and other mammals. Prion propagation occurs through the self-templating of the pathogenic conformer PrPSc, onto the cell-expressed conformer, PrPC. Here we study th

Externí odkaz: https://doaj.org/article/56f2eed8818d434daa5cbc4eb00e3299

Cofactor and glycosylation preferences for in vitro prion conversion are predominantly determined by strain conformation.

Autor: Cassandra M Burke, Daniel J Walsh, Kenneth M K Mark, Nathan R Deleault, Koren A Nishina, Umberto Agrimi, Michele A Di Bari, Surachai Supattapone

Publikováno v: PLoS Pathogens, Vol 16, Iss 4, p e1008495 (2020)

Prion diseases are caused by the misfolding of a host-encoded glycoprotein, PrPC, into a pathogenic conformer, PrPSc. Infectious prions can exist as different strains, composed of unique conformations of PrPSc that generate strain-specific biological

Externí odkaz: https://doaj.org/article/406d5eb819124d0c8c142131103deceb

Identification of a Homology-Independent Linchpin Domain Controlling Mouse and Bank Vole Prion Protein Conversion

Autor: Cassandra M. Burke, Abigail B. Diack, Alexander D. Steele, Jean Manson, Surachai Supattapone, Daniel J. Walsh, Joel C. Watts, Geoffrey P. Noble, Kenneth M. K. Mark

Publikováno v: Burke, C M, Mark, K M K, Walsh, D J, Noble, G P, Steele, A D, Diack, A, Manson, J, Watts, J C & Supattapone, S 2020, ' Identification of a Homology-Independent Linchpin Domain Controlling Mouse and Bank Vole Prion Protein Conversion ', PLoS Pathogens . https://doi.org/10.1371/journal.ppat.1008875
PLoS Pathogens, Vol 16, Iss 9, p e1008875 (2020)
PLoS Pathogens

Prions are unorthodox pathogens that cause fatal neurodegenerative diseases in humans and other mammals. Prion propagation occurs through the self-templating of the pathogenic conformer PrPSc, onto the cell-expressed conformer, PrPC. Here we study th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac70061a80920de52ee6430caffe230
https://hdl.handle.net/20.500.11820/9aec28ec-3889-447a-887f-a78d26e6edc5

The E2F4 prognostic signature predicts pathological response to neoadjuvant chemotherapy in breast cancer patients

Autor: Matthew Ung, Chao Cheng, Feng Qian, Frederick S. Varn, Kenneth M. K. Mark

Publikováno v: BMC Cancer, Vol 17, Iss 1, Pp 1-11 (2017)
BMC Cancer

Background Neoadjuvant chemotherapy is a key component of breast cancer treatment regimens and pathologic complete response to this therapy varies among patients. This is presumably due to differences in the molecular mechanisms that underlie each tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08642cb98d956558dab9802547642fc
http://link.springer.com/article/10.1186/s12885-017-3297-2

SEC24A identified as an essential mediator of thapsigargin-induced cell death in a genome-wide CRISPR/Cas9 screen

Autor: Michael D. Cole, Tamutenda Chidawanyika, Elizabeth Sergison, Surachai Supattapone, Kenneth M. K. Mark

Publikováno v: Cell Death Discovery
Cell Death Discovery, Vol 4, Iss 1, Pp 1-13 (2018)

Endoplasmic reticulum (ER) stress from accumulated misfolded proteins in the ER can activate the unfolded protein response (UPR). The UPR acts either to restore proteostasis or to activate cell death pathways if the stress cannot be resolved. The key

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e49f7214c24cda0b78e869027817ab
http://europepmc.org/articles/PMC6299087