Výsledky vyhledávání - "Kenneth Lyon"

Kniha

People, food, and resources / Sir Kenneth Blaxter. [elektronicky zdroj]

Autor: Blaxter, K. L. Sir (Kenneth Lyon), author

Externí odkaz: Kolekce e-knih KNAV

Multicolour single-molecule tracking of mRNA interactions with RNP granules

Autor: Tatsuya Morisaki, Roy Parker, Timothy J. Stasevich, Stephanie L. Moon, Kenneth Lyon, Anthony Khong

Publikováno v: Nature cell biology

Ribonucleoprotein (RNP) granules are non-membrane-bound organelles that have critical roles in the stress response1,2, maternal messenger RNA storage3, synaptic plasticity4, tumour progression5,6 and neurodegeneration7-9. However, the dynamics of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da87b6fccc877dc91e060df5ddb8c0ea
https://doi.org/10.1038/s41556-018-0263-4

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Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function

Autor: Deborah S. Wuttke, Leslie W. Glustrom, Kenneth Lyon, Victoria Lundblad, Margherita Paschini, Nicholas V. Parsonnet, Cynthia M. Reyes, Tasha B. Toro

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Proteins that bind nucleic acids are frequently categorized as being either specific or nonspecific, with interfaces to match that activity. In this study, we have found that a telomere-binding protein exhibits a degree of specificity fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4023741bf6babe10ce969e9f1aa24aab
http://europepmc.org/articles/PMC6187146

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Detection and quantification of single mRNA dynamics with the Riboglow fluorescent RNA tag

Autor: Amy E. Palmer, Kenneth Lyon, Robert T. Batey, Timothy J. Stasevich, Esther Braselmann

Labeling and tracking biomolecules with fluorescent probes on the single molecule level enables quantitative insights into their dynamics in living cells. We previously developed Riboglow, a platform to label RNAs in live mammalian cells, consisting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e950adc21e211685ef6eff1fd808713
https://doi.org/10.1101/701649

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Live-cell single RNA imaging reveals bursts of translational frameshifting

Autor: Tatsuya Morisaki, Brian Munsky, Kenneth Lyon, Timothy J. Stasevich, Luis U. Aguilera

Ribosomal frameshifting during the translation of RNA is implicated in both human disease and viral infection. While previous work has uncovered many mechanistic details about single RNA frameshifting kineticsin vitro, very little is known about how

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e40ba5853d547f5dde62bb8ae7e834

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Imaging of single mRNA translation repression reveals diverse interactions with mRNP granules

Autor: Kenneth Lyon, Anthony Khong, Timothy J. Stasevich, Tatsuya Morisaki, Stephanie L. Moon, Roy Parker

During cellular stress mRNAs exit translation and accumulate in stress granules and P-bodies, although the dynamics of these interactions remain unclear. We imaged in real-time single mRNAs, their translational output, and mRNA-granule interactions d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40512a1b3b7a240a0d65a5d8104576f
https://doi.org/10.1101/332692

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Imaging translational and post-translational gene regulatory dynamics in living cells with antibody-based probes

Autor: Kenneth Lyon, Timothy J. Stasevich

Antibody derivatives, such as antibody fragments (Fab) and single-chain variable fragments (scFv), are now being used to image traditionally hard-to-see protein subpopulations, including nascent polypeptides being translated and post-translationally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609783393df2fa07f78908027d81dc44
https://europepmc.org/articles/PMC5526335/

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Real-time quantification of single RNA translation dynamics in living cells

Autor: Tatsuya Morisaki, Sarada Viswanathan, Jonathan B. Grimm, Jennifer G. DeLuca, Brian P. English, Luke D. Lavis, Timothy J. Stasevich, Keith F. DeLuca, Loren L. Looger, Timothée Lionnet, Kenneth Lyon, Zhengjian Zhang

Publikováno v: Science (New York, N.Y.). 352(6292)

The when, where, and how of translation High-resolution single-molecule imaging shows the spatial and temporal dynamics of molecular events (see the Perspective by Iwasaki and Ingolia). Wu et al. and Morisaki et al. developed an approach to study the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20866c24a0782bd537ab28c7882d4aa9
https://pubmed.ncbi.nlm.nih.gov/27404883

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