Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kenneth Longo"'
Autor:
Yuanjing Liu, Jean-Cosme Dodart, Helene Tran, Shaunna Berkovitch, Maurine Braun, Michael Byrne, Ann F. Durbin, Xiao Shelley Hu, Naoki Iwamoto, Hyun Gyung Jang, Pachamuthu Kandasamy, Fangjun Liu, Kenneth Longo, Jörg Ruschel, Juili Shelke, Hailin Yang, Yuan Yin, Amy Donner, Zhong Zhong, Chandra Vargeese, Robert H. Brown
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
C9orf72 expansion mutations are the most common genetic cause of ALS and FTD, which have limited therapies. The authors generate stereopure oligonucleotides that selectively deplete expansion-containing transcripts and protect against expansion-assoc
Externí odkaz:
https://doaj.org/article/c67a2cf526554819ac5be15eaecb07de
Autor:
Kenneth Longo Mlelwa
The growth of mobile payments gave rise to several security threats to users. These threats are attributed to vulnerabilities due to ignorance, technical issues, inadequate regulations, information about mobile transactions, and lack of formal compla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122329dac72a4e1f9017af42fd04e0b7
Autor:
Kenneth Longo Mlelwa
The focus of this study was to examine if there is a relationship between ICT use and success in criminal investigations in Dar es Salaam Special Police Zone. Descriptive and inferential survey designs were adopted. Analysis was done using frequencie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255e7f8eb6eb670ee8283acc0a2b08a8
Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS
Autor:
Pachamuthu Kandasamy, Yuanjing Liu, Vincent Aduda, Sandheep Akare, Rowshon Alam, Amy Andreucci, David Boulay, Keith Bowman, Michael Byrne, Megan Cannon, Onanong Chivatakarn, Juili Dilip Shelke, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Sarah Lamore, Muriel Lemaitre, Xuena Lin, Kenneth Longo, Richard Looby, Subramanian Marappan, Jake Metterville, Susovan Mohapatra, Bridget Newman, Ik-Hyeon Paik, Saurabh Patil, Erin Purcell-Estabrook, Mamoru Shimizu, Pochi Shum, Stephany Standley, Kris Taborn, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Elena Dale, Chandra Vargeese
Publikováno v:
Nucleic Acids Research. 50:5401-5423
Attaining sufficient tissue exposure at the site of action to achieve the desired pharmacodynamic effect on a target is an important determinant for any drug discovery program, and this can be particularly challenging for oligonucleotides in deep tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bd2c8b0ca0bc373823740210c986ec
https://doi.org/10.1093/nar/gkac037
https://doi.org/10.1093/nar/gkac037
Autor:
ElenaAbbie DaleMaguire, Lankai Guo, Michael Byrne, Megan Cannon, Kris Taborn, Priyanka Shiva Prakasha, Kenneth Longo, Naoki Iwamoto, Pachamuthu Kandasamy, Mamoru Shimizu, Pochi Shum, Ashwini Ranade, Raghuvaran Iyer, Keith Bowman, Hailin Yang, Yuan Benny Yin, Fangjun Liu, Susovan Mohapatra, Lilia Macovei, Saurabh Patil, Janice Lansita, Xiao Shelley Hu, Karen Smith, Jaya Goyal, Padma Narayanan, Ken Rhodes, Michael Panzara, Chandra Vargeese
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56470a680ebd876284149c9abf9945ca
https://doi.org/10.1002/alz.063730
https://doi.org/10.1002/alz.063730
Autor:
Pachamuthu Kandasamy, Ann Fiegen Durbin, Michael Byrne, Robert H. Brown, Jean-Cosme Dodart, Yuan Yin, Kenneth Longo, Amy Donner, Fangjun Liu, Xiao Shelley Hu, Naoki Iwamoto, Juili Dilip Shelke, Maurine Braun, Chandra Vargeese, Jörg Ruschel, Hailin Yang, Helene Tran, Shaunna Berkovitch, Yuanjing Liu, Zhong Zhong, Hyun Gyung Jang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
A large G4C2-repeat expansion in C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Neuronal degeneration associated with this expansion arises from a loss of C9orf72 protein, the accumu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd5a4da0d93fe4e3773026ba3df968a1
https://doaj.org/article/c67a2cf526554819ac5be15eaecb07de
https://doaj.org/article/c67a2cf526554819ac5be15eaecb07de
Autor:
Daniel Dorset, Ramakrishna Boyanapalli, Kenneth Longo, Jeffrey M. Brown, Aaron J. Morris, Nripesh Prasad, Scott Yourstone, Shawn Levy, Chandra Vargeese, Nenad Svrzikapa, Jaya Goyal, Jason Powers
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 162-173 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 162-173 (2020)
Novel treatments for Huntington’s disease (HD), a progressive neurodegenerative disorder, include selective targeting of the mutant allele of the huntingtin gene (mHTT) carrying the abnormally expanded disease-causing cytosine-adenine-guanine (CAG)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a876e8e2835d79e2bba28b9a1adca6
http://europepmc.org/articles/PMC7648085
http://europepmc.org/articles/PMC7648085
Publikováno v:
Nucleic acids research. 50(6)
Alternative splicing is frequently involved in the diversification of protein function and can also be modulated for therapeutic purposes. Here we develop a predictive model, called Exon ByPASS (predicting Exon skipping Based on Protein amino acid Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655724867f2fbdd34b0655cc3b75408d
https://pubmed.ncbi.nlm.nih.gov/35286381
https://pubmed.ncbi.nlm.nih.gov/35286381
Autor:
Pachamuthu Kandasamy, Graham McClorey, Mamoru Shimizu, Nayantara Kothari, Rowshon Alam, Naoki Iwamoto, Jayakanthan Kumarasamy, Gopal R Bommineni, Adam Bezigian, Onanong Chivatakarn, David C D Butler, Michael Byrne, Katarzyna Chwalenia, Kay E Davies, Jigar Desai, Juili Dilip Shelke, Ann F Durbin, Ruth Ellerington, Ben Edwards, Jack Godfrey, Andrew Hoss, Fangjun Liu, Kenneth Longo, Genliang Lu, Subramanian Marappan, Jacopo Oieni, Ik-Hyeon Paik, Erin Purcell Estabrook, Chikdu Shivalila, Maeve Tischbein, Tomomi Kawamoto, Carlo Rinaldi, Joana Rajão-Saraiva, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Cong Zhou, Jason Zhang, Luciano Apponi, Matthew J A Wood, Chandra Vargeese
Publikováno v:
Nucleic acids research. 50(10)
Although recent regulatory approval of splice-switching oligonucleotides (SSOs) for the treatment of neuromuscular disease such as Duchenne muscular dystrophy has been an advance for the splice-switching field, current SSO chemistries have shown limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4563bb9a20823ec7e04b7dd2e362f73
https://pubmed.ncbi.nlm.nih.gov/35061895
https://pubmed.ncbi.nlm.nih.gov/35061895
Autor:
Michael, Byrne, Vinod, Vathipadiekal, Luciano, Apponi, Naoki, Iwamoto, Pachamuthu, Kandasamy, Kenneth, Longo, Fangjun, Liu, Richard, Looby, Lauren, Norwood, Anee, Shah, Juili Dilip, Shelke, Chikdu, Shivalila, Hailin, Yang, Yuan, Yin, Lankai, Guo, Keith, Bowman, Chandra, Vargeese
Publikováno v:
Translational Vision Science & Technology
Purpose Antisense oligonucleotides have been under investigation as potential therapeutics for many diseases, including inherited retinal diseases. Chemical modifications, such as chiral phosphorothioate (PS) backbone modification, are often used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::575c2acf4b12d20dd0ba7bd1766360f8
https://pubmed.ncbi.nlm.nih.gov/33510962
https://pubmed.ncbi.nlm.nih.gov/33510962