Every Interaction of Every Moment of Every Day: Establishing Positive Middle School Teacher-Student Connections.

Autor: Reimer, Kenneth Lloyd¹

Publikováno v: Journal of Academic Perspectives. 2024, Issue 2, p167-176. 10p.

Plinabulin, a Distinct Microtubule-Targeting Chemotherapy, Promotes M1-Like Macrophage Polarization and Anti-tumor Immunity

Autor: Marina Natoli, Petra Herzig, Elham Pishali Bejestani, Melanie Buchi, Reto Ritschard, G. Kenneth Lloyd, Ramon Mohanlal, James R. Tonra, Lan Huang, Viola Heinzelmann, Marta Trüb, Alfred Zippelius, Abhishek S. Kashyap

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Reprogramming tumor infiltrating myeloid cells to elicit pro-inflammatory responses is an exciting therapeutic maneouver to improve anti-tumor responses. We recently demonstrated that a distinct microtubule-targeting drug, plinabulin—a clinical-sta

Externí odkaz: https://doaj.org/article/d21b4ca37c104d1593f619178ef9f5c2

Plinabulin ameliorates neutropenia induced by multiple chemotherapies through a mechanism distinct from G-CSF therapies

Autor: Ramon Mohanlal, James R. Tonra, Lan Huang, G. Kenneth Lloyd

Publikováno v: Cancer Chemotherapy and Pharmacology

Purpose Chemotherapy-induced neutropenia (CIN) increases the risk of infections and mortality in cancer patients. G-CSF therapies are approved for the treatment of CIN, but non-G-CSF therapies are needed to increase efficacy and minimize side effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbfe03aa14e4852c541639a6a0bb4fe
https://doi.org/10.1007/s00280-019-03998-w

Intrauterine growth restriction decreases NF-κB signaling in fetal pulmonary artery endothelial cells of fetal sheep

Autor: Paul J. Rozance, Timothy M. Crombleholme, Jason Gien, Cristina M. Alvira, Kenneth Lloyd Jones, Steven H. Abman, Gregory J. Seedorf, Kyle N Powers, David P. Astling, R. Blair Dodson

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 315:L348-L359

Intrauterine growth restriction (IUGR) in premature newborns increases the risk for bronchopulmonary dysplasia, a chronic lung disease characterized by disrupted pulmonary angiogenesis and alveolarization. We previously showed that experimental IUGR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf0c320c435a4216b27cb336398d8e4
https://doi.org/10.1152/ajplung.00052.2018

Structure, Thermodynamics, and Kinetics of Plinabulin Binding to Two Tubulin Isotypes

Autor: Michel O. Steinmetz, G. Kenneth Lloyd, Francisco de Asis Balaguer Perez, Lan Huang, Giuseppina La Sala, Andrea Cavalli, Natacha Olieric, Federica Viti, José Fernando Díaz, Ashwani Sharma, Sergio Decherchi, James R. Tonra

Publikováno v: Chem (Cambridge. Print) 5 (2019): 2969–2986. doi:10.1016/j.chempr.2019.08.022
info:cnr-pdr/source/autori:La Sala G.; Olieric N.; Sharma A.; Viti F.; de Asis Balaguer Perez F.; Huang L.; Tonra J.R.; Lloyd G.K.; Decherchi S.; Diaz J.F.; Steinmetz M.O.; Cavalli A./titolo:Structure, Thermodynamics, and Kinetics of Plinabulin Binding to Two Tubulin Isotypes/doi:10.1016%2Fj.chempr.2019.08.022/rivista:Chem (Cambridge. Print)/anno:2019/pagina_da:2969/pagina_a:2986/intervallo_pagine:2969–2986/volume:5
Digital.CSIC. Repositorio Institucional del CSIC
instname

25 p.-5 fig.-1 tab. + 6 fig. supl.+ 1 tab. supl.
αβ-Tubulin is a validated target for anticancer drug discovery, and molecules binding to this protein are used to treat several types of tumors. Here, we report on a combined X-ray crystallograp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b99b1daca5dd2565c568532d8c33feb
http://www.cnr.it/prodotto/i/449379