Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Kenneth L. Wright"'
Autor:
ThuLe Trinh, William A. Adams, Alexandra Calescibetta, Nhan Tu, Robert Dalton, Tina So, Max Wei, Grace Ward, Elena Kostenko, Sean Christiansen, Ling Cen, Amy McLemore, Kayla Reed, Junmin Whitting, Danielle Gilvary, Neale Lopez Blanco, Carlos Moran Segura, Jonathan Nguyen, Wendy Kandell, Xianghong Chen, Pingyan Cheng, Gabriela M. Wright, W. Douglas Cress, Jinghong Liu, Kenneth L. Wright, Sheng Wei, Erika A. Eksioglu
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106443- (2023)
Summary: Advances in the understanding of the tumor microenvironment have led to development of immunotherapeutic strategies, such as chimeric antigen receptor T cells (CAR-Ts). However, despite success in blood malignancies, CAR-T therapies in solid
Externí odkaz:
https://doaj.org/article/09130f12d9894f7784d26defbf9b2e06
Autor:
Grace A. Ward, Robert P. Dalton, Benjamin S. Meyer, Amy F. McLemore, Amy L. Aldrich, Nghi B. Lam, Alexis H. Onimus, Nicole D. Vincelette, Thu Le Trinh, Xianghong Chen, Alexandra R. Calescibetta, Sean M. Christiansen, Hsin-An Hou, Joseph O. Johnson, Kenneth L. Wright, Eric Padron, Erika A. Eksioglu, Alan F. List
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3896 (2023)
Myelodysplastic Syndromes (MDSs) are bone marrow (BM) failure malignancies characterized by constitutive innate immune activation, including NLRP3 inflammasome driven pyroptotic cell death. We recently reported that the danger-associated molecular pa
Externí odkaz:
https://doaj.org/article/535eabfff964452e91030cfe28e8e79c
Autor:
AGM Mostofa, Allison Distler, Mark B. Meads, Eva Sahakian, John J. Powers, Alexandra Achille, David Noyes, Gabriela Wright, Bin Fang, Victoria Izumi, John Koomen, Rupal Rampakrishnan, Tuan P. Nguyen, Gabriel De Avila, Ariosto S. Silva, Praneeth Sudalagunta, Rafael Renatino Canevarolo, Maria D. Coelho Siqueira Silva, Raghunandan Reddy Alugubelli, Hongyue A. Dai, Amit Kulkarni, William S. Dalton, Oliver A. Hampton, Eric A. Welsh, Jamie K. Teer, Alexandre Tungesvik, Kenneth L. Wright, Javier Pinilla-Ibarz, Eduardo M. Sotomayor, Kenneth H. Shain, Jason Brayer
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
The clinical utility of histone/protein deacetylase (HDAC) inhibitors in combinatorial regimens with proteasome inhibitors for patients with relapsed and refractory multiple myeloma (MM) is often limited by excessive toxicity due to HDAC inhibitor pr
Externí odkaz:
https://doaj.org/article/7fe4645c54d74f3db9e69957840e8738
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are associated with clonal myelopoiesis, elevated risk of death due to thrombotic complications, and transformation to acute myeloid leukemia (AML). JAK2 inhibitors improve the qual
Externí odkaz:
https://doaj.org/article/28fd1cc32c33490eb394cfbaa31efe0f
Autor:
Lou-Ella M.M. Alexander, January Watters, Jessica A. Reusch, Michelle Maurin, Brook S. Nepon-Sixt, Katerina Vrzalikova, Mark G. Alexandrow, Paul G. Murray, Kenneth L. Wright
Publikováno v:
Data in Brief, Vol 15, Iss , Pp 222-227 (2017)
The data presented here are related to the research article entitled âSelective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survivalâ (Alexander et al., 2017) [1]. The cited research arti
Externí odkaz:
https://doaj.org/article/318227ac38ac4a278d599af9df98bd2d
Autor:
Robert Dalton, Alexandra Calescibetta, Jun Min Zhou, Michelle Maurin, Grace Ward, Thu Le Trinh, Nhan Tu, Danielle Gilvary, Xianghong Chen, Pingyan Cheng, Elena Kostenko, Sheng Wei, Kenneth L. Wright, Erika A. Eksioglu
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1241 (2021)
Dendritic cells (DCs) are professional antigen presenting cells with a great capacity for cross-presentation of exogenous antigens from which robust anti-tumor immune responses ensue. However, this function is not always available and requires DCs to
Externí odkaz:
https://doaj.org/article/55956b22ad4443f2bf311ec3923596e6
Autor:
Katerina Vrzalikova, Sarah Leonard, Yichao Fan, Andrew Bell, Martina Vockerodt, Patrik Flodr, Kenneth L. Wright, Martin Rowe, Qian Tao, Paul G. Murray
Publikováno v:
Pathogens, Vol 1, Iss 2, Pp 83-101 (2012)
B-lymphocyte-induced maturation protein 1 (BLIMP1) exists as two major isoforms, α and β, which arise from alternate promoters. Inactivation of the full length BLIMP1α isoform is thought to contribute to B cell lymphomagenesis by blocking post-ger
Externí odkaz:
https://doaj.org/article/05d3754645e247a9b069b3ebd3938abc
Autor:
Kenneth L. Wright, Eduardo Sotomayor, Jianguo Tao, Sophie Dessureault, Sophia C.E. Bolick, Matthew A. Smith, Michelle Maurin, Shruti Desai
Supplementary Figures S1-S2 and Supplementary Tables S1-S3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20107a066a3655817da30c6d10052d49
https://doi.org/10.1158/1541-7786.22519476
https://doi.org/10.1158/1541-7786.22519476
Autor:
Erika A. Eksioglu, Gabriela M. Wright, Jason M. Foulks, Matthew Lalonde, Steven L. Warner, Kenneth L. Wright
Publikováno v:
Cancer Research. 83:5150-5150
Background: The inflammaging modulator, S100A9, mediates immunosuppression and plays a key role in the pathogenesis of low-risk myelodysplastic syndrome (MDS). Specifically, S100A9’s feedforward activation in the bone marrow (BM) induces pyroptotic
Autor:
John Powers, Tuan P Nguyen, Mark B. Meads, Jason Brayer, David Noyes, Eduardo M. Sotomayor, William S. Dalton, Kenneth L. Wright, Maria D Coelho Siqueira Silva, Allison Distler, Gabriel De Avila, Hongyue A Dai, Eva Sahakian, Oliver A. Hampton, Kenneth H. Shain, Alexandre Tungesvik, John M. Koomen, Praneeth Reddy Sudalagunta, Amit Kulkarni, Raghunandan Reddy Alugubelli, A.G.M. Mostofa, Victoria Izumi, Bin Fang, Ariosto S. Silva, Javier Pinilla-Ibarz, Jamie K. Teer, Eric A. Welsh, Alexandra Achille, Gabriela Wright, Rupal Rampakrishnan, Rafael Renatino Canevarolo
Publikováno v:
JCI Insight
The clinical utility of histone/protein deacetylase (HDAC) inhibitors in combinatorial regimens with proteasome inhibitors for patients with relapsed and refractory multiple myeloma (MM) is often limited by excessive toxicity due to HDAC inhibitor pr